Handling a tricycle: Orthogonal versus random oxidation of the tricyclic inhibitor cystine knotted peptide gurmarin

Peptides

Volumn 37, Issue 1, 2012, Pages 144-149

  Eliasen, Rasmus ^a,b   Andresen, Thomas L ^b   Conde Frieboes, Kilian W ^a  

^a NOVO NORDISK A S   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Disulfide formation; Gurmarin; Inhibitor cystine knot; Orthogonal oxidation; Peptide synthesis

Indexed keywords

CYSTAMINE; CYSTEINE; CYSTINE; DISULFIDE; GLUTATHIONE; GURMARIN; HYDROCHLORIC ACID; PLANT EXTRACT; THERMOLYSIN; TRICYCLIC AROMATIC COMPOUND; TRITYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG SYNTHESIS; GYMNEMA SYLVESTRE; ORTHOGONAL OXIDATION; OXIDATION; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; CYSTINE KNOT MOTIFS; MERCAPTOETHANOL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OXIDANTS; OXIDATION-REDUCTION; PLANT PROTEINS; PROTEOLYSIS; SILANES; TASTE; THERMOLYSIN; TRIFLUOROACETIC ACID;

GYMNEMA SYLVESTRE; RODENTIA;

EID: 84865210379     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.06.016     Document Type: Article

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