Loss of vascular early response gene reduces edema formation after experimental stroke

Experimental and Translational Stroke Medicine

Volumn 4, Issue 1, 2012, Pages

  Liu, Fudong ^a   Turtzo, L C ^a   Li, Jun ^a   Regard, Jean ^b   Worley, Paul ^b,c   Zeevi, Neer ^a   McCullough, Louise D ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Edema; Ischemic stroke; Middle cerebral artery occlusion (MCAO); Neurological deficit score

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; C57BL 6 MOUSE; CONTROLLED STUDY; GENE; GENE DELETION; GENE LOSS; GENOTYPE; KNOCKOUT MOUSE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SCORING SYSTEM; VASCULAR EARLY RESPONSE GENE; WILD TYPE;

EID: 84865291054     PISSN: None     EISSN: 20407378     Source Type: Journal    
DOI: 10.1186/2040-7378-4-12     Document Type: Article

References (18)

1. Jung JE, Kim GS, Chen H, Maier CM, Narasimhan P, Song YS, Niizuma K, Katsu M, Okami N, Yoshioka H, et al. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol 2010, 41(2-3):172-179. 2877155, 20157789.
2. Banks WA. Mouse models of neurological disorders: a view from the blood-brain barrier. Biochim Biophys Acta 2009, 1802(10):881-888. 2891624, 19879356.
3. Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda) 2009, 24:257-265.
4. Fowler T, Sen R, Roy AL. Regulation of primary response genes. Mol Cell 2011, 44(3):348-360. 10.1016/j.molcel.2011.09.014, 22055182.
5. O'Donnell A, Odrowaz Z, Sharrocks AD. Immediate-early gene activation by the MAPK pathways: what do and don't we know?. Biochem Soc Trans 2012, 40(1):58-66. 10.1042/BST20110636, 22260666.
6. Weinstein PR, Hong S, Sharp FR. Molecular identification of the ischemic penumbra. Stroke 2004, 35(11 Suppl 1):2666-2670.
7. Liu PK. Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury. J Biomed Sci 2003, 10(1):4-13. 10.1007/BF02255992, 2695961, 12566981.
8. Sandoval KE, Witt KA. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 2008, 32(2):200-219. 10.1016/j.nbd.2008.08.005, 18790057.
9. Regard JB, Scheek S, Borbiev T, Lanahan AA, Schneider A, Demetriades AM, Hiemisch H, Barnes CA, Verin AD, Worley PF. Verge: a novel vascular early response gene. J Neurosci 2004, 24(16):4092-4103. 10.1523/JNEUROSCI.4252-03.2004, 15102925.
10. Maallem S, Wierinckx A, Lachuer J, Kwon MH, Tappaz ML. Gene expression profiling in brain following acute systemic hypertonicity: novel genes possibly involved in osmoadaptation. J Neurochem 2008, 105(4):1198-1211. 10.1111/j.1471-4159.2008.05222.x, 18194432.
11. Liu F, Schafer DP, McCullough LD. TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion. J Neurosci Methods 2009, 179(1):1-8. 10.1016/j.jneumeth.2008.12.028, 2674851, 19167427.
12. Liu F, Akella P, Benashski SE, Xu Y, McCullough LD. Expression of Na-K-Cl cotransporter and edema formation are age dependent after ischemic stroke. Exp Neurol 2010, 224(2):356-361. 10.1016/j.expneurol.2010.04.010, 2906683, 20406636.
13. Liu F, Benashski SE, Persky R, Xu Y, Li J, McCullough LD. Age-related changes in AMP-activated protein kinase after stroke. Age (Dordr) 2012, 34(1):157-68.
14. Liu F, Yuan R, Benashski SE, McCullough LD. Changes in experimental stroke outcome across the life span. J Cereb Blood Flow Metab 2009, 29(4):792-802. 10.1038/jcbfm.2009.5, 2748430, 19223913.
15. Liu F, Li Z, Li J, Siegel C, Yuan R, McCullough LD. Sex differences in caspase activation after stroke. Stroke 2009, 40(5):1842-1848. 10.1161/STROKEAHA.108.538686, 2674515, 19265047.
16. Gerlai R. Gene targeting: technical confounds and potential solutions in behavioral brain research. Behav Brain Res 2001, 125(1-2):13-21.
17. Madej-Fermo OP, Staff I, Fortunato G, Abbott L, McCullough LD. Impact of emergency department transitions of care on thrombolytic use in acute ischemic stroke. Stroke 2012, 43(4):1067-1074. 10.1161/STROKEAHA.111.643437, 22282889.
18. Hayashi T, Abe K, Suzuki H, Itoyama Y. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 1997, 28(10):2039-2044. 10.1161/01.STR.28.10.2039, 9341716.