Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association consortium (BCAC)

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Hein, Rebecca ^a,b   Maranian, Melanie ^c   Hopper, John L ^d   Kapuscinski, Miroslaw K ^d   Southey, Melissa C ^d   Park, Daniel J ^d   Schmidt, Marjanka K ^e   Broeks, Annegien ^e   Hogervorst, Frans B L ^e   Bueno de Mesquit, H Bas ^f   Muir, Kenneth R ^g   Lophatananon, Artitaya ^g   Rattanamongkongul, Suthee ^h   Puttawibul, Puttisak ⁱ   Fasching, Peter A ^j,k   Hein, Alexander ^j   Ekici, Arif B ^l   Beckmann, Matthias W ^j   Fletcher, Olivia ^m   Johnson, Nichola ^m   dos Santos Silva, Isabel ⁿ   Peto, Julian ⁿ   Sawyer, Elinor ^o   Tomlinson, Ian ^p,q   Kerin, Michael ^r   Miller, Nicola ^s   Marmee, Frederick ^s   Schneeweiss, Andreas ^s   Sohn, Christof ^s   Burwinkel, Barbara ^a,s   Guénel, Pascal ^t,u   Cordina Duverger, Emilie ^t,u   Menegaux, Florence ^t,u   Truong, Thérèse ^t,u   Bojesen, Stig E ^v   Nordestgaard, Børge G ^v   Flyger, Henrik ^v   Milne, Roger L ^w   Perez, Jose Ignacio Arias ^x   Zamora, M Pilar ^y   Benítez, Javier ^w   Anton Culver, Hoda ^z   Ziogas, Argyrios ^z   Bernstein, Leslie ^aa   Clarke, Christina A ^ab   Brenner, Hermann ^a   Müller, Heiko ^a   Arndt, Volker ^a   Stegmaier, Christa ^ac   Rahman, Nazneen ^m   Seal, Sheila ^m   Turnbull, Clare ^m   Renwick, Anthony ^m   Meindl, Alfons ^ad   Schott, Sarah ^s   Bartram, Claus R ^s   Schmutzler, Rita K ^ae   Brauch, Hiltrud ^af   Hamann, Ute ^a   Ko, Yon Dschun ^ag   Wang Gohrke, Shan ^aj   Dörk, Thilo ^ak   Schürmann, Peter ^ak   Karstens, Johann H ^ak   Hillemanns, Peter ^ak   Nevanlinna, Heli ^al   Heikkinen, Tuomas ^al   Aittomäki, Kristiina ^al   Blomqvist, Carl ^ak,al   Bogdanova, Natalia V ^ak   Zalutsky, Iosif V ^am   Antonenkova, Natalia N ^am   Bermisheva, Marina ^an   Prokovieva, Darya ^an   Farahtdinova, Albina ^an   Khusnutdinova, Elza ^an   Lindblom, Annika ^ao   Margolin, Sara ^ao   Mannermaa, Arto ^ak,ao,aq   Kataja, Vesa ^ap,aq   Kosma, Veli Matti ^ap,aq   Hartikainen, Jaana ^ap,aq   Chen, Xiaoqing ^ar   Beesley, Jonathan ^ar   Lambrechts, Diether ^au,cf   Zhao, Hui ^au,cf   Neven, Patrick ^av   Wildiers, Hans ^av   Nickels, Stefan ^a   Flesch Janys, Dieter ^aw   Radice, Paolo ^ax,ay   Peterlongo, Paolo ^ax,ay   Manoukian, Siranoush ^ax   Barile, Monica ^az   Couch, Fergus J ^ba   Olson, Janet E ^ba   Wang, Xianshu ^ba   Fredericksen, Zachary ^ba   Giles, Graham G ^d,bb   Baglietto, Laura ^d,bb   McLean, Catriona A ^bc   Severi, Gianluca ^d,bb   Offit, Kenneth ^bd   Robson, Mark ^bd   Gaudet, Mia M ^be   Vijai, Joseph ^bd   Alnæs, Grethe Grenaker ^bf   Kristensen, Vessela ^bf,bg   Børresen Dale, Anne Lise ^bf,bg   John, Esther M ^ab,bh   Miron, Alexander ^bi   Winqvist, Robert ^bj   Pylkäs, Katri ^bj   Jukkola Vuorinen, Arja ^bk   Grip, Mervi ^bk   Andrulis, Irene L ^bl,bm,bn   Knight, Julia A ^bm,bo   Glendon, Gord ^bl   Mulligan, Anna Marie ^bn,bp   Figueroa, Jonine D ^bq   García Closas, Montserrat ^m,bq   Lissowska, Jolanta ^br   Sherman, Mark E ^bq   Hooning, Maartje ^bs   Martens, John W M ^bt   Seynaeve, Caroline ^bs   Collée, Margriet ^bs   Hall, Per ^ao   Humpreys, Keith ^ao   Czene, Kamila ^ao   Liu, Jianjun ^bu   Cox, Angela ^bv   Brock, Ian W ^bv   Cross, Simon S ^bv   Reed, Malcolm W R ^bv   Ahmed, Shahana ^c   Ghoussaini, Maya ^c   Pharoah, Paul DP ^c   Kang, Daehee ^bw   Yoo, Keun Young ^bw   Noh, Dong Young ^bw   Jakubowska, Anna ^bx   Jaworska, Katarzyna ^bx,by   Durda, Katarzyna ^bx   Złowocka, Elzbieta ^bx   Sangrajrang, Suleeporn ^bz   Gaborieau, Valerie ^ca   Brennan, Paul ^ca   McKay, James ^ca   Shen, Chen Yang ^cb,cc   Yu, Jyh Cherng ^cd   Hsu, Huan Ming ^cd   Hou, Ming Feng ^ce   Orr, Nick ^m   Schoemaker, Minouk ^m   Ashworth, Alan ^m   Swerdlow, Anthony ^m   Trentham Dietz, Amy ^at   Newcomb, Polly A ^as,at   Titus, Linda ^ai   Egan, Kathleen M ^ah   Chenevix Trench, Georgia ^ar   Antoniou, Antonis C ^c   Humphreys, Manjeet K ^c   Morrison, Jonathan ^c   Chang Claude, Jenny ^a   Easton, Douglas F ^c   Dunning, Alison M ^c   more..

