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1
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79955856369
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Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder
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Bang-Andersen B, Ruhland T, Jørgensen M, Smith G, Frederiksen K, Jensen KG et al. Discovery of 1-[2-(2, 4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem 2011;54:3206-21.
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Bang-Andersen, B.1
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Smith, G.4
Frederiksen, K.5
Jensen, K.G.6
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2
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84863403855
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Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder
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Mørk A, Pehrson A, Brennum LT, Møller Nielsen S, Zhong H, Lassen AB et al. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther 2012;340:666-75.
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J Pharmacol Exp Ther
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Mørk, A.1
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Møller Nielsen, S.4
Zhong, H.5
Lassen, A.B.6
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3
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84858618643
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Occupancy of the Serotonin Transporter after Administration of Lu AA21004 and its Relation to Plasma Concentration in Healthy Subjects
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Areberg J, Luntang-Jensen M, Søgaard B, Nilausen DØ. Occupancy of the Serotonin Transporter after Administration of Lu AA21004 and its Relation to Plasma Concentration in Healthy Subjects. Basic Clin Pharmacol Toxicol 2012;110:401-4.
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Basic Clin Pharmacol Toxicol
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Areberg, J.1
Luntang-Jensen, M.2
Søgaard, B.3
Nilausen, D.Ø.4
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4
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84857325123
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A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder
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Alvarez E, Perez V, Dragheim M, Loft H, Artigas F. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. Int J Neuropsychopharmacol 2011;18:1-12.
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Int J Neuropsychopharmacol
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Alvarez, E.1
Perez, V.2
Dragheim, M.3
Loft, H.4
Artigas, F.5
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5
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84861478411
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Absorption, metabolism, and excretion of an oral dose of [14C]-Lu AA21004 50 mg in healthy men
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Nilausen D, Højer A-M, Bendahl L. Absorption, metabolism, and excretion of an oral dose of [14C]-Lu AA21004 50 mg in healthy men. J Clin Pharmacol 2009;49:1113.
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Nilausen, D.1
Højer, A.-M.2
Bendahl, L.3
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6
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84865132386
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Effect of multiple doses of rifampicin on the single dose pharmacokinetics of Lu AA21004
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Wang Y, Wojtkowski T, Ross G, Smith S, Nomikos G. Effect of multiple doses of rifampicin on the single dose pharmacokinetics of Lu AA21004. J Clin Pharmacol 2010;50:1082.
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J Clin Pharmacol
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Wang, Y.1
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8
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84865132386
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Lack of effect of multiple doses of Lu AA21004 on the pharmacodynamics and pharmacokinetics of aspirin
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Wang Y, Zhang W, Agyeman A, Ross G, Astruc B, Nomikos G. Lack of effect of multiple doses of Lu AA21004 on the pharmacodynamics and pharmacokinetics of aspirin. J Clin Pharmacol 2010;50:1082.
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J Clin Pharmacol
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Wang, Y.1
Zhang, W.2
Agyeman, A.3
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Nomikos, G.6
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9
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79952774424
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An open-label, multiple-dose study in healthy adults to assess the drug interaction potential of Lu AA21004 using the Indiana cocktail
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Wang Y, Wojtkowski T, Hanson E, Harris S, Karim A. An open-label, multiple-dose study in healthy adults to assess the drug interaction potential of Lu AA21004 using the Indiana cocktail. J Clin Pharmacol 2009;49:1114.
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Wang, Y.1
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10
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79952774424
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Effect of Lu AA21004 on the pharmacokinetics and pharmacodynamics of ethinyl estradiol (30 μg) and levonorgestrel (150 μg) in healthy adult women
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Wang Y, Wojtkowski T, Devoti A, Priestley A, Karim A. Effect of Lu AA21004 on the pharmacokinetics and pharmacodynamics of ethinyl estradiol (30 μg) and levonorgestrel (150 μg) in healthy adult women. J Clin Pharmacol 2009;49:1114.
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11
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84861481289
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The effect of multiple-doses of fluconazole, or ketoconazole, on the single-dose pharmacokinetic profile of Lu AA21004 in healthy adult subjects
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Wang Y, Munsaka M, Hanson E, Serenko M, Medlock M, Nomikos G. The effect of multiple-doses of fluconazole, or ketoconazole, on the single-dose pharmacokinetic profile of Lu AA21004 in healthy adult subjects. AAPS J 2010;12(S2).
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AAPS J
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Wang, Y.1
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12
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79952756530
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Effect of food on the pharmacokinetics of Lu AA21004 in healthy volunteers
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Wang Y, Wojtkowski T, Agyemang A, Karim A. Effect of food on the pharmacokinetics of Lu AA21004 in healthy volunteers. J Clin Pharmacol 2009;49:1115.
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J Clin Pharmacol
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Wang, Y.1
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79952774424
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Relative bioavailability of two formulation of Lu AA21004
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Wang Y, Wojtkowski T, Agyemang A, Homery MC, Karim A. Relative bioavailability of two formulation of Lu AA21004. J Clin Pharmacol 2009;49:1114.
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84865120042
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Effects of multiple doses of Lu AA21004 on the single-dose pharmacokinetics and pharmacodynamics of diazepam
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Chen G, Wang Y, Lee RD, Zhao Z, Nomikos GG. Effects of multiple doses of Lu AA21004 on the single-dose pharmacokinetics and pharmacodynamics of diazepam. J Clin Pharmacol 2011;51:1350.
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J Clin Pharmacol
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Chen, G.1
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Nomikos, G.G.5
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15
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84865120042
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Effect of multiple doses of bupropion on the steady-state pharmacokinetics of Lu AA21004 in healthy adults
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Chen G, Wang Y, Nudurupati S, Nomikos GG, Serenko M. Effect of multiple doses of bupropion on the steady-state pharmacokinetics of Lu AA21004 in healthy adults. J Clin Pharmacol 2011;51:1350.
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(2011)
J Clin Pharmacol
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Chen, G.1
Wang, Y.2
Nudurupati, S.3
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Serenko, M.5
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84872598270
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Note
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ICH. ICH Harmonised Tripartite Guideline E6, Step 5: Guideline for Good Clinical Practice. Adopted by CPMP July 1996 (CPMP/ICH/135/95 & CPMP/768/97) and by FDA May 1997 (Guidance for Industry, ICH E6).
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