Maternal antibodies to infectious agents and risk for non-affective psychoses in the offspring-a matched case-control study

Schizophrenia Research

Volumn 140, Issue 1-3, 2012, Pages 25-30

  Blomström, Åsa ^a   Karlsson, Håkan ^a   Wicks, Susanne ^a   Yang, Shuojia ^b   Yolken, Robert H ^b   Dalman, Christina ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytomegalovirus; Fetal; Herpes simplex virus; Psychosis; Schizophrenia; Toxoplasma gondii

Indexed keywords

IMMUNOGLOBULIN E; MATERNAL ANTIBODY;

ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DISEASE ASSOCIATION; DRIED BLOOD SPOT TESTING; FEMALE; GESTATION PERIOD; GESTATIONAL AGE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; MOTHER FETUS RELATIONSHIP; NONAFFECTIVE PSYCHOSIS; NONHUMAN; PRENATAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; PROGENY; PSYCHOSIS; RISK FACTOR; SCHIZOPHRENIA; SWEDEN; TOXOPLASMA GONDII;

ADULT; CASE-CONTROL STUDIES; CYTOMEGALOVIRUS; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MATERNAL EXPOSURE; ODDS RATIO; PREGNANCY; PSYCHOTIC DISORDERS; RISK FACTORS; SCHIZOPHRENIA; SIMPLEXVIRUS; SWEDEN; TOXOPLASMA;

EID: 84865318698     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.06.035     Document Type: Article

References (38)

