Determinants and prognostic significance of exercise pulmonary hypertension in asymptomatic severe aortic stenosis

Circulation

Volumn 126, Issue 7, 2012, Pages 851-859

  Lancellotti, Patrizio ^a   Magne, Julien ^a   Donal, Erwan ^b   O'Connor, Kim ^a   Dulgheru, Raluca ^a   Rosca, Monica ^a   Pierard, Luc A ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

aortic valve stenosis; echocardiography; exercise; heart valves; hypertension, pulmonary

Indexed keywords

AGED; AORTA PRESSURE; AORTA STENOSIS; ARTICLE; DISEASE ASSOCIATION; DISEASE SEVERITY; EVENT FREE SURVIVAL; EXERCISE PULMONARY HYPERTENSION; EXERCISE STRESS ECHOCARDIOGRAPHY; FEMALE; HUMAN; LUNG ARTERY PRESSURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY HYPERTENSION; SEX DIFFERENCE; STRESS ECHOCARDIOGRAPHY; SYSTOLIC PULMONARY ARTERIAL PRESSURE; VELOCITY;

AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; ARTERIAL PRESSURE; ECHOCARDIOGRAPHY, STRESS; EXERCISE TEST; FEMALE; HEART VENTRICLES; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; PROGNOSIS; PULMONARY WEDGE PRESSURE; SEVERITY OF ILLNESS INDEX; SEX FACTORS; STROKE VOLUME;

EID: 84865219182     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.088427     Document Type: Article

References (33)

