Effect of extra-column volume on practical chromatographic parameters of sub-2-μm particle-packed columns in ultra-high pressure liquid chromatography

Journal of Separation Science

Volumn 35, Issue 16, 2012, Pages 2018-2025

  Wu, Naijun ^a   Bradley, Ashley C ^b   Welch, Christopher J ^a   Zhang, Li ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NORTH CAROLINA A AND T STATE UNIVERSITY   (United States)

Author keywords

Band broadening; Extra column volume; Pressure drop; Retention factors; Ultra high performance liquid chromatography

Indexed keywords

BAND-BROADENING; COLUMN EFFICIENCY; EXTRA-COLUMN VOLUME; INTERNAL DIAMETERS; ISOCRATIC CONDITIONS; LIQUID CHROMATOGRAPHY SYSTEM; LONG COLUMN; MAXIMUM RATIO; OPTIMUM FLOW; RETENTION FACTORS; SEPARATION PARAMETERS; ULTRA-HIGH PERFORMANCE; ULTRAHIGH PRESSURE; VOID VOLUME;

CHROMATOGRAPHY; EFFICIENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRESSURE DROP; TUBING;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; FLOW RATE; PARTICLE SIZE; PRESSURE; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MODELS, THEORETICAL;

EID: 84865313284     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200074     Document Type: Article

References (30)

1. MacNair, J. E., Lewis, K. C., Jorgenson, J. W., Anal. Chem. 1997, 69, 983-989.
2. MacNair, J. E., Patel, K. D., Jorgenson, J. W., Anal. Chem. 1999, 71, 700-708.
3. Lippert, A. J., Xin, B., Wu, N., Lee, M. L., J. Microcolumn 1999, 631-643.
4. Wu, N., Collins, D. C., Lippert, A. J., Xiang, Y., Lee, M. L., J. Microcolumn 2000, 462-469.
5. Wu, N., Lippert, A. J., Lee, M. L., J. Chromatogr. 2001, 911, 1-12
6. Mazzeo, J. R., Neue, U. D., Kele, M., Plumb, R. S., Anal. Chem. 2005, 77, 460A-467A.
7. Halasz, I., Endele, R., Asshauer, J., J. Chromatogr. 1975, 112, 37-60.
8. Lin, H.-J., Horvath, C. S., Chem. Eng. Sci. 1981, 36, 47-55.
9. Gritti, F., Guiochon, G., J. Chromatogr. A 2007, 1138, 141-157.
10. Gritti, F., Martin, M., Guiochon, G., Anal. Chem. 2009, 81, 3365-3384.
11. Colon, L. A., Cintron, J. M., Anspach, J. A., Fermier, A. M., Swinney, K. A., Analyst 2004, 129, 503-504.
12. Welch, C. J., Wu, N., Biba, M., Hartman, R., Brkovic, T., Gong, X., Helmy, R., Schafer, W., Cuff, J. F., Pirzada, Z., Zhou, L., Trends Anal. Chem. 2010, 77, 667-680.
13. Chen, S., Kord, A., J. Chromatogr. A 2009, 1216, 6204-6209.
14. Yeung, E.S., Novotny, M.V., Ishii, D., Journal of Chromatography Library Series, Vol.: Microlumn Separations, Elsevier, Amsterdam 1985, p. 117.
15. Gritti, F., Guiochon, G., J. Chromatogr. A 2012, 1228, 2-19.
16. Fountain, K. J., Neue, U. D., Grumbach, E. S., Diehl, D. M., J. Chromatogr. A 2009, 1216, 5979-5988.
17. Usher, K. M., Simmons, C. R., Dorsey, J. G., J. Chromatogr. A 2008, 1200, 122-128.
18. Cabooter, D., Billen, J., Terryn, H., Lynen, F., Sandra, P., Desmet, G., J. Chromatogr. A 2008, 1204, 1-10.
19. Cabooter, D., deVilliers, A., Clicq, D., Szucs, R., Sandra, P., Desmet, G., J. Chromatogr. A 2007, 1147, 183-191.
20. Grittia, F., Felinger, A., Guiochon, G., J. Chromatogr. A 2006, 1136, 57-72.
21. Prüá, A., Kempter, C., Gysler, J., Jira, T., J. Chromatogr. A 2003, 1016, 129-141.
22. Alexander, A. J., Waeghe, T. J., Himes, K. W., Tomasella, F. P., Hooker, T. F., J. Chromatogr. A 2011, 1218, 5456-5469.
23. Giddings, J. C., Unified Separation Science, John Wiley & Sons, Inc, New York 1991, p. 65.
24. Van Deemter, J. J., Zuiderweg, F. J., Kinkenberg, A., Chem. Eng. Sci. 1956, 5, 271-289.
25. Snyder, L. R., Kirkland, J. J., Introduction to Modern Liquid Chromatography, John Wiley, New York 1979.
26. Krejci, M., Trace Analysis with Microcolumn Liquid Chromatography, Marcel Dekker, New York 1992, p. 35.
27. Grittia, F., Guiochon, G., J. Chromatogr. A 2010, 1217, 7677-7689.
28. McCalley, D. V., J. Chromatogr. A 2010, 1217, 4561-4567.
29. Lestremau, F., Wu, D., Szücs, R., J. Chromatogr. A 2010, 1217, 4925-4933.
30. Li, J., Carr, P. W., Anal. Chem. 1997, 69, 2530-2536.