How genetic variant libraries effectively extend gene testing patents: Implications for intellectual property and good clinical care

Journal of Clinical Oncology

Volumn 30, Issue 24, 2012, Pages 2943-2945

  McElligott, Sean ^a   Field, Robert I ^b   Bristol Demeter, Mirar ^a   Domchek, Susan M ^c   Asch, David A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE MUTATION; GENETIC LINKAGE; GENETIC SCREENING; GENETIC VARIABILITY; NOTE; ONCOGENE; PATENT; PRIORITY JOURNAL;

GENE LIBRARY; GENETIC TESTING; GENETIC VARIATION; HUMANS; INTELLECTUAL PROPERTY; PATENTS AS TOPIC;

EID: 84865196668     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.42.7757     Document Type: Note

References (11)

1. Domchek SM, Friebel TM, Singer CF, et al: Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 304:967-975, 2010
2. Spearman AD, Sweet K, Zhou XP, et al: Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol 26:5393-5400, 2008
3. Thompson D, Easton DF, Goldgar DE: A full-likelihood method for the evaluation of causality of sequence variants from family data. Am J Hum Genet 73:652-655, 2003 (Pubitemid 37076278)
4. Lindor NM, Guidugli L, Wang X, et al: A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS). Hum Mutat 33:8-21, 2012
5. Samuels ME, Rouleau GA: The case for locus-specific databases. Nat Rev Genet 12:378-379, 2011
6. Pollack A: Despite gene patent victory, Myriad Genetics faces challenges. http://www.nytimes.com/2011/08/25/business/despite-gene-patent-victory-myriad- genetics-faces-challenges.html
7. Association for Molecular Technology v US Patent and Trademark Office. 653 F 3d 1329 Fed Cir, 2011
8. Phimister EG, Feero WG, Guttmacher AE: Realizing genomic medicine. N Engl J Med 366:757-759, 2012
9. Szabo C, Masiello A, Ryan JF, et al: The breast cancer information core: Database design, structure, and scope. Hum Mutat 16:123-131, 2000 (Pubitemid 30604901)
10. Spurdle AB, Healey S, Devereau A, et al: ENIGMA: Evidence-based network for the interpretation of germline mutant alleles - An international initiative to evaluate risk and clinical significance associated with sequence variation in BRCA1 and BRCA2 genes. Hum Mutat 33:2-7, 2012
11. Fokkema IF, den Dunnen JT, Taschner PE: LOVD: Easy creation of a locus-specific sequence variation database using an "LSDB-in-a-box" approach. Hum Mutat 26:63-68, 2005 (Pubitemid 41040673)