Cardiovascular disease versus periodontal disease: Chronic systemic infection as a link

Journal of Clinical and Experimental Dentistry

Volumn 3, Issue 5, 2011, Pages

  Alonso Gonzalez R ^a   Perez Hernandez A ^b   Silvestre Rangil, J ^b   Silvestre, F J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Dr Peset University Hospital ^*

Author keywords

Actinobacillus Actinomycetemcomitans (Aa); Atheroma; Cardiovascular disease; Oral pathogens; Periodontal disease; Porphyromonas gingivalis (Pg)

Indexed keywords

EID: 84865065293     PISSN: None     EISSN: 19895488     Source Type: Journal    
DOI: 10.4317/jced.3.e476     Document Type: Article

References (28)

1. Meurman JH, Sanz M, Janket SJ. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med. 2004; 15: 403-13.
2. Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: Epidemiology and possible mechanisms. J Am Dent Assoc. 2002; 133 Suppl: 14S-22S
3. Spahr A, Klein E, Khuseyinova N, Boeckh C, Muche R, Kunze M, et al. Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. Arch Intern Med. 2006; 166: 554-9.
4. Pussinen PJ, Alfthan G, Rissanen H, Reunanen A, Asikainen S, Knekt P. Antibodies to periodontal pathogens and stroke risk. Stroke. 2004; 35: 2020-3.
5. Pussinen PJ, Jousilahti P, Alfthan G, Palosuo T, Asikainen S, Salomaa V. Antibodies to periodontal pathogens are associated with coronary heart disease. Arterioscler Thromb Vasc Biol. 2003; 23: 1250-4.
6. Pussinen PJ, Tuomisto K, Jousilahti P, Havulinna AS, Sundvall J, Salomaa V. Endotoxemia, immune response to periodontal pathogens, and systemic inflamation associate with incident cardiovascular disease events. Arterioscler Thtromb Vasc Biol. 2007; 27: 1433-9.
7. Milioti N, Bermudez-Fajardo A, Penichet ML, Oviedo-Orta E. Review article: antigen-induced immunomodulation in the patogénesis of aterosclerosis. Clin Dev Inmunol. 2008; 2008: 723539.
8. Cavrini F, Sambri V, Moter A, Servidio D, Marangoni A, Montebugnoli L, et al. Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. J Med Microbiol. 2005; 54: 93-6.
9. Ishihara K, Nabuchi A, Ito R, Miyachi K, Kuramitsu HK, Okuda K. Correlation between detection rates of periodontopathic bacterial DNA in carotid coronary stenotic artery plaque and in dental plaque samples. J Clin Microbiol. 2004; 42: 1313-5.
10. Brodala N, Merricks EP, Bellinger DA, Damrongsri D, Offenbacher S, Beck J, et al. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs.Arterioscler Thromb Vasc Biol. 2005; 25: 1446-51.
11. Roth GA, Aumayr K, Giacona MB, Papapanou PN, Schmidt AM, Lalla E. Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells. Thromb Res. 2009; 123: 780-4.
12. Ogawa T. Immunogiological properties of chemically defined lipid A from lipopolisaccharide of Porphiromonas (Bacteroides) gingivalis. Eur J Biochem. 1994; 219:737-42.
13. Gibson FC, Hong C, Chou H, Yumoto H, Chen J, Lien E, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004; 109: 2801-6.
14. Lourbakos A, Yuan YP, Jenkins AL, Travis J, Andrade-Gordon P, Santulli R, et al. Activation of protease-activated receptors by gingipains fron Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood. 2001; 97:3790-7.
15. Song H, Bélanger M, Whitlock J, Kozarov E, Progulske-Fox A. Hemaglutinin B is involved in the adherence of Porphyromonas gingivalis to human coronary artery endothelial cells. Infect Immun. 2005; 73: 7267-3.
16. Sakurai K, Wang D, Suzuki J, Umeda M, Nagasawa T, Izumi Y, et al. High incidente of actinobacillus actinomycetemcomitans infection in acute coronary syndrome. Int Heart J. 2007; 48: 663-75.
17. Miyamoto T, Yumoto H, Takahashi Y, Davey M, Gibson FC 3rd, Genco CA. Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun. 2006; 74:1376-80.
18. Chi H, Messas E, Levine RA, Graves DT & Amar S. Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and /or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation. 2004; 110: 1678-85.
19. Madan M, Bishayi B, Hoge M & Amar S. Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model. Atherosclerosis. 2008; 197:504-14.
20. Brodala N, Merricks EP, Bellinger DA, Damrongsri D, Offenbacher S, Beck J, et al. Porphyromonas gingivalis bacteremia Induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol. 2005; 25; 1446-51.
21. Li L, Messas E, Batista EL Jr, Robert A. Porphyromonas gingivalis infection accelerates the progression of aterosclerosis in a heterozygous apolipoprotein E- deficient murine model. Circulation. 2002; 105: 861-7.
22. Yamazaki K, Honda T, Domon H, Okui T, Kajita K, Amanuma R, et al. Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. Clin Exp Immunol. 2007; 149: 445-52.
23. Beck JD, Eke P, Heiss G, Madianos P, Couper D, Lin D, Moss K, et al. Periodontal disease and coronary heart disease: A reappraisal of the exposure.Circulation. 2005; 112: 19-24.
24. Pussinen PJ, Nyyssönen, Alfthan G, Salonen R, Laukkanen JA, Salonen JT. Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioescler Thromb Vasc Biol. 2005; 25: 833-8.
25. Demmer RT, Papapanou PN, Jacobs DR Jr, Desvarieux M. Evaluating clinical periodontal measures as surrogates for bacterial exposure: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). BMC Med Res Methodol. 2010; 10:2.
26. Davé S, Van Dyke TE. The link between periodontal disease and cardiovascular disease is probably inflammation. Oral Dis. 2008; 14:95-101.
27. Tonetti MS, DÁiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. Treatment of periodontitis and endothelial function. N Engl J Med. 2007; 356:911-20.
28. Matthews JB, Wright HJ, Roberts A, Ling-Mountford N, Cooper PR, Chapple IL. Neutrophil hyper-responsiveness in periodontitis. J Dent Res.2007; 86:718-22.