How to discriminate contamination from bloodstream infection due to coagulase-negative staphylococci: A prospective study with 654 patients

Clinical Microbiology and Infection

Volumn 18, Issue 9, 2012, Pages

  Elzi, L ^a   Babouee, B ^a   Vogeli N ^a   Laffer, R ^b   Dangel, M ^a   Frei, R ^a   Battegay, M ^a   Widmer, A F ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Regional Hospital Oberaargau   (Switzerland)

Author keywords

Bloodstream infection; Central venous catheter; Coagulase negative staphylococci; Contamination; Systemic inflammatory response syndrome criteria

Indexed keywords

BETA LACTAM ANTIBIOTIC; GLYCOPEPTIDE; OXACILLIN; VANCOMYCIN;

ADULT; AGED; ARTICLE; BACTEREMIA; BACTERIUM CONTAMINATION; BLOOD CULTURE; BLOODSTREAM INFECTION; CENTRAL VENOUS CATHETER; COAGULASE NEGATIVE STAPHYLOCOCCUS; FEMALE; FEVER; HUMAN; HYPOTHERMIA; LEUKOCYTOSIS; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TACHYCARDIA; TACHYPNEA;

STAPHYLOCOCCUS;

EID: 84865290272     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2012.03964.x     Document Type: Article

References (37)

