-
1
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
10.1016/j.cell.2007.06.009, 2756685, 17604717
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274. 10.1016/j.cell.2007.06.009, 2756685, 17604717.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
2
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
10.1126/science.279.5351.710, 9445477
-
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998, 279:710-714. 10.1126/science.279.5351.710, 9445477.
-
(1998)
Science
, vol.279
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
Gaffney, P.R.7
Reese, C.B.8
McCormick, F.9
Tempst, P.10
Coadwell, J.11
Hawkins, P.T.12
-
3
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
10.1016/j.semcdb.2003.12.022, 15209375
-
Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 2004, 15:161-170. 10.1016/j.semcdb.2003.12.022, 15209375.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.3
Alessi, D.R.4
-
4
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
10.1126/science.1106148, 15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101. 10.1126/science.1106148, 15718470.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
5
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
10.1074/jbc.273.22.13375, 9593664
-
Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998, 273:13375-13378. 10.1074/jbc.273.22.13375, 9593664.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
6
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
10.1016/j.ccr.2009.06.006, 2957372, 19647222
-
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009, 16:115-125. 10.1016/j.ccr.2009.06.006, 2957372, 19647222.
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
Bowtell, D.6
Barretina, J.7
Lin, W.M.8
Rameh, L.9
Salmena, L.10
Pandolfi, P.P.11
Cantley, L.C.12
-
7
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
10.1074/jbc.272.50.31515, 9395488
-
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997, 272:31515-31524. 10.1074/jbc.272.50.31515, 9395488.
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
8
-
-
34249993765
-
Integrative genomic approaches identify IKBKE as a breast cancer oncogene
-
10.1016/j.cell.2007.03.052, 17574021
-
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007, 129:1065-1079. 10.1016/j.cell.2007.03.052, 17574021.
-
(2007)
Cell
, vol.129
, pp. 1065-1079
-
-
Boehm, J.S.1
Zhao, J.J.2
Yao, J.3
Kim, S.Y.4
Firestein, R.5
Dunn, I.F.6
Sjostrom, S.K.7
Garraway, L.A.8
Weremowicz, S.9
Richardson, A.L.10
Greulich, H.11
Stewart, C.J.12
Mulvey, L.A.13
Shen, R.R.14
Ambrogio, L.15
Hirozane-Kishikawa, T.16
Hill, D.E.17
Vidal, M.18
Meyerson, M.19
Grenier, J.K.20
Hinkle, G.21
Root, D.E.22
Roberts, T.M.23
Lander, E.S.24
Polyak, K.25
Hahn, W.C.26
more..
-
9
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
10.1101/gad.913901, 312770, 11544177
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001, 15:2203-2208. 10.1101/gad.913901, 312770, 11544177.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
10
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
10.1074/jbc.C100462200, 11533044
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001, 276:38349-38352. 10.1074/jbc.C100462200, 11533044.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
11
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
10.1126/science.292.5522.1728, 11387480
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001, 292:1728-1731. 10.1126/science.292.5522.1728, 11387480.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
12
-
-
20044382806
-
Role for Akt3/protein kinase Bgamma in attainment of normal brain size
-
10.1128/MCB.25.5.1869-1878.2005, 549378, 15713641
-
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 2005, 25:1869-1878. 10.1128/MCB.25.5.1869-1878.2005, 549378, 15713641.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.7
Szabolcs, M.8
de Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
13
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
10.1242/dev.01864, 15930105
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, Frahm J, Hemmings BA. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005, 132:2943-2954. 10.1242/dev.01864, 15930105.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
14
-
-
77953158079
-
Distinct biological roles for the akt family in mammary tumor progression
-
10.1158/0008-5472.CAN-10-0266, 2880222, 20424120
-
Dillon RL, Muller WJ. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res 2010, 70:4260-4264. 10.1158/0008-5472.CAN-10-0266, 2880222, 20424120.
