The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity

Molecular Biology Reports

Volumn 39, Issue 9, 2012, Pages 9193-9201

  You, Chuangang ^a   Han, Chunmao ^a   Wang, Xingang ^a   Zheng, Yurong ^a   Li, Qiyin ^a   Hu, Xinlei ^a   Sun, Huafeng ^a,b  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b The 117th Hospital of Chinese PLA   (China)

Author keywords

Application; Mechanism; Silver nanoparticles

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MOLECULAR SCAFFOLD; NANOCRYSTALLINE SILVER; OXYGEN; POLY (3 HYDROXYBUTYRATE CO 3 HYDROXYVALERATE); REACTIVE OXYGEN METABOLITE; SILVER NANOPARTICLE; SULFADIAZINE SILVER; SUPEROXIDE; TITANIUM DIOXIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ANTIANGIOGENIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; BIOMEDICINE; BURN; CONCENTRATION RESPONSE; CONTACT DERMATITIS; CYTOTOXICITY; DIABETIC RETINOPATHY; DNA DAMAGE; DRUG MECHANISM; EMBRYOTOXICITY; GYNECOLOGY; HUMAN; NANOTECHNOLOGY; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; REPRODUCTION; REPRODUCTIVE TOXICITY; RESPIRATORY CHAIN; REVIEW; SURGICAL APPROACH; TOXICITY; UTERINE CERVICITIS; UTERINE CERVIX EROSION; VAGINITIS; WOUND DRESSING; WOUND INFECTION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; DNA DAMAGE; HUMANS; METAL NANOPARTICLES; SILVER;

MUS; RATTUS;

EID: 84865137831     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1792-8     Document Type: Review

References (81)

