Similar evolution of cellular HIV-1 DNA level in Darunavir/Ritonavir monotherapy versus triple therapy in MONOI -ANRS136 trial over 96 weeks

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Lambert Niclot, Sidonie ^a   Flandre, Philippe ^a   Valantin, Marc Antoine ^a   Soulie, Cathia ^a   Fourati, Slim ^a   Wirden, Marc ^a   Sayon, Sophie ^a   Pakianather, Sophie ^b   Bocket, Laurence ^c   Masquelier, Bernard ^d   Dos Santos, Georges ^e   Katlama, Christine ^a   Calvez, Vincent ^a   Marcelin, Anne Genevieve ^a  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b INSERM   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d HÔPITAL PELLEGRIN   (France)

^e Centre Hospitalier et Universitaire de Fort de France   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DARUNAVIR PLUS RITONAVIR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS DNA; VIRUS RNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CELL LEVEL; COMBINATION CHEMOTHERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INTERMITTENT VIREMIA; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PREDICTIVE VALUE; RANDOMIZED CONTROLLED TRIAL (TOPIC); VIREMIA; VIRUS LOAD;

ADULT; DNA, VIRAL; FEMALE; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MALE; MIDDLE AGED; RITONAVIR; RNA, VIRAL; SULFONAMIDES; VIRAL LOAD; VIREMIA;

EID: 84865293911     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041390     Document Type: Article

References (19)

1. Arribas JR, Horban A, Gerstoft J, Fatkenheuer G, Nelson M, et al. ((2010)) The MONET trial: darunavir/ritonavir with or without nucleoside analogues, for patients with HIV RNA below 50 copies/ml. Aids 24:: 223--230.
2. Delfraissy JF, Flandre P, Delaugerre C, Ghosn J, Horban A, et al. ((2008)) Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in antiretroviral-naive HIV-infected patients. Aids 22:: 385--393.
3. Meynard JL, Bouteloup V, Landman R, Bonnard P, Baillat V, et al. ((2010)) Lopinavir/ritonavir monotherapy versus current treatment continuation for maintenance therapy of HIV-1 infection: the KALESOLO trial. J Antimicrob Chemother.
4. Katlama C, Valantin MA, Algarte-Genin M, Duvivier C, Lambert-Niclot S, et al. ((2010)) Efficacy of darunavir/ritonavir maintenance monotherapy in patients with HIV-1 viral suppression: a randomized open-label, noninferiority trial, MONOI-ANRS 136. Aids 24:: 2365--2374.
5. Valantin MA, Lambert-Niclot S, Flandre P, Morand-Joubert L, Cabie A, et al. ((2012)) Long-term efficacy of darunavir/ritonavir monotherapy in patients with HIV-1 viral suppression: week 96 results from the MONOI ANRS 136 study. J Antimicrob Chemother 67(3):: 691--5.
6. EACS European AIDS Clinical Society. April 2011, 5-4. 2011, posting date. Clinical Management and Treatment of HIV-infected Adults in Europe. http://www.europeanaidsclinicalsociety.org/guidelinespdf/1_Treatment_of_ HIV_Infected_Adults.pdf Last accessed.
7. Pulido F, Arribas JR, ((2008)) Noninferiority and lopinavir/ritonavir monotherapy trials. Aids 22:: 1696--1697.
8. Morand-Joubert L, Marcellin F, Launay O, Guiramand-Hugon S, Gerard L, et al. ((2005)) Contribution of cellular HIV-1 DNA quantification to the efficacy analysis of antiretroviral therapy: a randomized comparison of 2 regimens, including 3 drugs from 2 or 3 classes (TRIANON, ANRS 081). J Acquir Immune Defic Syndr 38:: 268--276.
9. Viard JP, Burgard M, Hubert JB, Aaron L, Rabian C, et al. ((2004)) Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level. Aids 18:: 45--49.
10. Avettand-Fenoel V, Flandre P, Chaix ML, Ghosn J, Delaugerre C, et al. ((2010)) Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial. J Antimicrob Chemother 65:: 1005--1007.
11. Lambert-Niclot S, Flandre P, Valantin MA, Peytavin G, Duvivier C, et al. ((2011)) Factors associated with virological failure in HIV-1-infected patients receiving darunavir/ritonavir monotherapy. J Infect Dis 204:: 1211--1216.
12. Palmer S, Wiegand AP, Maldarelli F, Bazmi H, Mican JM, et al. ((2003)) New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 41:: 4531--4536.
13. Avettand-Fenoel V, Chaix ML, Blanche S, Burgard M, Floch C, et al. ((2009)) LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01). J Med Virol 81:: 217--223.
14. Burgard M, Boufassa F, Viard JP, Garrigue I, Ruffault A, et al. ((2009)) Factors influencing peripheral blood mononuclear cell-associated HIV-1 DNA level after long-term suppressive antiretroviral therapy in 236 patients. Aids 23:: 2165--2171.
15. Burgard M, Izopet J, Dumon B, Tamalet C, Descamps D, et al. ((2000)) HIV RNA and HIV DNA in peripheral blood mononuclear cells are consistent markers for estimating viral load in patients undergoing long-term potent treatment. AIDS Res Hum Retroviruses 16:: 1939--1947.
16. Hatzakis AE, Touloumi G, Pantazis N, Anastassopoulou CG, Katsarou O, et al. ((2004)) Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy. Aids 18:: 2261--2267.
17. Havlir DV, Strain MC, Clerici M, Ignacio C, Trabattoni D, et al. ((2003)) Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years. J Virol 77:: 11212--11219.
18. Hoen B, Cooper DA, Lampe FC, Perrin L, Clumeck N, et al. ((2007)) Predictors of virological outcome and safety in primary HIV type 1-infected patients initiating quadruple antiretroviral therapy: QUEST GW PROB3005. Clin Infect Dis 45:: 381--390.
19. Chun TW, Murray D, Justement JS, Hallahan CW, Moir S, et al. ((2011)) Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis 204:: 135--138.