Cognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter study

Parkinsonism and Related Disorders

Volumn 18, Issue 7, 2012, Pages 854-858

  Braga Neto, Pedro ^a   Felicio, Andre C ^a   Hoexter, Marcelo Q ^a   Pedroso, José Luiz ^a   Dutra, Lívia Almeida ^a   Alessi, Helena ^a   Minett, Thaís ^a,b   Santos Galduroz, Ruth F ^c   da Rocha, Antônio José ^d   Garcia, Lucas A L ^e   Bertolucci, Paulo Henrique F ^a   Bressan, Rodrigo A ^a   Barsottini, Orlando Graziani Povoas ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSIDADE FEDERAL DO ABC   (Brazil)

^d Section of Neuroradiology   (Brazil)

^e Clinica Medimagem   (Brazil)

Author keywords

Cognition; Cognitive deficits; Dopamine transporter; Machado Joseph disease; Olfaction; Spinocerebellar ataxia type 3

Indexed keywords

DOPAMINE TRANSPORTER; TECHNETIUM 99M;

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HUMAN; MACHADO JOSEPH DISEASE; MALE; MENTAL PERFORMANCE; NERVE DEGENERATION; NEUROIMAGING; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMELLING DISORDER; STROOP TEST;

ADULT; CEREBELLUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; MACHADO-JOSEPH DISEASE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; PUTAMEN; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84865315655     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2012.04.015     Document Type: Article

References (26)

1. Schöls L., Bauer P., Schmidt T., Schulte T., Riess O. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurol 2004, 3:291-304.
2. Braga-Neto P., Felicio A.C., Pedroso J.L., Dutra L.A., Bertolucci P.H., Gabbai A.A., et al. Clinical correlates of olfactory dysfunction in spinocerebellar ataxia type 3. Parkinsonism Relat Disord 2011, 17:353-356.
3. Radvany J., Camargo C.H.P., Costa Z.M., Fonseca N.C., Nascimento E.D. Machado Joseph disease of Azorean ancestry in Brazil: the Catarina kindred. Neurological, neuroimaging, psychiatric and neuropsychological findings in the largest known family, the Catarina kindred. Arq Neuropsiquiatr 1993, 51:21-30.
4. Klinke I., Minnerop M., Schmitz-Hübsch T., Hendriks M., Klockgether T., Wüllner U., et al. Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6. Cerebellum 2010, 9:433-442.
5. Braga-Neto P., Pedroso J.L., Alessi H., Dutra L.A., Felício A.C., Minett T., et al. Cerebellar cognitive affective syndrome in Machado Joseph disease: core clinical features October 2011, vol. 6. Cerebellum published online. 10.1007/s12311-011-0318-6.
6. Kehagia A.A., Barker R.A., Robbins T.W. Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol 2010, 9:1200-1213.
7. Doty R.L. Olfaction in Parkinson's disease. Parkinsonism Relat Disord 2007, 13(Suppl. 3):S225-S228.
8. Velázquez-Pérez L., Fernandez-Ruiz J., Díaz R., Díaz R., González R.P., Ochoa N.C., et al. Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases. J Neurol 2006, 253:1165-1169.
9. 99mTc]TRODAT-1: a novel technetium-99m complex as a dopamine transporter imaging agent. Eur J Nucl Med 1997, 24:372-380.
10. Yen T.C., Tzen K.Y., Wey S.P., Ting G. Decreased dopamine transporter binding in Machado-Joseph disease. J Nucl Med 2000, 41:994-998.
11. Yen T.C., Tzen K.Y., Chen M.C., Chou Y.H., Chen R.S., Chen C.J., et al. Dopamine transporter concentration is reduced in asymptomatic Machado-Joseph disease gene carriers. J Nucl Med 2002, 43:153-159.
12. Taniwaki T., Sakai T., Kobayashi T., Kuwabara Y., Otsuka M., Ichiya Y., et al. Positron emission tomography (PET) in Machado-Joseph disease. J Neurol Sci 1997, 145:63-67.
13. Cubo E., López M.D., Ceberio J.I., Alfonso I.L., Martinez B.M., Berciano J., et al. Striatal dopamine function in a family with multiple SCA-3 phenotypes. J Neurol 2011, 258:308-310.
14. Lu C.S., Chang H.C., Kuo P.C., Liu Y.L., Wu W.S., Weng Y.H., et al. The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family. Parkinsonism Relat Disord 2004, 10:369-373.
15. Rub U., Brunt E.R., Deller T. New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease). Curr Opin Neurol 2008, 21:111-116.
16. Shinotoh H., Thiessen B., Snow B.J., Hashimoto S., MacLeod P., Silveira I., et al. Fluorodopa and raclopride PET analysis of patients with Machado-Joseph disease. Neurology 1997, 49:1133-1136.
17. 11C]raclopride positron emission tomography. Mov Disord 2006, 21:1667-1673.
18. Piccini P.P. Dopamine transporter: basic aspects and neuroimaging. Mov Disord 2003, 18:3-8.
19. Filippi L., Manni C., Pierantozzi M., Brusa L., Danieli R., Stanzione P., et al. 123I-FP-CIT semi-quantitative SPECT detects preclinical bilateral dopaminergic deficit in early Parkinson's disease with unilateral symptoms. Nucl Med Commun 2005, 26:421-426.
20. Flagel S.B., Clark J.J., Robinson T.E., Mayo L., Czuj A., Willuhn I., et al. A selective role for dopamine in stimulus-reward learning. Nature 2011, 469:53-57.
21. Cools R. Dopaminergic control of the striatum for high-level cognition. Curr Opin Neurobiol 2011, 21:402-407.
22. Lewis S., Slabosz A., Robbins T., Barker R., Owen A. Dopaminergic basis for deficits in working memory but not attentional set shifting in Parkinson's disease. Neuropsychologia 2005, 43:823-832.
23. Stoodley C.J., Schmahmann J.D. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 2010, 46:831-844.
24. Goti D., Katzen S.M., Mez J., Kurtis N., Kiluk J., Ben-Haïem L., et al. A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration. J Neurosci 2004, 24:10266-10279.
25. Sobel N., Prabhakaran V., Hartley C.A., Desmond J.E., Zhao Z., Glover G.H., et al. Odorant-induced and sniff-induced activation in the cerebellum of the human. J Neurosci 1998, 18:8990-9001.
26. Qureshy A., Kawashima R., Imran M.B., Sugiura M., Goto R., Okada K., et al. Functional mapping of human brain in olfactory processing: a PET study. J Neurophysiol 2000, 84:1656-1666.