In vivo comparison of harmine efficacy against psychostimulants: Preferential inhibition of the cocaine response through a glutamatergic mechanism

Neuroscience Letters

Volumn 525, Issue 1, 2012, Pages 12-16

  Owaisat, Suzan ^a   Raffa, Robert B ^a   Rawls, Scott M ^b,c  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carboline; Cocaine; Glutamate; Harmine; Mephedrone; Planaria

Indexed keywords

4' METHYLMETHCATHINONE; COCAINE; DIHYDROKAINIC ACID; GLUTAMIC ACID; HARMINE; METHAMPHETAMINE; N METHYL DEXTRO ASPARTIC ACID; NICOTINE;

ARTICLE; ATTENUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG EFFICACY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; TURBELLARIA;

AMPHETAMINES; ANIMALS; COCAINE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HARMINE; INHIBITION (PSYCHOLOGY); KAINIC ACID; NICOTINE; NICOTINIC ANTAGONISTS; PLANARIANS; PSYCHOTROPIC DRUGS;

EID: 84865311648     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.07.052     Document Type: Article

References (39)

1. Allen M.S., LaLoggia A.J., Dorn L.J., Martin M.J., Costantino G., Hagen T.J., Koehler K.F., Skolnick P., Cook J.M. Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. Journal of Medicinal Chemistry 1992, 35:4001-4010.
2. Aricioglu-Kartal F., Kayir H., Tayfun Uzbay I. Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats. Life Sciences 2003, 73:2363-2371.
3. Baumann M.H., Ayestas M.A., Partilla J.S., Sink J.R., Shulgin A.T., Daley P.F., Brandt S.D., Rothman R.B., Ruoho A.E., Cozzi N.V. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 2012, 37:1192-1203.
4. Cappendijk S.L., Fekkes D., Van Dalen A., Pepplinkhuizen L. The acute effects of norharman on cocaine self-administration and sensorimotor function in male Wistar rats. European Neuropsychopharmacology 2001, 11:233-239.
5. Cebria F., Kudome T., Nakazawa M., Mineta K., Ikeo K., Gojobori T., Agata K. The expression of neural-specific genes reveals the structural and molecular complexity of the planarian central nervous system. Mechanisms of Development 2002, 116:199-204.
6. Eriksson K.S., Panula P. gamma-Aminobutyric acid in the nervous system of a planarian. Journal of Comparative Neurology 1994, 345:528-536.
7. Farzin D., Haghparast A., Motaman S., Barya F., Mansouri N. Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat. Pharmacology Biochemistry and Behavior 2011, 98:215-219.
8. Ginovart N., Meyer J.H., Boovariwala A., Hussey D., Rabiner E.A., Houle S., Wilson A.A. Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain. Journal of Cerebral Blood Flow and Metabolism 2006, 26:330-344.
9. Glennon R.A., Dukat M., Grella B., Hong S., Costantino L., Teitler M., Smith C., Egan C., Davis K., Mattson M.V. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug and Alcohol Dependence 2000, 60:121-132.
10. Green A.L. The human brain. Inhibition of rat and mouse brain monamine oxidases by (+)-amphetamine. Biochemical Journal 1971, 121:37P-38P.
11. Hadlock G.C., Webb K.M., McFadden L.M., Chu P.W., Ellis J.D., Allen S.C., Andrenyak D.M., Vieira-Brock P.L., German C.L., Conrad K.M., Hoonakker A.J., Gibb J.W., Wilkins D.G., Hanson G.R., Fleckenstein A.E. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. Journal of Pharmacology and Experimental Therapeutics 2011, 339:530-536.
12. P.K. Huang, S.M. Aarde, D. Angrish, K.L. Houseknecht, T.J. Dickerson, M.A. Taffe, Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats. Drug and Alcohol Dependence, in press, . doi:10.1016/j.drugalcdep.2012.05.011.
13. Husbands S.M., Glennon R.A., Gorgerat S., Gough R., Tyacke R., Crosby J., Nutt D.J., Lewis J.W., Hudson A.L. Beta-carboline binding to imidazoline receptors. Drug and Alcohol Dependence 2001, 64:203-208.
14. Kehr J., Ichinose F., Yoshitake S., Goiny M., Sievertsson T., Nyberg F., Yoshitake T. Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats. British Journal of Pharmacology 2011, 164:1949-1958.
15. Kim H., Sablin S.O., Ramsay R.R. Inhibition of monoamine oxidase A by beta-carboline derivatives. Archives of Biochemistry and Biophysics 1997, 337:137-142.
16. Knackstedt L.A., Melendez R.I., Kalivas P.W. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological Psychiatry 2010, 67:81-84.