-
(2010)
Cancer Res
, vol.70
, pp. 4260-4264
-
-
Dillon, R.L.1
Muller, W.J.2
-
15
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
10.1158/0008-5472.CAN-07-6854, 2680495, 18676830
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008, 68:6084-6091. 10.1158/0008-5472.CAN-07-6854, 2680495, 18676830.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
Neve, R.M.4
Kuo, W.L.5
Davies, M.6
Carey, M.7
Hu, Z.8
Guan, Y.9
Sahin, A.10
Symmans, W.F.11
Pusztai, L.12
Nolden, L.K.13
Horlings, H.14
Berns, K.15
Hung, M.C.16
van de Vijver, M.J.17
Valero, V.18
Gray, J.W.19
Bernards, R.20
Mills, G.B.21
Hennessy, B.T.22
more..
-
16
-
-
57449083437
-
The PIK3CA gene as a mutated target for cancer therapy
-
10.2174/156800908786733504, 2831175, 19075596
-
Gustin JP, Cosgrove DP, Park BH. The PIK3CA gene as a mutated target for cancer therapy. Curr Cancer Drug Targets 2008, 8:733-740. 10.2174/156800908786733504, 2831175, 19075596.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 733-740
-
-
Gustin, J.P.1
Cosgrove, D.P.2
Park, B.H.3
-
17
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
10.1038/nrd2926, 3142564, 19644473
-
Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009, 8:627-644. 10.1038/nrd2926, 3142564, 19644473.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
Zhao, J.J.4
-
18
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
10.1016/j.molcel.2005.10.033, 16307918
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005, 20:539-550. 10.1016/j.molcel.2005.10.033, 16307918.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
19
-
-
33645213629
-
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
-
10.1073/pnas.0511342103, 1390746, 16537497
-
Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A 2006, 103:4134-4139. 10.1073/pnas.0511342103, 1390746, 16537497.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4134-4139
-
-
Liu, H.1
Radisky, D.C.2
Nelson, C.M.3
Zhang, H.4
Fata, J.E.5
Roth, R.A.6
Bissell, M.J.7
-
20
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
10.1016/j.ccr.2008.11.003, 3038665, 19061837
-
Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008, 14:458-470. 10.1016/j.ccr.2008.11.003, 3038665, 19061837.
-
(2008)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
Xu, P.Z.4
Chen, M.L.5
Tonic, I.6
Unterman, T.7
Hay, N.8
-
21
-
-
84862859977
-
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
-
Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene 2011,
-
(2011)
Oncogene
-
-
Astle, M.V.1
Hannan, K.M.2
Ng, P.Y.3
Lee, R.S.4
George, A.J.5
Hsu, A.K.6
Haupt, Y.7
Hannan, R.D.8
Pearson, R.B.9
-
22
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
10.1016/j.cell.2009.11.007, 19945376
-
Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890. 10.1016/j.cell.2009.11.007, 19945376.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
23
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
10.1016/j.cell.2008.03.027, 2728032, 18485877
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715. 10.1016/j.cell.2008.03.027, 2728032, 18485877.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
24
-
-
66149131111
-
Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
-
10.1158/0008-5472.CAN-08-3343, 2664865, 19276366
-
Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, Haluska P, Ingle JN, Hartmann LC, Manjili MH, Radisky DC, Ferrone S, Knutson KL. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 2009, 69:2887-2895. 10.1158/0008-5472.CAN-08-3343, 2664865, 19276366.
-
(2009)
Cancer Res
, vol.69
, pp. 2887-2895
-
-
Santisteban, M.1
Reiman, J.M.2
Asiedu, M.K.3
Behrens, M.D.4
Nassar, A.5
Kalli, K.R.6
Haluska, P.7
Ingle, J.N.8
Hartmann, L.C.9
Manjili, M.H.10
Radisky, D.C.11
Ferrone, S.12
Knutson, K.L.13
-
25
-
-
60649089997
-
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
-
10.1016/j.ccr.2009.01.023, 19249678
-
Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 2009, 15:195-206. 10.1016/j.ccr.2009.01.023, 19249678.
