Metabolic impact of 4-hydroxynonenal on macrophage-like RAW 264.7 function and activation

Chemical Research in Toxicology

Volumn 25, Issue 8, 2012, Pages 1643-1651

  Harry, Reese S ^a   Hiatt, Leslie A ^a   Kimmel, Danielle W ^a   Carney, Clare K ^a   Halfpenny, Kristin C ^a   Cliffel, David E ^a   Wright, David W ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; LACTIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ACIDIFICATION; AEROBIC METABOLISM; ANAEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; RESPIRATORY BURST; TISSUE INJURY;

EID: 84865275128     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3001048     Document Type: Article

References (53)

1. Grune, T., Siems, W. G., Schonheit, K., and Blasig, I. E. (1993) Release of 4-hydroxynonenal, an aldehydic mediator of inflammation, during postischaemic reperfusion of the myocardium Int. J. Tissue React. 15, 145-150 (Pubitemid 24060392)
2. Montine, T. J., Huang, D. Y., Valentine, W. M., Amarnath, V., Saunders, A., Weisgraber, K. H., Graham, D. G., and Strittmatter, W. J. (1996) Crosslinking of apolipoprotein E by products of lipid peroxidation J. Neuropathol. Exp. Neurol. 55, 202-210 (Pubitemid 26069298)
3. Sayre, L. M., Zelasko, D. A., Harris, P. L., Perry, G., Salomon, R. G., and Smith, M. A. (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease J. Neurochem. 68, 2092-2097 (Pubitemid 27176147)
4. Selley, M. L. (1998) (E)-4-hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson's disease Free Radical Biol. Med. 25, 169-174 (Pubitemid 28293150)
5. Soares, A. F., Guichardant, M., Cozzone, D., Bernoud-Hubac, N., Bouzaidi-Tiali, N., Lagarde, M., and Geloen, A. (2005) Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes Free Radical Biol. Med. 38, 882-889 (Pubitemid 40321080)
6. Uchida, K., Toyokuni, S., Nishikawa, K., Kawakishi, S., Oda, H., Hiai, H., and Stadtman, E. R. (1994) Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis Biochemistry 33, 12487-12494 (Pubitemid 24340455)
7. Marnett, L. J., Riggins, J. N., and West, J. D. (2003) Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein J. Clin. Invest. 111, 583-593 (Pubitemid 36278574)
8. Hill, B. G., Dranka, B. P., Zou, L., Chatham, J. C., and Darley-Usmar, V. M. (2009) Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal Biochem. J. 424, 99-107
9. Zarkovic, N. (2003) 4-Hydroxynonenal as a bioactive marker of pathophysiological processes Mol. Aspects Med. 24, 281-291 (Pubitemid 36945028)
10. Uchida, K. (2003) 4-Hydroxy-2-nonenal: A product and mediator of oxidative stress Prog. Lipid Res. 42, 318-343 (Pubitemid 36411689)
11. Poli, G. and Schaur, R. J. (2000) 4-Hydroxynonenal in the pathomechanisms of oxidative stress IUBMB Life 50, 315-321 (Pubitemid 32289090)
12. Carney, C. K., Schrimpe, A. C., Halfpenny, K., Harry, R. S., Miller, C. M., Broncel, M., Sewell, S. L., Schaff, J. E., Deol, R., Carter, M. D., and Wright, D. W. (2006) The basis of the immunomodulatory activity of malaria pigment (hemozoin) J. Biol. Inorg. Chem. 11, 917-929 (Pubitemid 44337592)
13. Schwarzer, E., Kuhn, H., Valente, E., and Arese, P. (2003) Malaria-parasitized erythrocytes and hemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions Blood 101, 722-728 (Pubitemid 36077599)
14. Forman, H. J. and Torres, M. (2001) Redox signaling in macrophages Mol. Aspects Med. 22, 189-216 (Pubitemid 33000522)
15. Amatore, C., Arbault, S., Chen, Y., Crozatier, C., and Tapsoba, I. (2007) Electrochemical detection in a microfluidic device of oxidative stress generated by macrophage cells Lab Chip 7, 233-238 (Pubitemid 46238547)
16. Forman, H. J., Dickinson, D. A., and Iles, K. E. (2003) HNE-Signaling pathways leading to its elimination Mol. Aspects Med. 24, 189-194 (Pubitemid 36957831)
