Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

Retrovirology

Volumn 9, Issue , 2012, Pages

  van Rompay, Koen K A ^a   Trott, Kristin A ^a   Jayashankar, Kartika ^a   Geng, Yongzhi ^a   LaBranche, Celia C ^b   Johnson, Jeffrey A ^c   Landucci, Gary ^d   Lipscomb, Jonathan ^c   Tarara, Ross P ^a   Canfield, Don R ^a   Heneine, Walid ^c   Forthal, Donald N ^d   Montefiori, David ^b   Abel, Kristina ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GENERAL ELECTRIC COMPANY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Antiretroviral; Functional cure; HIV; PMPA; SIV; Tenofovir

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TENOFOVIR;

ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BLOOD LEVEL; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; FOLLOW UP; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MACACA MULATTA; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; TISSUE LEVEL; TREATMENT DURATION; VIREMIA; VIRUS CELL INTERACTION; VIRUS IMMUNITY; VIRUS MUTANT; VIRUS REPLICATION; VIRUS TITRATION; WILD TYPE;

ADENINE; ALLELES; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GENES, MHC CLASS I; GENOTYPING TECHNIQUES; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; MACACA MULATTA; NEUTRALIZATION TESTS; ORGANOPHOSPHONATES; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TIME FACTORS; TREATMENT OUTCOME; VIREMIA; VIRUS REPLICATION;

EID: 84865180390     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-9-57     Document Type: Article

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