1. Singh N, Manshian B, Jenkins GJ, Griffiths SM, Williams PM, Maffeis TG, Wright CJ, Doak SH (2009) NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30:3891-3914
2. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839 (Pubitemid 40984181)
3. Dobrovolskaia MA, McNeil SE (2007) Immunological properties of engineered nanomaterials. Nat Nanotechnol 2:469-478 (Pubitemid 47220069)
4. Hirano S (2009) A current overview of health effect research on nanoparticles. Environ Health Prev Med 14:223-225
5. Zhao Y, Xing G, Chai Z (2008) Nanotoxicology: are carbon nanotubes safe? Nat Nanotechnol 3:191-192 (Pubitemid 351499406)
6. Seiler HG, Sigel H, Sigel A (1988) Handbook on toxicity of inorganic compounds. Marcel Dekker, New York
7. Dibrov P, Dzioba J, Gosink KK, Hase CC (2002) Chemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae. Antimicrob Agents Chemother 46:2668-2670 (Pubitemid 34793484)
8. Benn TM, Westerhoff P (2008) Nanoparticle silver released into water from commercially available sock fabrics. Environ Sci Technol 42:4133-4139 (Pubitemid 351770073)
9. Tolaymat TM, El Badawy AM, Genaidy A, Scheckel KG, Luxton TP, Suidan M (2010) An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: a systematic review and critical appraisal of peer-reviewed scientific papers. Sci Total Environ 408:999-1006
10. Li Q, Mahendra S, Lyon DY, Brunet L, Liga MV, Li D, Alvarez PJ (2008) Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. Water Res 42:4591-4602
11. Silver S, Phung LT (1996) Bacterial heavy metal resistance: new surprises. Annu Rev Microbiol 50:753-789 (Pubitemid 26337481)
12. Li YF, Chen C (2011) Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small 7:2965-2980
13. Cowart DA, Guida SM, Shah SI, Marsh AG (2011) Effects of Ag nanoparticles on survival and oxygen consumption of zebra fish embryos, Danio rerio. J Environ Sci Health A 46:1122-1128
14. Posgai R, Cipolla-McCulloch CB, Murphy KR, Hussain SM, Rowe JJ, Nielsen MG (2011) Differential toxicity of silver and titanium dioxide nanoparticles on Drosophila melanogaster development, reproductive effort, and viability: size, coatings and antioxidants matter. Chemosphere 85:34-42
15. Vega-Villa KR, Takemoto JK, Yanez JA, Remsberg CM, Forrest ML, Davies NM (2008) Clinical toxicities of nanocarrier systems. Adv Drug Deliv Rev 60:929-938
16. Paula MMD, Franco CV, Baldin MU, Larissa RSA, Tatiana BC, Savi GD, Bellato LF, Fiori WA, da Silva L (2009) Synthesis, characterization and antibacterial activity studies of poly-{styrene-acrylic acid} with silver nanoparticles. Mater Sci Eng C 29:647-650
17. Cho KH, Park JE, Osaka T, Park SG (2005) The study of antimicrobial activity and preservative effects of nanosilver ingredient. Electrochim Acta 51:956-960 (Pubitemid 41550326)
18. Lee BU, Yun SH, Ji JH, Bae GN (2008) Inactivation of S. epidermidis, B. subtilis, and E. coli bacteria bioaerosols deposited on a filter utilizing airborne silver nanoparticles. J Microbiol Biotechnol 18:176-182
19. Zodrow K, Brunet L, Mahendra S, Li D, Zhang A, Li QL, Alvarez PJJ (2009) Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal. Water Res 43:715-723
20. Panacek A, Kolar M, Vecerova R, Prucek R, Soukupova J, Krystof V, Hamal P, Zboril R, Kvitek L (2009) Antifungal activity of silver nanoparticles against Candida spp. Biomaterials 30:6333-6340
21. Lara HH, Ayala-Nunez NV, Ixtepan-Turrent L, Rodriguez-Padilla C (2010) Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnol 8:1
22. Roe D, Karandikar B, Bonn-Savage N, Gibbins B, Roullet JB (2008) Antimicrobial surface functionalization of plastic catheters by silver nanoparticles. J Antimicrob Chemother 61:869-876 (Pubitemid 351426072)
23. Totaro P, Rambaldini M (2009) Efficacy of antimicrobial activity of slow release silver nanoparticles dressing in post-cardiac surgery mediastinitis. Interact Cardiovasc Thorac Surg 8:153-154
24. Furno F, Morley KS, Wong B, Sharp BL, Arnold PL, Howdle SM, Bayston R, Brown PD, Winship PD, Reid HJ (2004) Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection? J Antimicrob Chemother 54:1019-1024 (Pubitemid 40136734)
25. Xing ZC, Chae WP, Baek JY, Choi MJ, Jung Y, Kang IK (2010) In vitro assessment of antibacterial activity and cytocompatibility of silver-containing PHBV nanofibrous scaffolds for tissue engineering. Biomacromolecules 11:1248-1253
26. Alt V, Bechert T, Steinrucke P, Wagener M, Seidel P, Dingeldein E, Domann E, Schnettler R (2004) An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials 25:4383-4391 (Pubitemid 38388599)