17. Vila, A., Tallman, K. A., Jacobs, A. T., Liebler, D. C., Porter, N. A., and Marnett, L. J. (2008) Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives Chem. Res. Toxicol. 21, 432-444
18. Neely, M. D., Amarnath, V., Weitlauf, C., and Montine, T. J. (2002) Synthesis and cellular effects of an intracellularly activated analogue of 4-hydroxynonenal Chem. Res. Toxicol. 15, 40-47 (Pubitemid 34106089)
19. Swindle, E. J., Hunt, J. A., and Coleman, J. W. (2002) A Comparison of Reactive Oxygen Species Generation by Rat Peritoneal Macrophages and Mast Cells Using the Highly Sensitive Real-Time Chemiluminescent Probe Pholasin: Inhibition of Antigen-Induced Mast Cell Degranulation by Macrophage-Derived Hydrogen Peroxide J. Immunol. 169, 5866-5873 (Pubitemid 35291691)
20. Pacheco-Garcia, U., Legorreta-Herrera, M., Hernandez-Rodriguez, C., and Sanchez-Garcia, F. J. (2002) Multiple Mycobacterium microti derived lipids stimulate iNOS gene expression in the J774 murine macrophage cell line Scand. J. Immunol. 56, 52-58 (Pubitemid 35304375)
21. Raines, K. W., Kang, T. J., Hibbs, S., Cao, G.-L., Weaver, J., Tsai, P., Baillie, L., Cross, A. S., and Rosen, G. M. (2006) Importance of Nitric Oxide Synthase in the Control of Infection by Bacillus anthracis Infect. Immun. 74, 2268-2276
22. MacMicking, J., Xie, Q.-W., and Nathan, C. (1997) Nitric Oxide and Macrophage Function Annu. Rev. Immunol. 15, 323-350 (Pubitemid 27169284)
23. Schrimpe, A. C. and Wright, D. W. (2009) Differential gene expression mediated by 15-hydroxyeicosatetraenoic acid in LPS-stimulated RAW 264.7 cells Malar. J. 8, 195
24. Eklund, S. E., Taylor, D., Kozlov, E., Prokop, A., and Cliffel, D. E. (2004) A microphysiometer for simultaneous measurement of changes in extracellular glucose, lactate, oxygen, and acidification rate Anal. Chem. 76, 519-527 (Pubitemid 38166553)
25. Zhang, X., Yin, H., Cooper, J., and Haswell, S. (2008) Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques Anal. Bioanal. Chem. 390, 833-840
26. Hafner, F. (2000) Cytosensor Microphysiometer: Technology and recent applications Biosens. Bioelectron. 15, 149-158 (Pubitemid 30484069)
27. McConnell, H. M., Owicki, J. C., Parce, J. W., Miller, D. L., Baxter, G. T., Wada, H. G., and Pitchford, S. (1992) The cytosensor microphysiometer: Biological applications of silicon technology Science 257, 1906-1912 (Pubitemid 23604212)
28. Wille, K., Paige, L. A., and Higgins, A. J. (2003) Application of the Cytosensor microphysiometer to drug discovery Recept. Channels 9, 125-131 (Pubitemid 36546719)
29. Eklund, S. E., Cliffel, D. E., Kozlov, E., Prokop, A., Wilkswo, J., and Baudenbacher, F. (2003) Modification of the Cytosensor microphysiometer to simultaneously measure extracellular acidification and oxygen consuption rates Anal. Chim. Acta 496, 93-101 (Pubitemid 37352704)
30. Eklund, S. E., Snider, R. M., Wikswo, J., Baudenbacher, F., Prokop, A., and Cliffel, D. E. (2006) Multianalyte microphysiometry as a tool in metabolomics and systems biology J. Electroanal. Chem. 587, 333-339 (Pubitemid 43082886)
31. Eklund, S. E., Thompson, R. G., Snider, R. M., Carney, C. K., Wright, D. W., Wikswo, J., and Cliffel, D. E. (2009) Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer Sensors 9, 2117-2133
32. Zachek, M. K., Park, J., Takmakov, P., Wightman, R. M., and McCarty, G. S. (2010) Microfabricated FSCV-compatible microelectrode array for real-time monitoring of heterogeneous dopamine release Analyst 135, 1556-1563
33. Rhoten, M. C., Burgess, J. D., and Hawkridge, F. M. (2000) Temperature and pH effects on cytochrome c oxidase immobilized in an electrode-supported lipid bilayer membrane Electrochim. Acta 45, 2855-2860
