Reduced costs for staphylococcus aureus carriers treated prophylactically with mupirocin and chlorhexidine in cardiothoracic and orthopaedic surgery

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  van Rijen, Miranda M L ^a   Bode, Lonneke G M ^b   Baak, Diane A ^a   Kluytmans, Jan A J W ^a,c   Vos, Margreet C ^b  

^a AMPHIA HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE GLUCONATE; PLACEBO; PSEUDOMONIC ACID; SOAP;

ARTICLE; CONTROLLED STUDY; COST CONTROL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; ELECTIVE SURGERY; HOSPITAL COST; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; MULTICENTER STUDY; NONHUMAN; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SCREENING TEST; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; THORAX SURGERY;

ANTI-INFECTIVE AGENTS; CHLORHEXIDINE; HUMANS; MUPIROCIN; ORTHOPEDICS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; THORACIC SURGERY;

EID: 84865051122     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043065     Document Type: Article

References (23)

1. Williams RE, ((1963)) Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriol Rev 27:: 56--71.
2. Wertheim HF, Melles DC, Vos MC, Van Leeuwen W, Van Belkum, et al. ((2005)) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5(12):: 751--62.
3. Kluytmans J, Van Belkum A, Verbrugh H, ((1997)) Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10(3):: 505--20.
4. Kluytmans J, Mouton J, Yzerman E, Vandenbroucke-Grauls CM, Maat AW, et al. ((1995)) Nasal carriage of Staphylococcus aureus as a major risk factor for wound infections after cardiac surgery. J Infect Dis 171(1):: 216--9.
5. Wertheim HFL, Vos MC, Ott A, Voss A, Kluytmans JA, et al. ((2004)) Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients. Ann Intern Med 140:: 419--25.
6. Bode LGM, Kluytmans JAJW, Wertheim HFL, Bogaers D, Vandenbroucke-Grauls CM, et al. ((2010)) Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med 362(1):: 9--17.
7. Von Eiff C, Becker K, Machka K, Stammer H, Peters G, ((2001)) Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 344:: 11--6.
8. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR, ((1999)) The hospital infection control practices advisory committe guideline for the prevention of surgical site infection. Infect Control Hosp Epidemiol 20(4):: 247--80.
9. Boelaert JR, De Smedt RA, De Baere YA, Godard CA, Matthijs EG, et al. ((1989)) The influence of calcium mupirocin nasal ointment on the incidence of Staphylococcus aureus infections in haemodialysis patients. Nephrol Dial Transplant 4:: 278--81.
10. Garcia AM, Villa MV, Escudero ME, Gómez P, Vélez MM, et al. ((2003)) Use of nasal mupirocin for Staphylococcus aureus: effect on nasal carriers and nosocomial infections [Uso nasal de la mupirocona para Staphylococcus aureus: efecto en portadores y en infecciones nosocomiales]. Biomedica 23: 173--9.
11. Harbarth S, Dharan S, Liassine N, Herrault P, Auckenthaler R, et al. ((1999)) Randomised, placebo-controlled double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43(6):: 1412--6.
12. Kalmeijer MD, Coertjens H, Van Nieuwland-Bollen PM, Bogaers-Hofman D, de Baere GA, et al. ((2002)) Surgical site infections in orthopedic surgery: the effect of mupirocin nasal ointment in a double-blind, randomised, placebo-controlled trial. Clin Infect Dis 35(4):: 353--8.
13. Konvalinka A, Errett L, Fong IW, ((2006)) Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgery. J Hosp Infect 64(2):: 162--8.
14. Mup Study Group ((1996)) Nasal mupirocin prevents Staphylococcus aureus exit-site infection during peritoneal dialysis. J Am Soc Nephrol 7(11):: 2403--8.
15. Perl TM, Cullen JJ, Wenzel RP, Zimmerman MB, Pfaller MA, et al. ((2002)) Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 346(24):: 1871--1906.
16. Pérez-Fontan M, Rosales M, Rodriquez-Carmona A, Moncalián J, Fernández-Rivera C, et al. ((1992)) Treatment of Staphylococcus aureus nasal carriers in CAPD with mupirocin. Adv Perit Dial 8:: 242--5.
17. Van Rijen M, Bonten M, Wenzel R, Kluytmans J (2008) Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. Cochrane Database Syst Rev Issue 4. Art. No.: CD006216. DOI:10.1002/14651858.CD006216.pub2.
18. Wassenberg MWM, De Wit GA, Bonten MJM, ((2011)) Cost-effectiveness of preoperative screening and eradication of Staphylococcus aureus carriage. PLoS One. 6(5):: e14815.
19. Noskin GA, Rubin RJ, Schentag JJ, Kluytmans J, Hedblom EC, et al. ((2008)) Budget impact analysis of rapid screening for Staphylococcus aureus colonisation among patients undergoing elective surgery in US hospitals. Infect Control Hosp Epidemiol 29:: 16--24.
20. Courville XF, Tomek IM, Kirkland KB, Birhle M, Kantor SR, et al. ((2012)) Cost-effectiveness of preoperative nasal mupirocin treatment in preventing surgical site infection in patients undergoing total hip and knee arthroplasty: a cost-effectiveness analysis. Infect Control Hosp Epidemiol 33(2):: 152--9.
21. Cookson BD, ((1998)) The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 41(1):: 11--8.
22. Lee AS, Macedo-Vinas M, François P, Renzi G, Schrenzel J, et al. ((2011)) Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistant methicillin-resistant Staphylococcus aureus carriage after decolonisation therapy: a case-control study. Clin Infect Dis 52(12):: 1422--30.
23. Bode LG, Wertheim HF, Kuytmans JA, Bogaers-Hofman D, Vandenbroucke-Grauls CM, et al. ((2011)) Sustained low prevalence of meticillin-resistant Staphylococcus aureus upon admission to hospital in The Netherlands. J Hosp Infect 79(3):: 198--201.