27. Chen J, Han CM, Lin XW, Tang ZJ, Su SJ (2006) [Effect of silver nanoparticle dressing on second degree burn wound]. Zhonghua Wai Ke Za Zhi 44:50-52
28. 2 composites. Carbohydr Polym 78:54-59
29. Madhumathi K, Sudheesh Kumar PT, Abhilash S, Sreeja V, Tamura H, Manzoor K, Nair SV, Jayakumar R (2010) Development of novel chitin/nanosilver composite scaffolds for wound dressing applications. J Mater Sci-Mater Med 21:807-813
30. Wiegand C, Heinze T, Hipler UC (2009) Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate. Wound Repair Regen 17:511-521
31. Olson ME, Wright JB, Lam K, Burrell RE (2000) Healing of porcine donor sites covered with silver-coated dressings. Eur J Surg 166:486-489 (Pubitemid 30399336)
32. Wright JB, Lam K, Buret AG, Olson ME, Burrell RE (2002) Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair Regen 10:141-151 (Pubitemid 34760892)
33. Ip M, Lui SL, Poon VK, Lung I, Burd A (2006) Antimicrobial activities of silver dressings: an in vitro comparison. J Med Microbiol 55:59-63 (Pubitemid 43031239)
34. Bhol KC, Alroy J, Schechter PJ (2004) Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model. Clin Exp Dermatol 29:282-287 (Pubitemid 38658472)
35. Bhol KC, Schechter PJ (2005) Topical nanocrystalline silver cream suppresses inflammatory cytokines and induces apoptosis of inflammatory cells in a murine model of allergic contact dermatitis. Br J Dermatol 152:1235-1242 (Pubitemid 40933423)
36. Nadworny PL, Wang J, Tredget EE, Burrell RE (2008) Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model. Nanomedicine 4:241-251
37. Nadworny PL, Wang J, Tredget EE, Burrell RE (2010) Anti-inflammatory activity of nanocrystalline silver-derived solutions in porcine contact dermatitis. J Inflamm (Lond) 7:13
38. Greulich C, Diendorf J, Gessmann J, Simon T, Habijan T, Eggeler G, Schildhauer TA, Epple M, Koller M (2011) Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticles. Acta Biomater 7:3505-3514
39. Shin SH, Ye MK, Kim HS, Kang HS (2007) The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int Immunopharmacol 7:1813-1818 (Pubitemid 350046433)
40. Gurunathan S, Lee KJ, Kalishwaralal K, Sheikpranbabu S, Vaidyanathan R, Eom SH (2009) Antiangiogenic properties of silver nanoparticles. Biomaterials 30:6341-6350
41. Kalishwaralal K, Barathmanikanth S, Pandian SR, Deepak V, Gurunathan S (2010) Silver nano-a trove for retinal therapies. J Controlled Release 145:76-90
42. Sheikpranbabu S, Kalishwaralal K, Venkataraman D, Eom SH, Park J, Gurunathan S (2009) Silver nanoparticles inhibit VEGF-and IL-1beta-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells. J Nanobiotechnol 7:8
43. Sheikpranbabu S, Kalishwaralal K, Lee KJ, Vaidyanathan R, Eom SH, Gurunathan S (2010) The inhibition of advanced glycation end-products-induced retinal vascular permeability by silver nanoparticles. Biomaterials 31:2260-2271
44. Wang HJ, Yang L, Yang HY, Wang K, Yao WG, Jiang K, Huang XL, Zheng Z (2010) Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes. J Inorg Biochem 104:87-91
45. Sur I, Cam D, Kahraman M, Baysal A, Culha M (2010) Interaction of multi-functional silver nanoparticles with living cells. Nanotechnology 21:175104
46. Asharani PV, Hande MP, Valiyaveettil S (2009) Anti-proliferative activity of silver nanoparticles. BMC Cell Biol 10:65
47. Arakawa H, Neault JF, Tajmir-Riahi HA (2001) Silver(I) complexes with DNA and RNA studied by Fourier transform infrared spectroscopy and capillary electrophoresis. Biophys J 81:1580-1587 (Pubitemid 32783598)
48. Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC (2010) Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci 116:577-589
49. Li PW, Kuo TH, Chang JH, Yeh JM, Chan WH (2010) Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles. Toxicol Lett 197:82-87
50. Liu ZM, Stout JE, Boldin M, Rugh J, Diven WF, Yu VL (1998) Intermittent use of copper-silver ionization for Legionella control in water distribution systems: a potential option in buildings housing individuals at low risk of infection. Clin Infect Dis 26:138-140 (Pubitemid 28068167)
51. Park HJ, Kim JY, Kim J, Lee JH, Hahn JS, Gu MB, Yoon J (2009) Silver-ion-mediated reactive oxygen species generation affecting bactericidal activity. Water Res 43:1027-1032
52. Silver S (2003) Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 27:341-353 (Pubitemid 36694661)
