FOXP3 is not mutated in human melanoma

Pigment Cell and Melanoma Research

Volumn 25, Issue 3, 2012, Pages 398-400

  Tan, BeeShin ^a   Behren, Andreas ^a   Anaka, Matthew ^a   Vella, Laura ^a   Cebon, Jonathan ^a   Mariadason, John M ^a   Chen, Weisan ^a  

^a OLIVIA NEWTON JOHN CANCER RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

BREAST CANCER; BREAST EPITHELIUM; CANCER INHIBITION; CANCER INVASION; EFFECTOR CELL; GENE MUTATION; HUMAN; IN VITRO STUDY; LETTER; MELANOMA; OVARY; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; FEMALE; GENETICS; MALE; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SKIN TUMOR; TUMOR CELL LINE; X CHROMOSOME;

BASE SEQUENCE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, X; DNA MUTATIONAL ANALYSIS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; MELANOMA; MOLECULAR SEQUENCE DATA; MUTATION; SKIN NEOPLASMS;

EID: 84865314647     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2012.00993.x     Document Type: Letter

References (12)

1. Brunkow, M.E., Jeffery, E.W., Hjerrild, K.A., Paeper, B., Clark, L.B., Yasayko, S.A., Wilkinson, J.E., Galas, D., Ziegler, S.F., and Ramsdell, F. (2001). Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73.
2. Curtin, J.A., Fridlyand, J., Kageshita, T. et al. (2005). Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135-2147.
3. Ebert, L.M., Tan, B.S., Browning, J. et al. (2008). The regulatory t cell-associated transcription factor foxp3 is expressed by tumor cells. Cancer Res. 68, 3001-3009.
4. Gavin, M.A., Rasmussen, J.P., Fontenot, J.D., Vasta, V., Manganiello, V.C., Beavo, J.A., and Rudensky, A.Y. (2007). Foxp3-dependent programme of regulatory t-cell differentiation. Nature 445, 771-775.
5. Hinz, S., Pagerols-Raluy, L., Oberg, H.H. et al. (2007). Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res. 67, 8344-8350.
6. Kim, M.S., Chung, N.G., Yoo, N.J., and Lee, S.H. (2011a). No mutation in the foxp3 gene in acute leukemias. Leuk. Res. 35, e10.
7. Kim, M.S., Yoo, N.J., and Lee, S.H. (2011b). Absence of tumour suppressor foxp3 gene mutation in prostate cancers of korean patients. Pathology 43, 287.
8. Quaglino, P., Osella-Abate, S., Marenco, F., Nardo, T., Gado, C., Novelli, M., Savoia, P., and Bernengo, M.G. (2011). Foxp3 expression on melanoma cells is related to early visceral spreading in melanoma patients treated by electrochemotherapy. Pigment Cell Melanoma Res. 24, 734-736.
9. Wang, L., Liu, R., Li, W. et al. (2009). Somatic single hits inactivate the x-linked tumor suppressor foxp3 in the prostate. Cancer Cell 16, 336-346.
10. Wang, W.H., Jiang, C.L., Yan, W. et al. (2010). Foxp3 expression and clinical characteristics of hepatocellular carcinoma. World J. Gastroenterol. 16, 5502-5509.
11. Zhang, H.Y., and Sun, H. (2010). Up-regulation of foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer. Cancer Lett. 287, 91-97.
12. Zuo, T., Wang, L., Morrison, C. et al. (2007). Foxp3 is an x-linked breast cancer suppressor gene and an important repressor of the her-2/erbb2 oncogene. Cell 129, 1275-1286.