1. Jarvis WR, Martone WJ. Predominant pathogens in hospital infections. J Antimicrob Chemother 1992; 29 (suppl A): 19-24.
2. Pittet D, Wenzel RP. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med 1995; 155: 1177-1184.
3. Thylefors JD, Harbarth S, Pittet D. Increasing bacteremia due to coagulase-negative staphylococci: fiction or reality? Infect Control Hosp Epidemiol 1998; 19: 581-589.
4. Herwaldt LA, Geiss M, Kao C, Pfaller MA. The positive predictive value of isolating coagulase-negative staphylococci from blood cultures. Clin Infect Dis 1996; 22: 14-20.
5. Rogers KL, Fey PD, Rupp ME. Coagulase-negative staphylococcal infections. Infect Dis Clin North Am 2009; 23: 73-98.
6. Morris JG Jr, Shay DK, Hebden JN et al. Enterococci resistant to multiple antimicrobial agents, including vancomycin. Establishment of endemicity in a university medical center. Ann Intern Med 1995; 123: 250-259.
7. O'Grady NP, Alexander M, Dellinger EP et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for disease control and prevention. MMWR Recomm Rep 2002; 51: 1-29.
8. Bates DW, Goldman L, Lee TH. Contaminant blood cultures and resource utilization. The true consequences of false-positive results. JAMA 1991; 265: 365-369.
9. Weinstein MP. Blood culture contamination: persisting problems and partial progress. J Clin Microbiol 2003; 41: 2275-2278.
10. Seybold U, Reichardt C, Halvosa JS, Blumberg HM. Clonal diversity in episodes with multiple coagulase-negative staphylococcus bloodstream isolates suggesting frequent contamination. Infection 2009; 37: 256-260.
11. Bjorkqvist M, Soderquist B, Tornqvist E et al. Phenotypic and genotypic characterisation of blood isolates of coagulase-negative staphylococci in the newborn. APMIS 2002; 110: 332-339.
12. Toldos CM, Yague G, Ortiz G, Segovia M. Assessment of multiple coagulase-negative staphylococci isolated in blood cultures using pulsed-field gel electrophoresis. Eur J Clin Microbiol Infect Dis 1997; 16: 581-586.
13. Souvenir D, Anderson DE Jr, Palpant S et al. Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol 1998; 36: 1923-1926.
14. MacGregor RR, Beaty HN. Evaluation of positive blood cultures. Guidelines for early differentiation of contaminated from valid positive cultures. Arch Intern Med 1972; 130: 84-87.
15. Finkelstein R, Fusman R, Oren I, Kassis I, Hashman N. Clinical and epidemiologic significance of coagulase-negative staphylococci bacteremia in a tertiary care university Israeli hospital. Am J Infect Control 2002; 30: 21-25.
16. Beekmann SE, Diekema DJ, Doern GV. Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures. Infect Control Hosp Epidemiol 2005; 26: 559-566.
17. Richter SS, Beekmann SE, Croco JL et al. Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm. J Clin Microbiol 2002; 40: 2437-2444.
18. Archer GL. Coagulase-negative staphylococci in blood cultures: the clinician's dilemma. Infect Control 1985; 6: 477-478.
19. Garcia P, Benitez R, Lam M et al. Coagulase-negative staphylococci: clinical, microbiological and molecular features to predict true bacteraemia. J Med Microbiol 2004; 53: 67-72.
20. Khatib R, Riederer K, Saeed S et al. Time to positivity in Staphylococcus aureus bacteremia: possible correlation with the source and outcome of infection. Clin Infect Dis 2005; 41: 594-598.
21. Kotilainen P. Association of coagulase-negative staphylococcal slime production and adherence with the development and outcome of adult septicemias. J Clin Microbiol 1990; 28: 2779-2785.
22. Seo SK, Venkataraman L, DeGirolami PC, Samore MH. Molecular typing of coagulase-negative staphylococci from blood cultures does not correlate with clinical criteria for true bacteremia. Am J Med 2000; 109: 697-704.
23. Bone RC, Balk RA, Cerra FB et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655.
24. Strecker EP, Ostheim-Dzerowycz W, Boos IB. Intraarterial infusion therapy via a subcutaneous port for limb-threatening ischemia: a pilot study. Cardiovasc Intervent Radiol 1998; 21: 109-115.
25. Pittet D, Li N, Wenzel RP. Association of secondary and polymicrobial nosocomial bloodstream infections with higher mortality. Eur J Clin Microbiol Infect Dis 1993; 12: 813-819.
26. Thorpe TC, Wilson ML, Turner JE et al. Bact/alert: an automated colorimetric microbial detection system. J Clin Microbiol 1990; 28: 1608-1612.
27. Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA. Manual of Clinical Microbiology, 9th edn. Washington, DC.: American Society for Microbiology, 2007.
28. Dominguez-de Villota E, Algora-Weber A, Millan I, Rubio JJ, Galdos P, Mosquera JM. Early evaluation of coagulase negative staphylococcus in blood samples of intensive care unit patients. A clinically uncertain judgement. Intensive Care Med 1987; 13: 390-394.
29. Bossink AW, Groeneveld AB, Hack CE, Thijs LG. The clinical host response to microbial infection in medical patients with fever. Chest 1999; 116: 380-390.
30. Vincent JL. Dear Sirs, I'm sorry to say that I don't like you. Crit Care Med 1997; 25: 372-374.
31. Pittet D, Harbarth S, Ruef C et al. Prevalence and risk factors for nosocomial infections in four university hospitals in Switzerland. Infect Control Hosp Epidemiol 1999; 20: 37-42.
32. Nataro JP, Corcoran L, Zirin S et al. Prospective analysis of coagulase-negative staphylococcal infection in hospitalized infants. J Pediatr 1994; 125: 798-804.
33. Vincent JL, Bihari DJ, Suter PM et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) study. EPIC International Advisory Committee. JAMA 1995; 274: 639-644.
34. Ponce de Leon S, Wenzel RP. Hospital-acquired bloodstream infections with Staphylococcus epidermidis. Review of 100 cases. Am J Med 1984; 77: 639-644.
35. Marra AR, Camargo LF, Pignatari AC et al. Nosocomial bloodstream infections in Brazilian hospitals: analysis of 2, 563 cases from a prospective nationwide surveillance study. J Clin Microbiol 2011; 49: 1866-1871.
36. Widmer A. Intravenous-related infections. In: Wenzel RP, ed. Prevention and control of nosocomial infections. Baltimore, MD: Williams & Wilkins, 1997; 771-805.
37. Mirrett S, Weinstein MP, Reimer LG, Wilson ML, Reller LB. Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. J Clin Microbiol 2001; 39: 3279-3281.