-
(2009)
Cancer Cell
, vol.15
, pp. 195-206
-
-
Kudo-Saito, C.1
Shirako, H.2
Takeuchi, T.3
Kawakami, Y.4
-
26
-
-
67649969473
-
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
-
10.1371/journal.pbio.1000121, 2683567, 19492080
-
Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009, 7:e1000121. 10.1371/journal.pbio.1000121, 2683567, 19492080.
-
(2009)
PLoS Biol
, vol.7
-
-
Korkaya, H.1
Paulson, A.2
Charafe-Jauffret, E.3
Ginestier, C.4
Brown, M.5
Dutcher, J.6
Clouthier, S.G.7
Wicha, M.S.8
-
27
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
10.1083/jcb.200505087, 2171329, 16365168
-
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005, 171:1023-1034. 10.1083/jcb.200505087, 2171329, 16365168.
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
28
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
-
10.1158/0008-5472.CAN-06-3782, 17210696
-
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007, 67:167-177. 10.1158/0008-5472.CAN-06-3782, 17210696.
-
(2007)
Cancer Res
, vol.67
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
29
-
-
73349099030
-
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
-
10.1126/scisignal.2000356, 2862216, 19825827
-
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2009, 2:ra62. 10.1126/scisignal.2000356, 2862216, 19825827.
-
(2009)
Sci Signal
, vol.2
-
-
Iliopoulos, D.1
Polytarchou, C.2
Hatziapostolou, M.3
Kottakis, F.4
Maroulakou, I.G.5
Struhl, K.6
Tsichlis, P.N.7
-
30
-
-
67449136114
-
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
-
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res 2009, 69:5057-5064.
-
(2009)
Cancer Res
, vol.69
, pp. 5057-5064
-
-
Dillon, R.L.1
Marcotte, R.2
Hennessy, B.T.3
Woodgett, J.R.4
Mills, G.B.5
Muller, W.J.6
-
31
-
-
57749106585
-
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells
-
10.1158/0008-5472.CAN-08-0288, 2821873, 19074894
-
Lin HJ, Zuo T, Lin CH, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan PS, Cheng AL, Ostrowski MC, Huang TH. Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res 2008, 68:10257-10266. 10.1158/0008-5472.CAN-08-0288, 2821873, 19074894.
-
(2008)
Cancer Res
, vol.68
, pp. 10257-10266
-
-
Lin, H.J.1
Zuo, T.2
Lin, C.H.3
Kuo, C.T.4
Liyanarachchi, S.5
Sun, S.6
Shen, R.7
Deatherage, D.E.8
Potter, D.9
Asamoto, L.10
Lin, S.11
Yan, P.S.12
Cheng, A.L.13
Ostrowski, M.C.14
Huang, T.H.15
-
32
-
-
69349105634
-
PIK3CA mutation associates with improved outcome in breast cancer
-
10.1158/1078-0432.CCR-09-0632, 19671852
-
Kalinsky K, Jacks LM, Heguy A, Patil S, Drobnjak M, Bhanot UK, Hedvat CV, Traina TA, Solit D, Gerald W, Moynahan ME. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 2009, 15:5049-5059. 10.1158/1078-0432.CCR-09-0632, 19671852.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5049-5059
-
-
Kalinsky, K.1
Jacks, L.M.2
Heguy, A.3
Patil, S.4
Drobnjak, M.5
Bhanot, U.K.6
Hedvat, C.V.7
Traina, T.A.8
Solit, D.9
Gerald, W.10
Moynahan, M.E.11
-
33
-
-
34547651085
-
Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression
-
10.1007/s10911-007-9044-6, 17564818
-
Agiostratidou G, Hulit J, Phillips GR, Hazan RB. Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression. J Mammary Gland Biol Neoplasia 2007, 12:127-133. 10.1007/s10911-007-9044-6, 17564818.
