Suspected spontaneous reports of birth defects in the UK associated with the use of carbimazole and propylthiouracil in pregnancy

Journal of Thyroid Research

Volumn 2011, Issue , 2011, Pages

  Bowman, Pamela ^a   Vaidya, Bijay ^b  

^a ROYAL DEVON AND EXETER HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIMAZOLE; PROPYLTHIOURACIL;

ANENCEPHALUS; ANUS ATRESIA; AORTA COARCTATION; ARTICLE; AUTISM; BIRTH DEFECT; BREAST MALFORMATION; CHOANA ATRESIA; CLEFT PALATE; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DRUG USE; DUODENUM ATRESIA; EAR MALFORMATION; EMBRYOPATHY; EPISPADIAS; EYE MALFORMATION; FACE DYSMORPHIA; FALLOT TETRALOGY; FOOT MALFORMATION; HAND MALFORMATION; HEARING IMPAIRMENT; HEART SEPTUM DEFECT; HOLOPROSENCEPHALY; HUMAN; HYDROCEPHALUS; HYPOGONADISM; KIDNEY AGENESIS; LIMB MALFORMATION; LIVER DYSFUNCTION; MATERNAL TREATMENT; MUSCLE HYPOTONIA; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN JAUNDICE; NIPPLE MALFORMATION; NOSE MALFORMATION; OMPHALOCELE; PATENT VITELLOINTESTINAL DUCT; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SKIN APLASIA; SKULL MALFORMATION; SPINAL DYSRAPHISM; SPINE MALFORMATION; THYROID DISEASE; TOOTH MALFORMATION; TRACHEOESOPHAGEAL FISTULA; UMBILICAL MALFORMATION; UNITED KINGDOM; URINARY TRACT MALFORMATION;

EID: 84865095912     PISSN: 20908067     EISSN: 20420072     Source Type: Journal    
DOI: 10.4061/2011/235130     Document Type: Article

References (21)

1. G. E. Krassas, K. Poppe, and D. Glinoer, "Thyroid function and human reproductive health", Endocrine Reviews, vol. 31, no. 5, pp. 702-755, 2010.
2. P. Barbero, R. Valdez, H. Rodŕiguez et al., "Choanal atresia associated with maternal hyperthyroidism treated with methimazole: a case-control study", American Journal of Medical Genetics Part A, vol. 146, no. 18, pp. 2390-2395, 2008.
3. M. Seoud, A. Nassar, I. Usta, M. Mansour, I. Salti, and K. Younes, "Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester", American Journal of Perinatology, vol. 20, no. 2, pp. 59-62, 2003. (Pubitemid 36373501)
4. N. Foulds, I. Walpole, F. Elmslie, and S. Mansour, "Carbimazole embryopathy: an emerging phenotype", American Journal of Medical Genetics, vol. 132, no. 2, pp. 130-135, 2005. (Pubitemid 40093320)
5. A. K. Myers and W. Reardon, "Choanal atresia-a recurrent feature of foetal carbimazole syndrome", Clinical Otolaryngology, vol. 30, pp. 364-383, 2005.
6. D. Wolf, N. Foulds, and H. Daya, "Antenatal carbimazole and choanal atresia: a new embryopathy", Archives of Otolaryngology-Head and Neck Surgery, vol. 132, no. 9, pp. 1009-1011, 2006. (Pubitemid 44423385)
7. L. Kannan, S. Mishra, R. Agarwal, V. Kartikeyan, N. Gupta, and M. Kabra, "Carbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: a case report and review of literature", Birth Defects Research Part A, vol. 82, no. 9, pp. 649-651, 2008.
8. D. Koenig, A. Spreux, S. Hiéronimus et al., "Birth defects observed with maternal carbimazole treatment: six cases reported to Nice's Pharmacovigilance Center", Annales d'Endocrinologie, vol. 71, no. 6, pp. 535-542, 2010.
9. P. Bowman, N. J. Osborne, R. Sturley, and B. Vaidya, "Carbimazole Embryopathy: implications for the choice of antithyroid drugs in pregnancy", QJM. In press.
10. O. Diav-Citrin and A. Ornoy, "Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil", Teratology, vol. 65, no. 1, pp. 38-44, 2002. (Pubitemid 34024457)
11. R. H. Mortimer, G. R. Cannell, R. S. Addison, L. P. Johnson, M. S. Roberts, and I. Bernus, "Methimazole and propylthiouracil equally cross the perfused human term placental lobule", Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 9, pp. 3099-3102, 1997. (Pubitemid 27385681)
12. D. A. Wing, L. K. Millar, P. P. Koonings, M. N. Montoro, and J. H. Mestman, "A comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancy", American Journal of Obstetrics and Gynecology, vol. 170, no. 1, pp. 90-95, 1994. (Pubitemid 24084037)
13. M. Abalovich, N. Amino, L. A. Barbour et al., "Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline", Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 8, pp. S1-S47, 2007. (Pubitemid 47236338)
14. Medicines and Healthcare Products Regulatory Agency/Commission on Human Medicines, United Kingdom, http://www.mhra.gov. uk/.
15. S. H. S. Pearce, "Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK", Clinical Endocrinology, vol. 61, no. 5, pp. 589-594, 2004. (Pubitemid 39540360)
16. A. B. Emiliano, L. Governale, M. Parks, and D. S. Cooper, "Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008", Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 5, pp. 2227-2233, 2010.
17. F. Azizi and A. Amouzegar, "Management of hyperthyroidism during pregnancy and lactation", European Journal of Endocrinology, vol. 164, no. 6, pp. 871-876, 2011.
18. H. Rosenfeld, A. Ornoy, S. Shechtman, and O. Diav-Citrin, "Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study", British Journal of Clinical Pharmacology, vol. 68, no. 4, pp. 609-617, 2009.
19. F. A. Karlsson, O. Axelsson, and H. Melhus, "Severe embryopathy and exposure to methimazole in early preganancy", Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 2, pp. 947-948, 2002.
20. M. Clementi, E. Di Gianantonio, M. Cassina et al., "Treatment of hyperthyroidism in pregnancy and birth defects", Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 11, pp. E337-E341, 2010.
21. N. Momotani, K. Ito, N. Hamada, Y. Ban, Y. Nishikawa, and T. Mimura, "Maternal hyperthyroidism and congenital malformation in the offspring", Clinical Endocrinology, vol. 20, no. 6, pp. 695-700, 1984. (Pubitemid 14105342)