Levels of circulating endothelial cells and colony-forming units are influenced by age and dyslipidemia

Pediatric Research

Volumn 72, Issue 3, 2012, Pages 299-304

  Fabbri Arrigoni, Francesca I ^a,b   Clarke, Lindsey ^a   Wang, Guosu ^a   Charakida, Marietta ^a   Ellins, Elizabeth ^a,c   Halliday, Neil ^a   Brogan, Paul A ^a   Deanfield, John E ^a   Halcox, Julian P ^a,c   Klein, Nigel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KINGSTON UNIVERSITY   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CHILD; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOMETRY; DYSLIPIDEMIA; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; AGE FACTORS; AGED; CASE-CONTROL STUDIES; CHILD; DYSLIPIDEMIAS; ENDOTHELIAL CELLS; HUMANS; MIDDLE AGED; STEM CELLS; YOUNG ADULT;

EID: 84865331045     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.76     Document Type: Article

References (40)

1. Grundy SM. Age as a risk factor: you are as old as your arteries. Am J Cardiol 1999;83:1455-7, A7. (Pubitemid 29228343)
2. Dawber TR. The Framingham Study: The Epidemiology of Atherosclerotic Disease. Cambridge, MA: Harvard University Press, 1980.
3. Clarke LA, Shah V, Arrigoni F, et al. Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction. J Thromb Haemost 2008;6: 1025-32. (Pubitemid 351689926)
4. Deanfield J, Donald A, Ferri C, et al. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005;23:7-17. (Pubitemid 40128972)
5. Jarvisalo MJ, Jartti L, Nanto-Salonen K, et al. Increased aortic intima- media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 2001;104:2943-7. (Pubitemid 33139107)
6. Murray C, Lopez A. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva, Switzerland: World Health Organization, 2002:230.
7. Virkola K, Pesonen E, Akerblom HK, Siimes MA. Cholesterol and carotid artery wall in children and adolescents with familial hypercholesterolaemia: a controlled study by ultrasound. Acta Paediatr 1997;86:1203-7. (Pubitemid 27509433)
8. Yoder MC, Mead LE, Prater D, et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007;109:1801-9. (Pubitemid 46348173)
9. Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600. (Pubitemid 36204953)
10. Werner N, Kosiol S, Schiegl T, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353:999-1007. (Pubitemid 41262334)
11. Schmidt-Lucke C, Rossig L, Fichtlscherer S, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005;111:2981-7. (Pubitemid 40814192)
12. Vasa M, Fichtlscherer S, Adler K, et al. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 2001;103:2885-90. (Pubitemid 32578123)
13. Imanishi T, Hano T, Matsuo Y, Nishio I. Oxidized low-density lipoprotein inhibits vascular endothelial growth factor-induced endothelial progenitor cell differentiation. Clin Exp Pharmacol Physiol 2003;30:665-70. (Pubitemid 37222744)
14. Imanishi T, Hano T, Sawamura T, Nishio I. Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol 2004;31:407-13. (Pubitemid 39044118)
15. Croce G, Passacquale G, Necozione S, Ferri C, Desideri G. Nonpharmacological treatment of hypercholesterolemia increases circulating endothelial progenitor cell population in adults. Arterioscler Thromb Vasc Biol 2006;26:e38-9. (Pubitemid 43732094)
16. Hoetzer GL, MacEneaney OJ, Irmiger HM, et al. Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults. Am J Cardiol 2007;99: 46-8. (Pubitemid 44969339)
17. Jie KE, Goossens MH, van Oostrom O, Lilien MR, Verhaar MC. Circulating endothelial progenitor cell levels are higher during childhood than in adult life. Atherosclerosis 2009;202:345-7.
18. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7. (Pubitemid 27087709)
19. Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008;28:1584-95.
20. Minami E, Laflamme MA, Saffitz JE, Murry CE. Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation 2005;8:19.
21. Hagensen MK, Shim J, Thim T, Falk E, Bentzon JF. Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation 2010;121:898-905.
22. Gulati R, Jevremovic D, Witt TA, et al. Modulation of the vascular response to injury by autologous blood-derived outgrowth endothelial cells. Am J Physiol Heart Circ Physiol 2004;287:H512-7. (Pubitemid 38955278)
23. Gehling UM, Ergun S, Fiedler W. CFU-EC: how they were originally defined. Blood 2007;110:1073. (Pubitemid 47267450)
24. Werner N, Wassmann S, Ahlers P, et al. Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease. Basic Res Cardiol 2007;102:565-71. (Pubitemid 47578401)
25. Fadini GP, Coracina A, Baesso I, et al. Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population. Stroke 2006;37:2277-82. (Pubitemid 44337169)
26. Westerweel PE, Visseren FL, Hajer GR, et al. Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. Eur Heart J 2008;29:2808-17.
27. Tepper OM, Galiano RD, Capla JM, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002;106:2781-6. (Pubitemid 35396976)
28. Fadini GP, de Kreutzenberg S, Agostini C, et al. Low CD34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes. Atherosclerosis 2009;207:213-9.
29. Woywodt A, Blann AD, Kirsch T, et al. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 2006;4:671-7.
30. Bulut D, Tuns H, Mugge A. CD31+/Annexin V+ microparticles in healthy offsprings of patients with coronary artery disease. Eur J Clin Invest 2009;39:17-22.
31. Smadja DM, Gaussem P, Mauge L, et al. Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease. Circulation 2009;119:374-81.
32. Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet 2004;363:369-70. (Pubitemid 38169546)
33. Smilde TJ, van Wissen S, Wollersheim H, Kastelein JJ, Stalenhoef AF. Genetic and metabolic factors predicting risk of cardiovascular disease in familial hypercholesterolemia. Neth J Med 2001;59:184-95. (Pubitemid 32913050)
34. Sorensen KE, Celermajer DS, Georgakopoulos D, Hatcher G, Betteridge DJ, Deanfield JE. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest 1994;93:50-5. (Pubitemid 24030819)
35. Walther C, Adams V, Bothur I, et al. Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells. Eur J Cardiovasc Prev Rehabil 2008;15:416-22.
36. Reilly JJ, Methven E, McDowell ZC, et al. Health consequences of obesity. Arch Dis Child 2003;88:748-52. (Pubitemid 37094225)
37. Charakida M, Donald AE, Green H, et al. Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005;112:103-9. (Pubitemid 40962575)
38. Kari JA, Donald AE, Vallance DT, et al. Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 1997;52:468-72. (Pubitemid 27359590)
39. Arrigoni FI, Matarin M, Thompson PJ, et al. Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. Eur J Hum Genet 2011;19:131-7.
40. Donald AE, Halcox JP, Charakida M, et al. Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation. J Am Coll Cardiol 2008;51:1959-64. (Pubitemid 351636449)