Risk of placenta-mediated pregnancy complications or pregnancy-related VTE in VTE-asymptomatic families of probands with VTE and heterozygosity for factor V Leiden or G20210 prothrombin mutation

European Journal of Haematology

Volumn 89, Issue 3, 2012, Pages 250-255

  Cordoba, Iris ^a   Pegenaute, Carlota ^a   González López, Tomás José ^b   Chillon, Carmen ^a   Sarasquete, Maria Eugenia ^a   Martin Herrero, Francisco ^a   Guerrero, Carmen ^c   Cabrero, Mónica ^a   Garcia Sanchez, Maria Helena ^a   Pabon, Pedro ^a   Lozano, Francisco Santiago ^a   Gonzalez, Marcos ^a   Alberca, Ignacio ^a   González Porras, José Ramón ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE BURGOS   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Factor V Leiden; G210210 prothrombin mutation; Placenta mediated pregnancy complications; Pregnancy associated VTE; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; PLACENTA DISORDER; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

FACTOR V; FEMALE; HETEROZYGOTE; HUMANS; MUTATION; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PROTHROMBIN; VENOUS THROMBOEMBOLISM;

EID: 84865129573     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2012.01809.x     Document Type: Article

References (33)

1. Rees DC, Cox M, Clegg JB World distribution of factor V Leiden. Lancet 1995;346:1133-4.
2. Rosendaal FR, Doggen CJ, Zivelin A, et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998;79:706-8.
3. Heit J, Kobbervig C, James A, et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism during pregnancy or the puerperium: a 30-year population based study. Ann Intern Med 2005;143:697-706.
4. Rutherford S, Montoro M, McGehee W, et al. Thromboembolic disease associated with pregnancy: an 11-year review. Am J Obstet Gynecol 1995;173:210-3.
5. Greer IA Prevention and management of venous thromboembolism in pregnancy. Clin Chest Med 2003;24:123-37.
6. McColl MD, Walker ID, Greer IA The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. BJOG 1999;75:387-8.
7. Pomp ER, Lenselink AM, Rosendaal FR, et al. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thromb Haemost 2008;6:632-7.
8. Grandone E, Margaglione M, Colaizzo D, et al. Prothrombotic genetic risk factors and the occurrence of gestational hypertension with or without proteinuria. Thromb Haemost 1999;81:349-52.
9. Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost 1997;77:822-4.
10. Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999;340:9-13.
11. Kupferminc MJ, Many A, Bar-Am A, et al. Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia. BJOG 2002;109:1373-6.
12. Gris JC, Quere I, Monpeyroux F, et al. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent - the Nimes Obstetricians and Haematologists Study 5 (NOHA5). Thromb Haemost 1999;81:891-9.
13. Alfirevic Z, Roberts D, Martlew V How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review Eur J Obstet Gynecol Reprod Biol 2002;101:6-14.
14. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003;361:901-8.
15. Infante-Rivard C, Rivard GE, Yotov WV, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 2002;347:19-25.
16. Lindqvist PG, Svensson PJ, Marsaál K, et al. Activated protein C resistance (FV:q506) and pregnancy. Thromb Haemost 1999;81:532-7.
17. Dizon-Townson D, Miller C, Sibai B, et al. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol 2005;106:517-24.
18. Tormene D, de Stefano V, Grandone E, et al. The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study. J Thromb Haemost 2007;5:2193-6.
19. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000;183:S1-22.
20. Alexander GR, Kogan M, Martin J, et al. What are the fetal growth patterns of singletons, twins and triplets in the United States? Clin Obstet Gynecol 1998;41:114-25.
21. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
22. Poort SR, Rosendaal FR, Reitsma PH, et al. A common genetic variation in the 30-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-703.
23. Silver RM, Zhao Y, Spong CY, et al. Prothrombin gene G20210A mutation and obstetric complications. Obstet Gynecol 2010;115:14-20.
24. Coppens M, Folkeringa N, Teune MJ, et al. Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. J Thromb Haemost 2007;5:1444-8.
25. Said JM, Higgins JR, Moses EK, et al. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol 2010;115:5-13.
26. Villani M, Tiscia GL, Margaglione M, et al. Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying common inherited thrombophilias. J Thromb Haemost. 2011;10:223-8.
27. Phillips OP Venous thromboembolism in the pregnant woman. J Reprod Med, 2003;48:921-9.
28. Noboa S, Le Gal G, Lacut K, et al. Family history as a risk factor for venous thromboembolism. Thromb Res 2008;122:624-9.
29. Tosetto A, Frezzato M, Rodeghiero F Prevalence and risk factors of non-fatal venous thromboembolism in the active population of the VITA Project. J Thromb Haemost 2003;1:1724-9.
30. Robertson L, Wu O, Langhorne P, et al. Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006;132:171-96.
31. Middeldorp S, van Hylckama Vlieg A Does thrombophilia testing help in the clinical management of patients? Br J Haematol 2008;143:321-35.
32. Lussana F, Dentali F, Abbate R, et al. Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res 2009;124:e19-25.
33. Royal College of Obstetricians and Gynaecologists Guideline. Reducing the risk of thrombosis and embolism during pregnancy and the puerperium. http://www.rcog.org.uk/womens-health/clinical-guidance/reducing-risk-of-thrombosis-greentop37a.