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Volumn 23, Issue 15, 2012, Pages 2195-2200

Enantioselective organocatalytic thiol addition to α,β- unsaturated α-amino acid derivatives

Author keywords

amino acids; cinchona alkaloids; conjugate addition; organocatalysis; thiols

Indexed keywords

ALPHA,BETA UNSATURATED AMINO ACID DERIVATIVE; AMINO ACID DERIVATIVE; LACTONE DERIVATIVE; PSEUDOAZLACTONE DERIVATIVE; THIOL DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84865270048     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0032-1317081     Document Type: Article
Times cited : (18)

References (31)
  • 28
    • 84866088024 scopus 로고    scopus 로고
    • Crystal Structure Data for Compound 12: M w =482.27; colorless platelet; 0.27×0.22×0.06mm; orthorhombic; P 2 1 2 1 2 1 ; a =10.0062(7)Å, b =11.8687(4)Å, c =18.6029(12)Å; V =2209.3(2)Å 3 ; Z =4; D =1.451g·cm -3 ; μ =0.209mm -1 . 66682 reflections were measured with a Nonius KappaCCD diffractometer (Mo radiation, graphite monochromator, λ=0.71073Å) up to a resolution of sin θ / λ =0.65 Å -1 at 208K. 5067 reflections were unique (R int =0.0423) of which 4371 were observed with I o 2σ(I o ). The structure was solved by direct methods with the PATTY option of the DIRDIF program system 23b,c and refined against F 2 using SHELXL. 23d All non-hydrogen atoms were refined with anisotropic temperature factors. The hydrogen atoms were placed at calculated positions and refined isotropically in riding mode. The three fluorine atoms could not be refined adequately because of rotational disorder. The absolute structure was determined based on the anomalous dispersion of 2199 Friedel pairs, Flack parameter=0.00(12), the Hooft parameter y=0.014(16). R 1 =0.0685 [I 2σ(I)]; R 1 =0.0806 [all reflections]; S=1.537. Residual electron density between 1.334 and -0.562e·Å -3 . The data were deposited with the Cambridge Crystallographic Data Centre (CCDC 882528). More detailed information can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/cif
  • 31
    • 0004150157 scopus 로고    scopus 로고
    • University of Göttingen Germany
    • Sheldrick GM. SHELXL-97. University of Göttingen Germany: 1997
    • (1997) SHELXL-97
    • Sheldrick, G.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.