Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13544-13548

  Bobst, Cedric E ^a   Wang, Shunhai ^a   Shen, Wei Chiang ^b   Kaltashov, Igor A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Electrospray ionization; Native electrospray ionization MS; Protein therapeutic; Protein receptor interaction; Recombinant fusion protein

Indexed keywords

GROWTH HORMONE TRANSFERRIN FUSION PROTEIN; HYBRID PROTEIN; MONOMER; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; EMBRYO; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MASS SPECTROMETRY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; STOMACH PROTECTION; TRANSCYTOSIS;

ADMINISTRATION, ORAL; CHROMATOGRAPHY; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; HYDROLYSIS; KINETICS; LIGHT; MASS SPECTROMETRY; PEPSIN A; PROTEINS; PROTEOLYSIS; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSFERRIN;

EID: 84865292517     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206924109     Document Type: Article

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