-
(2007)
J Mammary Gland Biol Neoplasia
, vol.12
, pp. 127-133
-
-
Agiostratidou, G.1
Hulit, J.2
Phillips, G.R.3
Hazan, R.B.4
-
34
-
-
34548863946
-
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
-
10.1186/gb-2007-8-5-r76, 1929138, 17493263
-
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007, 8:R76. 10.1186/gb-2007-8-5-r76, 1929138, 17493263.
-
(2007)
Genome Biol
, vol.8
-
-
Herschkowitz, J.I.1
Simin, K.2
Weigman, V.J.3
Mikaelian, I.4
Usary, J.5
Hu, Z.6
Rasmussen, K.E.7
Jones, L.P.8
Assefnia, S.9
Chandrasekharan, S.10
Backlund, M.G.11
Yin, Y.12
Khramtsov, A.I.13
Bastein, R.14
Quackenbush, J.15
Glazer, R.I.16
Brown, P.H.17
Green, J.E.18
Kopelovich, L.19
Furth, P.A.20
Palazzo, J.P.21
Olopade, O.I.22
Bernard, P.S.23
Churchill, G.A.24
Van Dyke, T.25
Perou, C.M.26
more..
-
35
-
-
84860896083
-
Pivotal Advance:Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes
-
Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA. Pivotal Advance:Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol 2012,
-
(2012)
J Leukoc Biol
-
-
Van den Bossche, J.1
Lamers, W.H.2
Koehler, E.S.3
Geuns, J.M.4
Alhonen, L.5
Uimari, A.6
Pirnes-Karhu, S.7
Van Overmeire, E.8
Morias, Y.9
Brys, L.10
Vereecke, L.11
De Baetselier, P.12
Van Ginderachter, J.A.13
-
36
-
-
84857395797
-
Interleukin-15 plays a central role in human kidney physiology and cancer through the gammac signaling pathway
-
Giron-Michel J, Azzi S, Khawam K, Mortier E, Caignard A, Devocelle A, Ferrini S, Croce M, Francois H, Lecru L, Charpentier B, Chouaib S, Azzarone B, Eid P. Interleukin-15 plays a central role in human kidney physiology and cancer through the gammac signaling pathway. PLoS One 2015, 7:e31624.
-
(2015)
PLoS One
, vol.7
-
-
Giron-Michel, J.1
Azzi, S.2
Khawam, K.3
Mortier, E.4
Caignard, A.5
Devocelle, A.6
Ferrini, S.7
Croce, M.8
Francois, H.9
Lecru, L.10
Charpentier, B.11
Chouaib, S.12
Azzarone, B.13
Eid, P.14
-
37
-
-
84857147817
-
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
-
10.1371/journal.pone.0030771, 3281867, 22363487
-
Du R, Sun W, Xia L, Zhao A, Yu Y, Zhao L, Wang H, Huang C, Sun S. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 2012, 7:e30771. 10.1371/journal.pone.0030771, 3281867, 22363487.
-
(2012)
PLoS One
, vol.7
-
-
Du, R.1
Sun, W.2
Xia, L.3
Zhao, A.4
Yu, Y.5
Zhao, L.6
Wang, H.7
Huang, C.8
Sun, S.9
-
38
-
-
84859516999
-
Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling
-
10.1074/jbc.M111.258236, 22337876
-
Zhang W, Mendoza MC, Pei X, Ilter D, Mahoney SJ, Zhang Y, Ma D, Blenis J, Wang Y. Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling. J Biol Chem 2012, 287:11850-11858. 10.1074/jbc.M111.258236, 22337876.
-
(2012)
J Biol Chem
, vol.287
, pp. 11850-11858
-
-
Zhang, W.1
Mendoza, M.C.2
Pei, X.3
Ilter, D.4
Mahoney, S.J.5
Zhang, Y.6
Ma, D.7
Blenis, J.8
Wang, Y.9
-
39
-
-
84858019563
-
Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways
-
10.1074/jbc.M111.322800, 22270359
-
Yan D, Avtanski D, Saxena NK, Sharma D. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem 2012, 287:8598-8612. 10.1074/jbc.M111.322800, 22270359.
