A randomized open-label trial on the use of budesonide/formoterol (Symbicort® ) as an alternative reliever medication for mild to moderate asthmatic attacks

International Journal of Emergency Medicine

Volumn 5, Issue 1, 2012, Pages

  Chew, Keng Sheng ^a   Kamarudin, Hamizah ^a   Hashim, Che Wan ^b  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b Respiratory and Medical Clinic   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; BUDESONIDE PLUS FORMOTEROL; FORMOTEROL; SALBUTAMOL;

5 POINT LIKERT SCALE; ADULT; ARTICLE; ASTHMA; BREATHING RATE; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; EMERGENCY WARD; FEMALE; HUMAN; MALE; NEBULIZATION; OPEN STUDY; OXYGEN SATURATION; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SYMPTOM; TREATMENT OUTCOME; TREATMENT RESPONSE; VISUAL ANALOG SCALE; WILCOXON SIGNED RANKS TEST;

EID: 84865239292     PISSN: 18651372     EISSN: 18651380     Source Type: Journal    
DOI: 10.1186/1865-1380-5-16     Document Type: Article

References (17)

1. GINA: Global strategy for asthma management and prevention (updated 2010). 2010 http://www.ginasthma.org, Accessed on 4 November 2011.
2. Varia M, Wilson S, Sarwal S, McGeer A, Gournis E, Galanis E, Henry B: Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ 2003, 169(4):285-292. (Pubitemid 37047056)
3. Cates CJ, Crilly JA, Rowe BH: Holding chambers (spacers) versus nebulisers for betaagonist treatment of acute asthma. Cochrane Database Syst Rev 2006, 2: CD000052.
4. Newman SP: Therapeutic inhalation agents and devices. Effectiveness in asthma and bronchitis. Postgrad Med 1984, 76(5):194-203-206-207.
5. Weber EJ, Silverman RA, Callaham ML, Pollack CV, Woodruff PG, Clark S, Camargo CA Jr: A prospective multicenter study of factors associated with hospital admission among adults with acute asthma. Am J Med 2002, 113(5):371-378. (Pubitemid 35223608)
6. Palmqvist M, Ibsen T, Mellen A, Lotvall J: Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am J Respir Crit Care Med 1999, 160(1):244-249. (Pubitemid 29326095)
7. Boonsawat W, Charoenratanakul S, Pothirat C, Sawanyawisuth K, Seearamroongruang T, Bengtsson T, Brander R, Selroos O: Formoterol (OXIS) Turbuhaler as a rescue therapy compared with salbutamol pMDI plus spacer in patients with acute severe asthma. Respir Med 2003, 97(9):1067-1074. (Pubitemid 37098773)
8. Bateman ED, Fairall L, Lombardi DM, English R: Budesonide/formoterol and formoterol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol. Respir Res 2006, 7:13.
9. Barnes PJ: Scientific rationale for using a single inhaler for asthma control. Eur Respir J 2007, 29(3):587-595. (Pubitemid 46372109)
10. Aziz I, Lipworth BJ: A bolus of inhaled budesonide rapidly reverses airway subsensitivity and beta2-adrenoceptor down-regulation after regular inhaled formoterol. Chest 1999, 115(3):623-628. (Pubitemid 29129935)
11. O'Byrne PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekstrom T, Bateman ED: Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005, 171(2):129-136. (Pubitemid 40105411)
12. Karras DJ, Sammon ME, Terregino CA, Lopez BL, Griswold SK, Arnold GK: Clinically meaningful changes in quantitative measures of asthma severity. Acad Emerg Med 2000, 7(4):327-334. (Pubitemid 30207971)
13. Saghaei M: Random Allocation Software. Randomization http:// mahmoodsaghaei.tripod.com/Softwares/randalloc.html#Version, Accessed: March 9, 2010.
14. Balanag VM, Yunus F, Yang PC, Jorup C: Efficacy and safety of budesonide/formoterol compared with salbutamol in the treatment of acute asthma. Pulm Pharmacol Ther 2006, 19(2):139-147. (Pubitemid 43053002)
15. Haughney J, Barnes G, Partridge M, Cleland J: The Living & Breathing Study: a study of patients' views of asthma and its treatment. Prim Care Respir J 2004, 13(1):28-35. (Pubitemid 38248440)
16. FitzGerald JM, Boulet LP, McIvor RA, Zimmerman S, Chapman KR: Asthma control in Canada remains suboptimal: the Reality of Asthma Control (TRAC) study. Can Respir J 2006, 13(5):253-259. (Pubitemid 44489837)
17. Kaplan A, Ryan D: The role of budesonide/formoterol for maintenance and relief in the management of asthma. Pulm Pharmacol Ther 2010, 23(2):88-96.