Protein interactions in 3D: From interface evolution to drug discovery

Journal of Structural Biology

Volumn 179, Issue 3, 2012, Pages 347-358

  Winter, Christof ^a   Henschel, Andreas ^b   Tuukkanen, Anne ^a   Schroeder, Michael ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b KHALIFA UNIVERSITY   (United Arab Emirates)

Author keywords

Databases; Drug repositioning; Evolution; Protein interaction prediction; Structural protein interaction

Indexed keywords

HETERODIMER; HOMODIMER;

ACCURACY; BINDING AFFINITY; BINDING SITE; CONVERGENT EVOLUTION; DRUG TARGETING; EVOLUTIONARY ALGORITHM; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DATABASE; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TARGETING; REVIEW; SEQUENCE HOMOLOGY; STATIC ELECTRICITY; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING;

ALGORITHMS; COMPUTER SIMULATION; DATABASES, PROTEIN; DRUG DISCOVERY; EVOLUTION, MOLECULAR; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 84865168586     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2012.04.009     Document Type: Review

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