-
(2012)
J Biol Chem
, vol.287
, pp. 8598-8612
-
-
Yan, D.1
Avtanski, D.2
Saxena, N.K.3
Sharma, D.4
-
40
-
-
74049141478
-
Epigenetics in cancer
-
10.1093/carcin/bgp220, 2802667, 19752007
-
Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis 2010, 31:27-36. 10.1093/carcin/bgp220, 2802667, 19752007.
-
(2010)
Carcinogenesis
, vol.31
, pp. 27-36
-
-
Sharma, S.1
Kelly, T.K.2
Jones, P.A.3
-
41
-
-
51449085561
-
Generation of breast cancer stem cells through epithelial-mesenchymal transition
-
10.1371/journal.pone.0002888, 2492808, 18682804
-
Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008, 3:e2888. 10.1371/journal.pone.0002888, 2492808, 18682804.
-
(2008)
PLoS One
, vol.3
-
-
Morel, A.P.1
Lievre, M.2
Thomas, C.3
Hinkal, G.4
Ansieau, S.5
Puisieux, A.6
-
42
-
-
54049096261
-
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
-
10.1038/onc.2008.207, 2602947, 18591932
-
Korkaya H, Paulson A, Iovino F, Wicha MS. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008, 27:6120-6130. 10.1038/onc.2008.207, 2602947, 18591932.
-
(2008)
Oncogene
, vol.27
, pp. 6120-6130
-
-
Korkaya, H.1
Paulson, A.2
Iovino, F.3
Wicha, M.S.4
-
43
-
-
66249116702
-
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
-
10.1158/0008-5472.CAN-08-4765, 19401449
-
Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM, Sellers WR, Lengauer C, Stegmeier F. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009, 69:4286-4293. 10.1158/0008-5472.CAN-08-4765, 19401449.
-
(2009)
Cancer Res
, vol.69
, pp. 4286-4293
-
-
Wee, S.1
Jagani, Z.2
Xiang, K.X.3
Loo, A.4
Dorsch, M.5
Yao, Y.M.6
Sellers, W.R.7
Lengauer, C.8
Stegmeier, F.9
-
44
-
-
33751346643
-
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
-
10.1186/bcr1610, 1779499, 17062128
-
Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, Goulet R, Badve S, Nakshatri H. CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006, 8:R59. 10.1186/bcr1610, 1779499, 17062128.
-
(2006)
Breast Cancer Res
, vol.8
-
-
Sheridan, C.1
Kishimoto, H.2
Fuchs, R.K.3
Mehrotra, S.4
Bhat-Nakshatri, P.5
Turner, C.H.6
Goulet, R.7
Badve, S.8
Nakshatri, H.9
-
45
-
-
48949119473
-
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
-
10.1186/bcr1982, 2397524, 18366788
-
Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008, 10:R25. 10.1186/bcr1982, 2397524, 18366788.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Fillmore, C.M.1
Kuperwasser, C.2
-
46
-
-
77949900650
-
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
-
10.1182/blood-2009-06-229443, 2826762, 20008787
-
Kharas MG, Okabe R, Ganis JJ, Gozo M, Khandan T, Paktinat M, Gilliland DG, Gritsman K. Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. Blood 2010, 115:1406-1415. 10.1182/blood-2009-06-229443, 2826762, 20008787.
-
(2010)
Blood
, vol.115
, pp. 1406-1415
-
-
Kharas, M.G.1
Okabe, R.2
Ganis, J.J.3
Gozo, M.4
Khandan, T.5
Paktinat, M.6
Gilliland, D.G.7
Gritsman, K.8
-
47
-
-
0035129885
-
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells
-
10.1023/A:1006461422273, 11261825
-
Santner SJ, Dawson PJ, Tait L, Soule HD, Eliason J, Mohamed AN, Wolman SR, Heppner GH, Miller FR. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 2001, 65:101-110. 10.1023/A:1006461422273, 11261825.