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^f NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^g UNIVERSITY OF WARWICK   (United Kingdom)

^h Srinakhrainwirot University   (Thailand)

ⁱ PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^j UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^m INSTITUTE OF CANCER RESEARCH   (United Kingdom)

ⁿ LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^o GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^p UNIVERSITY OF OXFORD   (United Kingdom)

^q NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^r UNIVERSITY HOSPITAL GALWAY   (Ireland)

^s UNIVERSITY OF HEIDELBERG   (Germany)

^t NATIONAL INSTITUTES OF HEALTH   (United States)

^u CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^v GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^w Centro Nacional de Investigations Oncológicas   (Spain)

^x HOSPITAL MONTE NARANCO   (Spain)

^y HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^ab CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^ac SAARLAND CANCER REGISTRY   (Germany)

^ad TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ae UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^af UNIVERSITY OF TÜBINGEN   (Germany)

^ag Johanniter Krankenhaus   (Germany)

^ah H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^ai DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^aj UNIVERSITY OF ULM   (Germany)

^ak HANNOVER MEDICAL SCHOOL   (Germany)

^al HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^am Research Institute of Oncology and Medical Radiology of the Ministry of Health of the Byelorussian SSR   (Belarus)

^an INSTITUTE OF BIOCHEMISTRY AND GENETICS   (Russian Federation)

^ao KAROLINSKA INSTITUTE   (Sweden)

^ap UNIVERSITY OF EASTERN FINLAND   (Finland)

^aq KUOPIO UNIVERSITY HOSPITAL   (Finland)

^ar QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^as Fred Hutchinson Cancer Research Center   (United States)

^at UNIVERSITY OF WISCONSIN   (United States)

^au Vesalius Research Center   (Belgium)

^av UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^aw UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^ax NATIONAL CANCER INSTITUTE   (Italy)

^ay FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^az EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^ba MAYO CLINIC   (United States)

^bb CANCER EPIDEMIOLOGY CENTRE   (Australia)

^bc ALFRED HOSPITAL   (Australia)

