Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5545-5549

  Kim, Heung Jae ^a,b   Kwak, Woo Young ^a   Min, Jong Pil ^a   Sung, Si Young ^a   Kim, Ha Dong ^a   Kim, Mi Kyung ^a   Kim, Hae Sun ^a   Park, Kyung Jin ^a   Son, Moon Ho ^a   Kim, Soon Hoe ^a   Lee, Bong Jin ^b  

^a Dong A Pharmaceutical Company   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Amino amide; Diabetes; DPP4; GLP 1

Indexed keywords

BETA AMINO ACID; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PIPERAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOGS; GLUCOSE TOLERANCE TEST; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84865143541     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.019     Document Type: Article

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