-
(2001)
Breast Cancer Res Treat
, vol.65
, pp. 101-110
-
-
Santner, S.J.1
Dawson, P.J.2
Tait, L.3
Soule, H.D.4
Eliason, J.5
Mohamed, A.N.6
Wolman, S.R.7
Heppner, G.H.8
Miller, F.R.9
-
48
-
-
28644435769
-
Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
-
10.1038/sj.bjc.6602862, 2361529, 16288304
-
Lin HJ, Hsieh FC, Song H, Lin J. Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer 2005, 93:1372-1381. 10.1038/sj.bjc.6602862, 2361529, 16288304.
-
(2005)
Br J Cancer
, vol.93
, pp. 1372-1381
-
-
Lin, H.J.1
Hsieh, F.C.2
Song, H.3
Lin, J.4
-
49
-
-
0037229714
-
Overexpression of AKT2/Protein Kinase Bbeta Leads to Up-Regulation of beta1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells
-
Arboleda M, Lyons J, Kabbinavar F, Bray M, Snow B, Ayala R, Danino M, Karlan B, Slamon D. Overexpression of AKT2/Protein Kinase Bbeta Leads to Up-Regulation of beta1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells. Cancer Res 2003, 63:196-206.
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.1
Lyons, J.2
Kabbinavar, F.3
Bray, M.4
Snow, B.5
Ayala, R.6
Danino, M.7
Karlan, B.8
Slamon, D.9
-
50
-
-
77956236877
-
PI(3)king apart PTEN's role in cancer
-
10.1158/1078-0432.CCR-09-2990, 20622047
-
Zhang S, Yu D. PI(3)king apart PTEN's role in cancer. Clin Cancer Res 2010, 16:4325-4330. 10.1158/1078-0432.CCR-09-2990, 20622047.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4325-4330
-
-
Zhang, S.1
Yu, D.2
-
51
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
10.1016/j.ccr.2009.04.012, 2752826, 19573809
-
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 2009, 16:21-32. 10.1016/j.ccr.2009.04.012, 2752826, 19573809.
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
more..
-
52
-
-
70350539589
-
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells
-
10.1158/0008-5472.CAN-09-1067, 2783190, 19843859
-
Vitolo MI, Weiss MB, Szmacinski M, Tahir K, Waldman T, Park BH, Martin SS, Weber DJ, Bachman KE. Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Res 2009, 69:8275-8283. 10.1158/0008-5472.CAN-09-1067, 2783190, 19843859.
-
(2009)
Cancer Res
, vol.69
, pp. 8275-8283
-
-
Vitolo, M.I.1
Weiss, M.B.2
Szmacinski, M.3
Tahir, K.4
Waldman, T.5
Park, B.H.6
Martin, S.S.7
Weber, D.J.8
Bachman, K.E.9
-
53
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
10.1016/j.stem.2007.08.014, 2423808, 18371393
-
Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567. 10.1016/j.stem.2007.08.014, 2423808, 18371393.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
Brown, M.6
Jacquemier, J.7
Viens, P.8
Kleer, C.G.9
Liu, S.10
Schott, A.11
Hayes, D.12
Birnbaum, D.13
Wicha, M.S.14
Dontu, G.15
-
54
-
-
0037948854
-
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
-
10.1101/gad.1061803, 196056, 12756227
-
Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003, 17:1253-1270. 10.1101/gad.1061803, 196056, 12756227.
-
(2003)
Genes Dev
, vol.17
, pp. 1253-1270
-
-
Dontu, G.1
Abdallah, W.M.2
Foley, J.M.3
Jackson, K.W.4
Clarke, M.F.5
Kawamura, M.J.6
Wicha, M.S.7
|