Partial change in EphA4 knockout mouse phenotype: Loss of diminished GFAP upregulation following spinal cord injury

Neuroscience Letters

Volumn 525, Issue 1, 2012, Pages 66-71

  Dixon, Kirsty J ^a,b,d   Munro, Kathryn M ^a   Boyd, Andrew W ^c   Bartlett, Perry F ^b   Turnley, Ann M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

129SvJ; Astrocyte reactivity; C57Bl 6; EphA4; GFAP; Proliferation

Indexed keywords

EPHRIN A4; EPHRIN RECEPTOR A4; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; ATTENUATION; CELL COUNT; CELL PROLIFERATION; CELL STRUCTURE; FEMALE; MALE; MOUSE; NERVE REGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ASTROCYTES; BREEDING; CELL PROLIFERATION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RECEPTOR, EPHA4; SPECIES SPECIFICITY; SPINAL CORD INJURIES; UP-REGULATION;

EID: 84865333333     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.07.023     Document Type: Article

References (22)

1. Cruz-Orengo L., Figueroa J.D., Torrado A., Puig A., Whittemore S.R., Miranda J.D. Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response. Neuroscience Letters 2007, 418:49-54.
2. Cruz-Orengo L., Figueroa J.D., Velazquez I., Torrado A., Ortiz C., Hernandez C., Puig A., Segarra A.C., Whittemore S.R., Miranda J.D. Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Experimental Neurology 2006, 202:421-433.
3. de Mooij-van Malsen J.G., Yu K.L., Veldman H., Oppelaar H., van den Berg L.H., Olivier B., Kas M.J. Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice. Neuroscience 2009, 164:1477-1483.
4. Dottori M., Hartley L., Galea M., Paxinos G., Polizzotto M., Kilpatrick T., Bartlett P.F., Murphy M., Kontgen F., Boyd A.W. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:13248-13253.
5. Fabes J., Anderson P., Brennan C., Bolsover S. Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. European Journal of Neuroscience 2007, 26:2496-2505.
6. Fabes J., Anderson P., Yanez-Munoz R.J., Thrasher A., Brennan C., Bolsover S. Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion. European Journal of Neuroscience 2006, 23:1721-1730.
7. Goldshmit Y., Bourne J. Upregulation of EphA4 on astrocytes potentially mediates astrocytic gliosis after cortical lesion in the marmoset monkey. Journal of Neurotrauma 2010, 27:1321-1332.
8. Goldshmit Y., Galea M.P., Wise G., Bartlett P.F., Turnley A.M. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. Journal of Neuroscience 2004, 24:10064-10073.
9. Goldshmit Y., McLenachan S., Turnley A. Roles of Eph receptors and ephrins in the normal and damaged adult CNS. Brain Research Reviews 2006, 52:327-345.
10. Goldshmit Y., Spanevello M.D., Tajouri S., Li L., Rogers F., Pearse M., Galea M., Bartlett P.F., Boyd A.W., Turnley A.M. EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice. PLoS One 2011, 6.
11. Herrmann J.E., Shah R.R., Chan A.F., Zheng B. EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury. Experimental Neurology 2010, 223:582-598.
12. Kullander K., Butt S.J., Lebret J.M., Lundfald L., Restrepo C.E., Rydstrom A., Klein R., Kiehn O. Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science 2003, 299:1889-1892.
13. Leighton P.A., Mitchell K.J., Goodrich L.V., Lu X., Pinson K., Scherz P., Skarnes W.C., Tessier-Lavigne M. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature 2001, 410:174-179.
14. Ma M., Wei P., Wei T., Ransohoff R.M., Jakeman L.B. Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response. Journal of Comparative Neurology 2004, 474:469-486.
15. Munoz J.J., Alfaro D., Garcia-Ceca J., Alonso C.L., Jimenez E., Zapata A. Thymic alterations in EphA4-deficient mice. Journal of Immunology 2006, 177:804-813.
16. Munro K.M., Perreau V.M., Turnley A.M. Differential gene expression in the EphA4 knockout spinal cord and analysis of the inflammatory response following spinal cord injury. PLoS One 2012, 7:e37635. 10.1371/journal.pone.0037635.
17. North H.A., Zhao X., Kolk S.M., Clifford M.A., Ziskind D.M., Donoghue M.J. Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development 2009, 136:2467-2476.
18. Parmentier-Batteur S., Finger E.N., Krishnan R., Rajapakse H.A., Sanders J.M., Kandpal G., Zhu H., Moore K.P., Regan C.P., Sharma S., Hess J.F., Williams T.M., Reynolds I.J., Vacca J.P., Mark R.J., Nantermet P.G. Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors. Journal of Neurochemistry 2011, 118:1016-1031.
19. Puschmann T.B., Turnley A.M. Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. Journal of Neurochemistry 2010, 113:881-894.
20. Sawada T., Jing X., Zhang Y., Shimada E., Yokote H., Miyajima M., Sakaguchi K. Ternary complex formation of EphA4, FGFR and FRS2alpha plays an important role in the proliferation of embryonic neural stem/progenitor cells. Genes to Cells 2010.
21. White R.E., Jakeman L.B. Don't fence me in: harnessing the beneficial roles of astrocytes for spinal cord repair. Restorative Neurology and Neuroscience 2008, 26:197-214.
22. Wilhelmsson U., Li L., Pekna M., Berthold C.H., Blom S., Eliasson C., Renner O., Bushong E., Ellisman M., Morgan T.E., Pekny M. Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. Journal of Neuroscience 2004, 24:5016-5021.