34. Mikkelsen, S. R. and Rechnitz, G. A. (1989) Conductometric tranducers for enzyme-based biosensors Anal. Chem. 61, 1737-1742
35. Lima, E. A., Snider, R. M., Reiser, R. S., McKenzie, J. R., Eklund, S., Cliffel, D. E., and Wikswo, J. P. (2012) Multichamber Multipotentiostat for Cellular Microphysiometry. Rev. Sci. Instrum., manuscript in preparation.
36. Snider, R. M., McKenzie, J. R., Kraft, L., Kozlov, E., Wikswo, J. P., and Cliffel, D. E. (2010) The Effects of Cholera Toxin on Cellular Energy Metabolism Toxins 2, 632-648
37. Köhl, R., Preiss, S., von Knethen, A., and Brüne, B. (2006) Oxidized low-density lipoprotein depletes PKC alpha and attenuates reactive oxygen species formation in monocytes/macrophages Cardiovasc. Res. 71, 574-585 (Pubitemid 44107871)
38. Mosior, M. and Newton, A. C. (1995) Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association J. Biol. Chem. 270, 25526-25533
39. Greene, N. M., Williams, D. S., and Newton, A. C. (1995) Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C J. Biol. Chem. 270, 6710-6717
40. Newton, A. C. (1995) Protein kinase C: Structure, function, and regulation J. Biol. Chem. 270, 28495-28498
41. Schrimpe, A. C. and Wright, D. W. (2009) Comparative Analysis of Gene Expression Changes Mediated by Individual Constituents of Hemozoin Chem. Res. Toxicol. 22, 433-445
42. Borazjani, A., Edelmann, M. J., Hardin, K. L., Herring, K. L., Crow, J. A., and Ross, M. K. (2011) Catabolism of 4-hydroxy-2-trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile Chem.-Biol. Interact. 194, 1-12
43. Yun, M. R., Im, D. S., Lee, S. J., Woo, J. W., Hong, K. W., Bae, S. S., and Kim, C. D. (2008) 4-Hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation Free Radical Biol. Med. 45, 177-183
44. Alary, J., Gueraud, F., and Cravedi, J.-P. (2003) Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways Mol. Aspects Med. 24, 177-187 (Pubitemid 36945018)
45. Ji, C., Kozak, K. R., and Marnett, L. J. (2001) IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal J. Biol. Chem. 276, 18223-18228
46. Luckey, S. W., Taylor, M., Sampey, B. P., Scheinman, R. I., and Petersen, D. R. (2002) 4-Hydroxynonenal Decreases Interleukin-6 Expression and Protein Production in Primary Rat Kupffer Cells by Inhibiting Nuclear Factor-ΰB Activation J. Pharmacol. Exp. Ther. 302, 296-303 (Pubitemid 34680451)
47. Schopfer, F. J., Cipollina, C., and Freeman, B. A. (2011) Formation and Signaling Actions of Electrophilic Lipids Chem. Rev. 111, 5997-6021
48. Dianzani, C., Parrini, M., Ferrara, C., and Fantozzi, R. (1996) Effect of 4-hydroxynonenal on superoxide anion production from primed human neutrophils Cell Biochem. Funct. 14, 193-200 (Pubitemid 26341204)
49. Schwarzer, E. and Arese, P. (1996) Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages Biochim. Biophys. Acta 1316, 169-175 (Pubitemid 26273701)
50. Fritz, K. S. and Petersen, D. R. (2011) Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation Chem. Res. Toxicol. 24, 1411-1419
51. Majumder, N., Bhattacharjee, S., Bhattacharyya, S., Dey, R., Guha, P., Pal, N. K., and Majumdar, S. (2008) Restoration of impaired free radical generation and proinflammatory cytokines by MCP-1 in mycobacterial pathogenesis Scand. J. Immunol. 67, 329-339 (Pubitemid 351392919)
52. Dubinina, E. E. and Dadali, V. A. (2010) Role of 4-Hydroxy-trans-2- nonenal in Cell Functions Biochemistry (Moscow) 75, 1069-1087
53. Li, L., Hamilton, R. F., Jr., Kirichenko, A., and Holian, A. (1996) 4-Hydroxynonenal-induced cell death in murine alveolar macrophages Toxicol. Appl. Pharmacol. 139, 135-143 (Pubitemid 26247071)