53. Gupta A, Phung LT, Taylor DE, Silver S (2001) Diversity of silver resistance genes in IncH incompatibility group plasmids. Microbiology 147:3393-3402 (Pubitemid 33150346)
54. Pal S, Tak YK, Song JM (2007) Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Appl Environ Microbiol 73:1712-1720 (Pubitemid 46449051)
55. Choi O, Deng KK, Kim NJ, Ross L Jr, Surampalli RY, Hu Z (2008) The inhibitory effects of silver nanoparticles, silver ions, and silver chloride colloids on microbial growth. Water Res 42:3066-3074
56. Choi OK, Hu ZQ (2009) Nitrification inhibition by silver nanoparticles. Water Sci Technol 59:1699-1702
57. Su HL, Chou CC, Hung DJ, Lin SH, Pao IC, Lin JH, Huang FL, Dong RX, Lin JJ (2009) The disruption of bacterial membrane integrity through ROS generation induced by nanohybrids of silver and clay. Biomaterials 30:5979-5987
58. Gordon O, Vig Slenters T, Brunetto PS, Villaruz AE, Sturdevant DE, Otto M, Landmann R, Fromm KM (2010) Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction. Antimicrob Agents Chemother 54:4208-4218
59. Wei L, Tang J, Zhang Z, Chen Y, Zhou G, Xi T (2010) Investigation of the cytotoxicity mechanism of silver nanoparticles in vitro. Biomed Mater 5:044103
60. Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY (2009) Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol in Vitro 23:1076-1084
61. Burda C, Chen X, Narayanan R, El-Sayed MA (2005) Chemistry and properties of nanocrystals of different shapes. Chem Rev 105:1025-1102 (Pubitemid 40600877)
62. Vanwinkle BA, Bentley KLD, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdorster G, Gunter TE (2009) Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response. Nanotoxicology 3:307-318
63. Hsin YH, Chen CF, Huang S, Shih TS, Lai PS, Chueh PJ (2008) The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett 179:130-139
64. Boonstra J, Post JA (2004) Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337:1-13 (Pubitemid 38970100)
65. AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279-290
66. Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344 (Pubitemid 37321833)
67. Hirakawa K, Mori M, Yoshida M, Oikawa S, Kawanishi S (2004) Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radic Res 38:439-447 (Pubitemid 38618365)
68. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ (2005) In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol in Vitro 19:975-983 (Pubitemid 41563236)
69. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y (2008) DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 233:404-410
70. Wang J, Chen C, Liu Y, Jiao F, Li W, Lao F, Li Y, Li B, Ge C, Zhou G, Gao Y, Zhao Y, Chai Z (2008) Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases. Toxicol Lett 183:72-80
71. Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ (2010) Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 242:263-269
72. Hossain Z, Huq F (2002) Studies on the interaction between Ag(+) and DNA. J Inorg Biochem 91:398-404 (Pubitemid 34879173)
73. Park EJ, Yi J, Kim Y, Choi K, Park K (2010) Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol in Vitro 24:872-878
74. Jacobsen NR, Pojana G, White P, Moller P, Cohn CA, Korsholm KS, Vogel U, Marcomini A, Loft S, Wallin H (2008) Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells. Environ Mol Mutagen 49:476-487
75. Mroz RM, Schins RP, Li H, Drost EM, Macnee W, Donaldson K (2007) Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line. J Physiol Pharmacol 58(Suppl 5):461-470 (Pubitemid 351346695)
76. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC (2005) In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88:412-419 (Pubitemid 41672149)
77. Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess KL, Jones RL, Schlager JJ (2008) Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 112:13608-13619
78. Hussain SM, Schlager JJ (2009) Safety evaluation of silver nanoparticles: inhalation model for chronic exposure. Toxicol Sci 108:223-224
79. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6:1794-1807 (Pubitemid 44327550)
80. Balbus JM, Maynard AD, Colvin VL, Castranova V, Daston GP, Denison RA, Dreher KL, Goering PL, Goldberg AM, Kulinowski KM, Monteiro-Riviere NA, Oberdorster G, Omenn GS, Pinkerton KE, Ramos KS, Rest KM, Sass JB, Silbergeld EK, Wong BA (2007) Meeting report: hazard assessment for nanoparticles-report from an interdisciplinary workshop. Environ Health Perspect 115:1654-1659
81. Samberg ME, Oldenburg SJ, Monteiro-Riviere NA (2010) Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect 118:407-413