ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

EMBO Journal

Volumn 31, Issue 16, 2012, Pages 3398-3410

  Thanasoula, Maria ^a,b   Escandell, Jose Miguel ^a   Suwaki, Natsuko ^a   Tarsounas, Madalena ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

ATM ATR kinases; CDC25 phosphatases; checkpoint activation; telomere

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PROTEASOME; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE A; PROTEIN TYROSINE PHOSPHATASE B; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; NUCLEAR EXPORT SIGNAL; POT1 GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TELOMERE; TRANSCRIPTION REGULATION;

CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; CELL LINE; CYTOKINESIS; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; TELOMERE; TUMOR SUPPRESSOR PROTEINS;

EID: 84865210853     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.191     Document Type: Article

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