Azithromycin in bronchiectasis: When should it be used?

The Lancet

Volumn 380, Issue 9842, 2012, Pages 627-629

  Wilson, Robert ^a   Wells, Athol U ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; PLACEBO;

ANTIBIOTIC THERAPY; BRONCHIECTASIS; CHRONIC DISEASE; CLINICAL PRACTICE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; FORCED EXPIRATORY VOLUME; HUMAN; LONG TERM CARE; LUNG FUNCTION TEST; NOTE; OUTCOME ASSESSMENT; PATIENT SELECTION; PHYSIOTHERAPY; POST HOC ANALYSIS; PRIORITY JOURNAL; QUESTIONNAIRE; RISK BENEFIT ANALYSIS; SCORING SYSTEM; TREATMENT DURATION;

EID: 84865118216     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)61261-6     Document Type: Note

References (10)

1. Wong C, Jayaram L, Karalus N, et al. Azithromycin for prevention of exacerbations in non-cystic fi brosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet 2012; 380: 660-67.
2. Malhotra-Kumar S, Lammens C, Coenen S, Van Herck K, Goossens H. Eff ect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet 2007; 369: 482-90.
3. Reinert RR, Reinert S, van der Linden M, Cil MY, Al-Lahham A, Appelbaum P. Antimicrobial susceptibility of Streptococcus pneumoniae in eight European countries from 2001 to 2003. Antimicrob Agents Chemother 2005; 49: 2903-13.
4. Albert RK, Connett J, Bailey WC, et al, for the COPD Clinical Research Network. Azithromycin for prevention of exacerbations of COPD. N Engl J Med 2011; 365: 689-98.
5. Davies G, Wells AU, Doff man S, Watanabe S, Wilson R. The eff ect of Pseudomonas aeruginosa on pulmonary function in patients with bronchiectasis. Eur Respir J 2006; 28: 974-79.
6. Habesoglu MA, Ugurlu AO, Eyuboglu FO. Clinical, radiologic and functional evaluation of 304 patients with bronchiectasis. Ann Thorac Med 2011; 6: 131-36.
7. Ooi GC, Khong HL, Chan-Yeung M, et al. High resolution CT quantifi cation of bronchiectasis: clinical and functional correlation. Radiology 2002; 225: 663-72.
8. Bhalla M, Turcios N, Aponte V, et al. Cystic fi brosis: scoring system with thin section CT. Radiology 1991; 179: 783-88.
9. Roberts HR, Wells AU, Milne DG, et al. Airfl ow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests. Thorax 2000; 55: 198-204.
10. Loebinger MR, Wells AU, Hansell DM, et al. Mortality in bronchiectasis: a long term study assessing the factors infl uencing survival. Eur Respir J 2009; 34: 843-49.