1. Ahlfors K., Ivarsson S.A., Johnsson T., Svanberg L. Primary and secondary maternal cytomegalovirus infections and their relation to congenital infection. Analysis of maternal sera. Acta Paediatr. Scand. 1982, 71(1):109-113.
2. Ahlfors K., Ivarsson S.A., Harris S. Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature. Scand. J. Infect. Dis. 1999, 31(5):443-457.
3. Brown A.S., Hooton J., Schaefer C.A., Zhang H., Petkova E., Babulas V., Perrin M., Gorman J.M., Susser E.S. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am. J. Psychiatry 2004, 161(5):889-895.
4. Brown A.S., Schaefer C.A., Quesenberry C.P., Liu L., Babulas V.P., Susser E.S. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am. J. Psychiatry 2005, 162(4):767-773.
5. Brown A.S., Schaefer C.A., Quesenberry C.P., Shen L., Susser E.S. No evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia?. Am. J. Psychiatry 2006, 163(12):2178-2180.
6. Buka S.L., Tsuang M.T., Torrey E.F., Klebanoff M.A., Bernstein D., Yolken R.H. Maternal infections and subsequent psychosis among offspring. Arch. Gen. Psychiatry 2001, 58(11):1032-1037.
7. Buka S.L., Tsuang M.T., Torrey E.F., Klebanoff M.A., Wagner R.L., Yolken R.H. Maternal cytokine levels during pregnancy and adult psychosis. Brain Behav. Immun. 2001, 15(4):411-420.
8. Buka S.L., Cannon T.D., Torrey E.F., Yolken R.H. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. Biol. Psychiatry 2008, 63(8):809-815.
9. Byrne M., Agerbo E., Ewald H., Eaton W.W., Mortensen P.B. Parental age and risk of schizophrenia: a case-control study. Arch. Gen. Psychiatry 2003, 60(7):673-678.
10. Cantor-Graae E., Selten J.P. Schizophrenia and migration: a meta-analysis and review. Am. J. Psychiatry 2005, 162(1):12-24.
11. Cochran T.E. Fetal and maternal immunoglobulin concentrations at delivery and post partum. J. Obstet. Gynaecol. Br. Commonw. 1972, 79(3):238-243.
12. Condorelli F., Scalia G., Stivala A., Gallo R., Marino A., Battaglini C.M., Castro A. Detection of immunoglobulin G to measles virus, rubella virus, and mumps virus in serum samples and in microquantities of whole blood dried on filter paper. J. Virol. Methods 1994, 49(1):25-36.
13. Dalman C., Allebeck P., Gunnell D., Harrison G., Kristensson K., Lewis G., Lofving S., Rasmussen F., Wicks S., Karlsson H. Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects. Am. J. Psychiatry 2008, 165(1):59-65.
14. Forsgren M., Gille E., Ljungstrom I., Nokes D.J. Toxoplasma gondii antibodies in pregnant women in Stockholm in 1969, 1979, and 1987. Lancet 1991, 337(8754):1413-1414.
15. Forsgren M., Skoog E., Jeansson S., Olofsson S., Giesecke J. Prevalence of antibodies to herpes simplex virus in pregnant women in Stockholm in 1969, 1983 and 1989: implications for STD epidemiology. Int. J. STD AIDS 1994, 5(2):113-116.
16. Hoffmann C., Grossman R., Bokov I., Lipitz S., Biegon A. Effect of cytomegalovirus infection on temporal lobe development in utero: quantitative MRI studies. Eur. Neuropsychopharmacol. 2010, 20(12):848-854.
17. Jorgensen L., Ahlbom A., Allebeck P., Dalman C. The Stockholm non-affective psychoses study (snaps): the importance of including out-patient data in incidence studies. Acta Psychiatr. Scand. 2010, 121(5):389-392.
18. Kim J.J., Shirts B.H., Dayal M., Bacanu S.A., Wood J., Xie W., Zhang X., Chowdari K.V., Yolken R., Devlin B., Nimgaonkar V.L. Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?. Ann. Med. 2007, 39(2):145-153.
19. Kumar A., Jauhari P., Singh U., Singla P.N. Influence of gestational age on cord blood immunoglobulin and complement levels. Indian Pediatr. 1996, 33(1):44-46.
20. Lebech M., Petersen E. Detection by enzyme immunosorbent assay of Toxoplasma gondii IgG antibodies in dried blood spots on PKU-filter paper from newborns. Scand. J. Infect. Dis. 1995, 27(3):259-263.
21. Leweke F.M., Gerth C.W., Koethe D., Klosterkotter J., Ruslanova I., Krivogorsky B., Torrey E.F., Yolken R.H. Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2004, 254(1):4-8.
22. Malek A., Sager R., Schneider H. Maternal-fetal transport of immunoglobulin G and its subclasses during the third trimester of human pregnancy. Am. J. Reprod. Immunol. 1994, 32(1):8-14.
23. Meyer U. Developmental neuroinflammation and schizophrenia 2011, Prog Neuropsychopharmacol Biol Psychiatry.
24. Mortensen P.B., Norgaard-Pedersen B., Waltoft B.L., Sorensen T.L., Hougaard D., Torrey E.F., Yolken R.H. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol. Psychiatry 2007, 61(5):688-693.
25. Mortensen P.B., Pedersen C.B., Hougaard D.M., Norgaard-Petersen B., Mors O., Borglum A.D., Yolken R.H. A Danish National Birth Cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring. Schizophr. Res. 2010, 122(1-3):257-263.
26. Nahmias A.J., Lee F.K., Beckman-Nahmias S. Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world. Scand. J. Infect. Dis. Suppl. 1990, 69:19-36.
27. Norberg P., Kasubi M.J., Haarr L., Bergstrom T., Liljeqvist J.A. Divergence and recombination of clinical herpes simplex virus type 2 isolates. J. Virol. 2007, 81(23):13158-13167.
28. Peyron F., Lobry J.R., Musset K., Ferrandiz J., Gomez-Marin J.E., Petersen E., Meroni V., Rausher B., Mercier C., Picot S., Cesbron-Delauw M.F. Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect. 2006, 8(9-10):2333-2340.
29. Pope R.M. Immunoregulatory mechanisms present in the maternal circulation during pregnancy. Baillieres Clin. Rheumatol. 1990, 4(1):33-52.
30. Simister N.E. Placental transport of immunoglobulin G. Vaccine 2003, 21(24):3365-3369.
31. Stagno S. Cytomegalovirus. Infectious disease of the fetus and newborn infant 2001, WB Saunders, Philadelphia. 4th ed. J.S. Remington, J.O. Klein (Eds.).
32. Stefansson H., Ophoff R.A., Steinberg S., Andreassen O.A., Cichon S., Rujescu D., Werge T., Pietilainen O.P., Mors O., Mortensen P.B., Sigurdsson E., Gustafsson O., Nyegaard M., Tuulio-Henriksson A., Ingason A., Hansen T., Suvisaari J., Lonnqvist J., Paunio T., Borglum A.D., Hartmann A., Fink-Jensen A., Nordentoft M., Hougaard D., Norgaard-Pedersen B., Bottcher Y., Olesen J., Breuer R., Moller H.J., Giegling I., Rasmussen H.B., Timm S., Mattheisen M., Bitter I., Rethelyi J.M., Magnusdottir B.B., Sigmundsson T., Olason P., Masson G., Gulcher J.R., Haraldsson M., Fossdal R., Thorgeirsson T.E., Thorsteinsdottir U., Ruggeri M., Tosato S., Franke B., Strengman E., Kiemeney L.A., Melle I., Djurovic S., Abramova L., Kaleda V., Sanjuan J., de Frutos R., Bramon E., Vassos E., Fraser G., Ettinger U., Picchioni M., Walker N., Toulopoulou T., Need A.C., Ge D., Yoon J.L., Shianna K.V., Freimer N.B., Cantor R.M., Murray R., Kong A., Golimbet V., Carracedo A., Arango C., Costas J., Jonsson E.G., Terenius L., Agartz I., Petursson H., Nothen M.M., Rietschel M., Matthews P.M., Muglia P., Peltonen L., St Clair D., Goldstein D.B., Stefansson K., Collier D.A. Common variants conferring risk of schizophrenia. Nature 2009, 460(7256):744-747.
33. TheNationalBoardofHealthandWelfare The Medical Birth Register 2011, The National Board of Health and Welfare.
34. Torrey E.F., Yolken R.H. Could schizophrenia be a viral zoonosis transmitted from house cats?. Schizophr. Bull. 1995, 21(2):167-171.
35. Torrey E.F., Yolken R.H. Schizophrenia and toxoplasmosis. Schizophr. Bull. 2007, 33(3):727-728.
36. Torrey E.F., Leweke M.F., Schwarz M.J., Mueller N., Bachmann S., Schroeder J., Dickerson F., Yolken R.H. Cytomegalovirus and schizophrenia. CNS Drugs 2006, 20(11):879-885.
37. Xiao J., Buka S.L., Cannon T.D., Suzuki Y., Viscidi R.P., Torrey E.F., Yolken R.H. Serological pattern consistent with infection with type I Toxoplasma gondii in mothers and risk of psychosis among adult offspring. Microbes Infect. 2009, 11(13):1011-1018.
38. Yang S.L., Kleinman A.M., Rosenberg E.B., Wei P.Y. The effect of labor and mode of delivery on immunoglobulin concentrations in the neonate. Am. J. Obstet. Gynecol. 1971, 109(1):78-81.