Pulmonary epithelial apoptosis in fetal down syndrome: Not higher than normal

Pediatric and Developmental Pathology

Volumn 15, Issue 3, 2012, Pages 199-205

  Bruijn, Martijn ^a   Von Der Thüsen, Jan H ^b   Van Der Loos, Chris M ^a   De Krijger, Ronald R ^c   Van Loenhout, Rhiannon B ^d   Bos, Albert P ^a   Van Woensel, Job B M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MEDICAL CENTER HAAGLANDEN   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Apoptosis; Caspase 3; Fetal development; Respiratory mucosa; Trisomy 21

Indexed keywords

CASPASE 3; CYTOKERATIN;

ACUTE LUNG INJURY; APOPTOSIS; ARTICLE; AUTOPSY; CELL COUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN SYNDROME; FETUS; GESTATIONAL AGE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG PARENCHYMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ACUTE LUNG INJURY; APOPTOSIS; AUTOPSY; CASPASE 3; DOWN SYNDROME; EPITHELIAL CELLS; FETUS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LUNG;

EID: 84865211783     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/11-08-1080-OA.1     Document Type: Article

References (24)

1. Roizen NJ, Patterson D. Down's syndrome. Lancet 2003;361:1281-1289. (Pubitemid 36428586)
2. McDowell KM, Craven DI. Pulmonary complications of Down syndrome during childhood. J Pediatr 2011;158:319-325.
3. Sawa A. Neuronal cell death in Down's syndrome. J Neural Transm Suppl 1999;57:87-97.
4. Yasui K, Shinozaki K, Nakazawa T, Agematsu K, Komiyama A. Presenility of granulocytes in Down syndrome individuals. Am J Med Genet 1999;84:406-412. (Pubitemid 29239281)
5. Bruijn M, van der Aa LB, van Rijn RR, Bos AP, van Woensel JB. High incidence of acute lung injury in children with Down syndrome. Intensive Care Med 2007;33:2179-2182. (Pubitemid 350164553)
6. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349. (Pubitemid 30408719)
7. Matute-Bello G, Martin TR. Science review: apoptosis in acute lung injury. Crit Care 2003;7:355-358. (Pubitemid 37236306)
8. Scavo LM, Ertsey R, Chapin CJ, Allen L, Kitterman JA. Apoptosis in the development of rat and human fetal lungs. Am J Respir Cell Mol Biol 1998;18:21-31. (Pubitemid 128355343)
9. Bustani P, Hodge R, Tellabati A, Li J, Pandya H, Kotecha S. Differential response of the epithelium and interstitium in developing human fetal lung explants to hyperoxia. Pediatr Res 2006;59:383-388. (Pubitemid 43740075)
10. Wongtrakool C, Roman J. Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis. Exp Lung Res 2008;34:481-499.
11. Cooney TP, Thurlbeck WM. Pulmonary hypoplasia in Down's syndrome. N Engl J Med 1982;307:1170-1173. (Pubitemid 12037976)
12. Cooney TP, Wentworth PJ, Thurlbeck WM. Diminished radial count is found only postnatally in Down's syndrome. Pediatr Pulmonol 1988;5:204-209.
13. Schloo BL, Vawter GF, Reid LM. Down syndrome: patterns of disturbed lung growth. Hum Pathol 1991;22:919-923.
14. Dutch Federation of Biomedical Scientific Societies. Code for Proper Secondary Use of Human Tissue in The Netherlands, version 2002. Available at http://www.federa.org/downloads. Accessed July 3, 2011.
15. Galani V, Tatsaki E, Bai M, et al. The role of apoptosis in the pathophysiology of acute respiratory distress syndrome (ARDS): an up-to-date cell-specific review. Pathol Res Pract 2010;206:145-150.
16. Galluzzi L, Aaronson SA, Abrams J, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 2009;16:1093-1107.
17. van der Loos CM. Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem 2008;56:313-328.
18. Del Riccio V, van Tuyl M, Post M. Apoptosis in lung development and neonatal lung injury. Pediatr Res 2004;55:183-189. (Pubitemid 38120993)
19. Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995;378:776-779. (Pubitemid 26004408)
20. Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G. Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kappaB in brains of patients with Down syndrome. J Neural Transm Suppl 2001;(61):181-192. (Pubitemid 38085081)
21. Engidawork E, Balic N, Juranville JF, Fountoulakis M, Dierssen M, Lubec G. Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis. J Neural Transm Suppl 2001;(61):149-162. (Pubitemid 38085079)
22. Gulesserian T, Engidawork E, Yoo BC, Cairns N, Lubec G. Alteration of caspases and other apoptosis regulatory proteins in Down syndrome. J Neural Transm Suppl 2001;(61):163-179. (Pubitemid 38085080)
23. Thorpe-Beeston JG, Nicolaides KH, Gosden CM, McGregor AM. Thyroid function in fetuses with chromosomal abnormalities. BMJ 1991;302:628.
24. Olson LE, Richtsmeier JT, Leszl J, Reeves RH. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science 2004;306:687-690. (Pubitemid 39440917)