1. Herrmann S, Stork S, Niemann M, Lange V, Strotmann JM, Frantz S, Beer M, Gattenlohner S, Voelker W, Ertl G, Weidemann F. Low-gradient aortic valve stenosis myocardial fibrosis and its influence on function and outcome. J Am Coll Cardiol. 2011;58:402-412.
2. Weidemann F, Herrmann S, Stork S, Niemann M, Frantz S, Lange V, Beer M, Gattenlohner S, Voelker W, Ertl G, Strotmann JM. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation. 2009;120:577-584.
3. Kang DH, Park SJ, Rim JH, Yun SC, Kim DH, Song JM, Choo SJ, Park SW, Song JK, Lee JW, Park PW. Early surgery versus conventional treatment in asymptomatic very severe aortic stenosis. Circulation. 2010; 1502-1509.
4. Monin JL, Lancellotti P, Monchi M, Lim P, Weiss E, Pierard LA, Gueret P. Risk score for predicting outcome in patients with asymptomatic aortic stenosis. Circulation. 2009;120:69-75.
5. Lancellotti P, Donal E, Magne J, Moonen M, O'Connor K, Daubert JC, Pierard LA. Risk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay. Heart. 2010;96:1364-1371.
6. Cooper R, Ghali J, Simmons BE, Castaner A. Elevated pulmonary artery pressure: an independent predictor of mortality. Chest. 1991;99:112-120.
7. McHenry MM, Rice J, Matlof HJ, Flamm MD Jr. Pulmonary hypertension and sudden death in aortic stenosis. Br Heart J. 1979;41: 463-467. (Pubitemid 9180371)
8. Copeland JG, Griepp RB, Stinson EB, Shumway NE. Long-term follow-up after isolated aortic valve replacement. J Thorac Cardiovasc Surg. 1977;74:875-889. (Pubitemid 8236939)
9. Carnero-Alcazar M, Reguillo-Lacruz F, Alswies A, Villagran-Medinilla E, Maroto-Castellanos LC, Rodriguez-Hernandez J. Short-and mid-term results for aortic valve replacement in octogenarians. Interact Cardiovasc Thorac Surg. 2010;10:549-554.
10. Rodes-Cabau J, Webb JG, Cheung A, Ye J, Dumont E, Feindel CM, Osten M, Natarajan MK, Velianou JL, Martucci G, DeVarennes B, Chisholm R, Peterson MD, Lichtenstein SV, Nietlispach F, Doyle D, DeLarochelliere R, Teoh K, Chu V, Dancea A, Lachapelle K, Cheema A, Latter D, Horlick E. Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience. J Am Coll Cardiol. 2010;55:1080-1090.
11. Lancellotti P, Moonen M, Magne J, O'Connor K, Cosyns B, Attena E, Donal E, Pierard L. Prognostic effect of long-axis left ventricular dysfunction and B-type natriuretic peptide levels in asymptomatic aortic stenosis. Am J Cardiol. 2010;105:383-388.
12. Schwammenthal E, Vered Z, Agranat O, Kaplinsky E, Rabinowitz B, Feinberg MS. Impact of atrioventricular compliance on pulmonary artery pressure in mitral stenosis: an exercise echocardiographic study. Circulation. 2000;102:2378-2384.
13. Magne J, Lancellotti P, Pierard LA. Exercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation. Circulation. 2010;122: 33-41.
14. Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Page RL, Riegel B. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of patients With Valvular Heart Disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2006;48:e1-148.
15. Vahanian A, Baumgartner H, Bax J, Butchart E, Dion R, Filippatos G, Flachskampf F, Hall R, Iung B, Kasprzak J, Nataf P, Tornos P, Torracca L, Wenink A, Priori SG, Blanc JJ, Budaj A, Camm J, Dean V, Deckers J, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo J, Zamorano JL, Zamorano JL, Angelini A, Antunes M, Fernandez MA, Gohlke-Baerwolf C, Habib G, McMurray J, Otto C, Pierard L, Pomar JL, Prendergast B, Rosenhek R, Uva MS, Tamargo J. Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J. 2007;28:230-268. (Pubitemid 46276943)
16. Buonanno C, Johnson LW, Bowser MA, Hapanowicz MB, Marvasti M, Parker FB. Pulmonary hypertension in severe aortic stenosis: incidence, mechanisms, clinical and surgical implications. G Ital Cardiol. 1987;17: 636-641.
17. Johnson LW, Hapanowicz MB, Buonanno C, Bowser MA, Marvasti MA, Parker FB Jr. Pulmonary hypertension in isolated aortic stenosis: hemo-dynamic correlations and follow-up. J Thorac Cardiovasc Surg. 1988; 95:603-607. (Pubitemid 18098524)
18. Silver K, Aurigemma G, Krendel S, Barry N, Ockene I, Alpert J. Pulmonary artery hypertension in severe aortic stenosis: incidence and mechanism. Am Heart J. 1993;125:146-150. (Pubitemid 23021636)
19. Kapoor N, Varadarajan P, Pai RG. Echocardiographic predictors of pulmonary hypertension in patients with severe aortic stenosis. Eur J Echocardiogr. 2008;9:31-33. (Pubitemid 351664800)
20. Casaclang-Verzosa G, Nkomo VT, Sarano ME, Malouf JF, Miller FA Jr, Oh JK. E/Ea is the major determinant of pulmonary artery pressure in moderate to severe aortic stenosis. J Am Soc Echocardiogr. 2008;21: 824-827.
21. O'Connor K, Magne J, Rosca M, Pierard LA, Lancellotti P. Impact of aortic valve stenosis on left atrial phasic function. Am J Cardiol. 2010; 106:1157-1162.
22. O'Connor K, Magne J, Rosca M, Pierard LA, Lancellotti P. Left atrial function and remodelling in aortic stenosis. Eur J Echocardiogr. 2011; 12:299-305.
23. Saraiva RM, Yamano T, Matsumura Y, Takasaki K, Toyono M, Agler DA, Greenberg N, Thomas JD, Shiota T. Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation. Am Heart J. 2009;158: 309-316.
24. Malouf J, Enriquez-Sarano M, Pellikka P, Oh J, Bailey K, Chandrasekaran K, Mullany C, Tajik A. Severe pulmonary hypertension in patients with severe aortic valve stenosis: clinical profile and prognostic implications. J Am Coll Cardiol. 2002;40:789.
25. Cam A, Goel SS, Agarwal S, Menon V, Svensson LG, Tuzcu EM, Kapadia SR. Prognostic implications of pulmonary hypertension in patients with severe aortic stenosis. J Thorac Cardiovasc Surg. 2011;142: 800-808.
26. Tracy GP, Proctor MS, Hizny CS. Reversibility of pulmonary artery hypertension in aortic stenosis after aortic valve replacement. Ann Thorac Surg. 1990;50:89-93. (Pubitemid 20220608)
27. Pai RG, Varadarajan P, Kapoor N, Bansal RC. Aortic valve replacement improves survival in severe aortic stenosis associated with severe pulmonary hypertension. Ann Thorac Surg. 2007;84:80-85. (Pubitemid 46921129)
28. Lancellotti P, Lebois F, Simon M, Tombeux C, Chauvel C, Pierard LA. Prognostic importance of quantitative exercise Doppler echocardiography in asymptomatic valvular aortic stenosis. Circulation. 2005;112(suppl): I-377-I-382. (Pubitemid 41266702)
29. Marechaux S, Hachicha Z, Bellouin A, Dumesnil JG, Meimoun P, Pasquet A, Bergeron S, Arsenault M, Le Tourneau T, Ennezat PV, Pibarot P. Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis. Eur Heart J. 2010; 31:1390-1397.
30. Mahjoub H, Levy F, Cassol M, Meimoun P, Peltier M, Rusinaru D, Tribouilloy C. Effects of age on pulmonary artery systolic pressure at rest and during exercise in normal adults. Eur J Echocardiogr. 2009;10: 635-640.
31. Magne J, Lancellotti P, Pierard LA. Exercise-induced changes in degenerative mitral regurgitation. J Am Coll Cardiol. 2010;56:300-309.
32. Kovacs G, Maier R, Aberer E, Brodmann M, Scheidl S, Hesse C, Troester N, Salmhofer W, Stauber R, Fuerst FC, Thonhofer R, Ofner-Kopeinig P, Gruenig E, Olschewski H. Assessment of pulmonary arterial pressure during exercise in collagen vascular disease: echocardiography vs right-sided heart catheterization. Chest. 2010;138:270-278.
33. Tumminello G, Lancellotti P, Lempereur M, D'Orio V, Pierard LA. Determinants of pulmonary artery hypertension at rest and during exercise in patients with heart failure. Eur Heart J. 2007;28:569-574. (Pubitemid 47355524)