^bd MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^be AMERICAN CANCER SOCIETY   (United States)

^bf OSLO UNIVERSITY HOSPITAL   (Norway)

^bg UNIVERSITY OF OSLO   (Norway)

^bh STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bi DANA FARBER CANCER INSTITUTE   (United States)

^bj UNIVERSITY OF OULU   (Finland)

^bk OULU UNIVERSITY HOSPITAL   (Finland)

^bl CANCER CARE ONTARIO   (Canada)

^bm MOUNT SINAI HOSPITAL   (Canada)

^bn UNIVERSITY OF TORONTO   (Canada)

^bo UNIVERSITY OF TORONTO   (Canada)

^bp ST MICHAEL'S HOSPITAL   (Canada)

^bq NATIONAL CANCER INSTITUTE   (United States)

^br INSTITUTE OF ONCOLOGY   (Poland)

^bs ERASMUS MEDICAL CENTER   (Netherlands)

^bt JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^bu GENOME INSTITUTE OF SINGAPORE   (Singapore)

^bv UNIVERSITY OF SHEFFIELD   (United Kingdom)

^bw Seoul National University College of Medicine   (South Korea)

^bx POMERANIAN MEDICAL UNIVERSITY   (Poland)

^by MEDICAL UNIVERSITY OF WARSAW   (Poland)

^bz NATIONAL CANCER INSTITUTE   (Thailand)

^ca INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^cb INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^cc Seoul National University College of Medicine ^*  (Taiwan)

^cd TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^ce KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^cf UNIVERSITY OF LEUVEN   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR;

ALLELE; ARTICLE; ASIAN; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; ETHNIC DIFFERENCE; ETHNIC GROUP; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIA; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 6; EUROPE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ESTROGEN; RISK FACTORS;

EID: 84865061552     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042380     Document Type: Article

References (14)

1. Zheng W, Long J, Gao YT, Li C, Zheng Y, et al. (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41: 324-328.
2. Stacey SN, Sulem P, Zanon C, Gudjonsson SA, Thorleifsson G, et al. (2010) Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. PLoS Genet 6: e1001029.
3. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, et al. (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 42: 504-507.
4. Laird NM, Mosteller F, (1990) Some statistical methods for combining experimental results. Int J Technol Assess Health Care 6: 5-30.
5. R Development Core Team (2005) R: A language and environment for statistical computing. Vienna, Austria, R Foundation for Statistical Computing.
6. Long J, Shu XO, Cai Q, Gao YT, Zheng Y, et al. (2010) Evaluation of breast cancer susceptibility Loci in chinese women. Cancer Epidemiol Biomarkers Prev 19: 2357-2365.
7. Antoniou AC, Kartsonaki C, Sinilnikova OM, Soucy P, McGuffog L, et al. (2011) Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 20(16): 3304-3321.
8. Cai Q, Wen W, Qu S, Li G, Egan KM, et al. (2011) Replication and Functional Genomic Analyses of the Breast Cancer Susceptibility Locus at 6q25.1 Generalize Its Importance in Women of Chinese, Japanese, and European Ancestry. Cancer Res 71: 1344-1355.
9. The Collaborative Oncological Gene-Environment Study (COGS) Project. Available: http://www.cogseu.org. Accessed 2012 Jul 10.
10. Ioannidis JPA, (2008) Why most discovered true associations are inflated. Epidemiology 19(5): 640-648.
11. Kraft P, (2008) Curses - winner's and otherwise - in genetic epidemiology. Epidemiology 19(5): 649-651.
12. Li WF, Hou SX, Yu B, Li MM, Ferec C, et al. (2010) Genetics of osteoporosis: accelerating pace in gene identification and validation. Hum Genet 127: 249-285.
13. Xie H, Sun M, Liao XB, Yuan LQ, Sheng ZF, et al. (2010) Estrogen receptor-alpha36 mediates a bone-sparing effect of 17beta-estrodiol in postmenopausal women. J Bone Miner Res 26: 156-168.
14. Dunbier AK, Anderson H, Ghazoui Z, Lopez-Knowles E, Pancholi S, et al. (2011) ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1. PLoS Genet 7: e1001382.