Improved biopharmaceutical performance and antifungal efficacy of mucoadhesive films with nystatin

Pharma Research

Volumn 5, Issue 2, 2011, Pages 193-205

  Llabot, Juan M ^a   Sanchez, Natalia V ^a   Palma, Santiago D ^a   Manzo, Ruben H ^a   Allemandi, Daniel A ^a   Alovero, Fabiana L ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Bioadhesive films; Bioassay; Candida albicans; Carbomer 974; Nystatin; Poloxamer 407

Indexed keywords

CARBOMER; CARBOXYMETHYLCELLULOSE; NYSTATIN; POLOXAMER; SURFACTANT;

AGAR DIFFUSION; ANTIFUNGAL ACTIVITY; ARTICLE; BIOASSAY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG ANALYSIS; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG POTENCY; FILM COATING; HYDROPHILICITY; IN VITRO STUDY; MUCOADHESION; MUCOADHESIVE FILM; NONHUMAN; SWELLING; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TIMED DRUG RELEASE;

EID: 84865160518     PISSN: None     EISSN: 09758216     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Aguirre Urizar JM. Candidiasis orales. Rev Iberoam Micol 2002, 19, 17-21.
2. Goodman Gilman A, Haidman J G, Molinoff P B, Rudolon F W. Goodman & Gillman, Las bases farmacológicas de la terapéutica. Tenth edition. México D.F., The McGraw-Hill Interamericana editores, S A, 2003, 21-22.
3. Croy SR and Kwon G S. The effects of Pluronic block copolymers on the aggregation state of nystatin. J Control Release 2004, 95, 161-171.
4. Kim T H , Ahn J S, Choi H K, Choi Y J, Cho Ch S. A Novel Mucoadhesive Polymer Film Composed of Carbopol, Poloxamer and Hydroxypropylmethylcellulose. Arch Pharm Res 2007, 30, 381-386.
5. Llabot J M, Palma S D, Manzo R H, Allemandi D A. Design of novel antifungal mucoadhesive films, Part I. Pre-formulation studies. Int J Pharm 2007, 330, 54-60.
6. Llabot J M, Palma S D, Manzo R H, Allemandi D A. Design of novel antifungal mucoadhesive films, Part II. Formulation and in vitro biopharmaceutical evaluation- Int J Pharm 2007, 336, 263-268.
7. Chun M K, Cho C S, Choi H K. Novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poloxamer. J Appl Polymer Sci 2001, 79, 1525-1530.
8. Spadaro A C, Leitao D P, Polizello A C M, Pedrazzi V, Mestriner Jr. W. Construction and evaluation of an inexpensive device that simulates oral clearance. Braz Dent J 2001, 12, 183-186.
9. Farmacopea Nacional Argentina, 2003, 7th ed., Vol. 1. Ministerio de Salud, Buenos Aires, Argentina.
10. Rowe R, Sheskey P, Owen S (eds). Handbook of Pharmaceutical Excipients, 5th ed. London, Pharmaceutical Press, 2006, 535-538.
11. Chun M K, Cho C S, Choi H K. Novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poloxamer. J Appl Polymer Sci 2001, 79, 1525-1530.
12. Cole M L, Whateley T L. Interaction of Nonionic Block Copolymeric (Poloxamer) Surfactants with Poly (Acrylic Acid), Studied by Photon Correlation Spectroscopy. J Colloid Interf Sci 1996, 180, 421-427.
13. Palma S D, Manzo R H, Lo Nostro P, Allemandi D A. Nanostructures form alkyl Vitamin C derivatives (ASCn), properties and potential platform for drug delivery. Int J Pharm 2007, 345, 26-34.
14. Sokol-Anderson M, Brajtburg J, Medoff G. Anmphotericin B induced oxidative damage and killing of Candida albicans. J Infect Dis 1986, 154, 76-83.
15. Okamoto Y, Aoki S, Mataga I. Enhancement of amphotericin B activity against Candida albicans by superoxide radical. Mycopathologia 2004, 158, 9-15.
16. MaoMao A, Hui S, Yong Bing C, JunDong Z, Yun C, Rui W, YuanYing J. Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans. Int J Antimicrob Agents 2009, 33, 258-263.