17. Koob G.F. Neural mechanisms of drug reinforcement. Annals of the New York Academy of Sciences 1992, 654:171-191. (Review).
18. Li Y., Sattler R., Yang E.J., Nunes A., Ayukawa Y., Akhtar S., Ji G., Zhang P.W., Rothstein J.D. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology 2011, 60:1168-1175.
19. Martinez-Clemente J., Escubedo E., Pubill D., Camarasa J. Interaction of mephedrone with dopamine and serotonin targets in rats. European Neuropsychopharmacology 2011, 22:231-236.
20. Nishimura K., Kitamura Y., Taniguchi T., Agata K. Analysis of motor function modulated by cholinergic neurons in planarian Dugesia japonica. Neuroscience 2010, 168:18-30.
21. Pagán O.R., Rowlands A.L., Azam M., Urban K.R., Bidja A.H., Roy D.M., Feeney R.B., Afshari L.K. Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. Pharmacology Biochemistry and Behavior 2008, 89:160-170.
22. Pagán O.R., Rowlands A.L., Fattore A.L., Coudron T., Urban K.R., Bidja A.H., Eterović V.A. A cembranoid from tobacco prevents the expression of nicotine-induced withdrawal behavior in planarian worms. European Journal of Pharmacology 2009, 615:118-124.
23. Parker C.A., Anderson N.J., Robinson E.S., Price R., Tyacke R.J., Husbands S.M., Dillon M.P., Eglan R.M., Hudson A.L., Nutt D.J., Crump M.P., Crosby J. Harmane and harmalan are bioactive components of classical clonidine-displacing substance. Biochemistry 2004, 43:16385-16392.
24. Raffa R.B., Rawls S.M. A Model for Drug Action and Abuse 2010, Landes Bioscience, Austin, TX.
25. Ramakrishnan L., Desaer C. Carbamazepine inhibits distinct chemoconvulsant-induced seizure-like activity in Dugesia tigrina. Pharmacology Biochemistry and Behavior 2011, 99:665-670.
26. Ramoz L., Lodi S., Bhatt P., Reitz A.B., Tallarida C., Tallarida R.J., Raffa R.B., Rawls S.M. Mephedrone (bath salt) pharmacology: insights from invertebrates. Neuroscience 2012, 208:79-84.
27. Rasmussen B., Unterwald E.M., Rawls S.M. Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats. Drug and Alcohol Dependence 2011, 118:484-488.
28. Rawls S.M., Cavallo F., Capasso A., Ding Z., Raffa R.B. The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians. European Journal of Pharmacology 2008, 584:278-284.
29. Rawls S.M., Karaca F., Madhani I., Bhojani V., Martinez R.L., Abou-Gharbia M., Raffa R.B. β-lactamase inhibitors display anti-seizure properties in an invertebrate assay. Neuroscience 2010, 169:1800-1804.
30. Rothstein J.D., Patel S., Regan M.R., Haenggeli C., Huang Y.H., Bergles D.E., Jin L., Dykes Hoberg M., Vidensky S., Chung D.S., Toan S.V., Bruijn L.I., Su Z.Z., Gupta P., Fisher P.B. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 2005, 433:73-77.
31. Ribeiro P., El-Shehabi F., Patocka N. Classical transmitters and their receptors in flatworms. Parasitology 2005, 131(Suppl.):S19-S40.
32. Song Y., Kesuma D., Wang J., Deng Y., Duan J., Wang J.H., Qi R.Z. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochemical and Biophysical Research Communications 2004, 317:128-132.
33. Tallarida C., Song K., Raffa R.B., Rawls S.M. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 2012, 42:2521-2524.
34. Venturini G., Stocchi F., Margotta V., Ruggieri S., Bravi D., Bellantuono P., Palladini G. A pharmacological study of dopaminergic receptors in planaria. Neuropharmacology 1989, 28:1377-1382.
35. Vyas C.A., Rawls S.M., Raffa R.B., Shackman J.G. Glutamate and aspartate measurements in individual planaria by rapid capillary electrophoresis. Journal of Pharmacological and Toxicological Methods 2010, 63:119-122.
36. Ward S.J., Rasmussen B.A., Corley G., Henry C., Kim J.K., Walker E.A., Rawls S.M. β-lactam antibiotic decreases acquisition of and motivation to respond for cocaine, but not sweet food, in C57Bl/6 mice. Behavioural Pharmacology 2011, 22:370-373.
37. Winstock A.R., Mitcheson L.R., Deluca P., Davey Z., Corazza O., Schifano F. Mephedrone, new kid for the chop?. Addiction 2011, 106:154-161.
38. Wood D.M., Davies S., Greene S.L., Button J., Holt D.W., Ramsey J., Dargan P.I. Case series of individuals with analytically confirmed acute mephedrone toxicity. Clinical Toxicology 2010, 48:924-927.
39. Young A.M., Bradford H.F. N-methyl-d-aspartate releases excitatory amino acids in rat corpus striatum in vivo. Journal of Neurochemistry 1991, 56:1677-1683.