The impact of repeated marathon running on cardiovascular function in the aging population

Journal of Cardiovascular Magnetic Resonance

Volumn 14, Issue 1, 2012, Pages

  Karlstedt, Erin ^a   Chelvanathan, Anjala ^a   Da Silva, Megan ^a   Cleverley, Kelby ^a   Kumar, Kanwal ^a   Bhullar, Navdeep ^a   Lytwyn, Matthew ^a   Bohonis, Sheena ^a   Oomah, Sacha ^a   Nepomuceno, Roman ^a   Du, Xiaozhou ^a   Melnyk, Steven ^a   Zeglinski, Matthew ^a   Ducas, Robin ^a   Sefidgar, Mehdi ^a   MacKenzie, Scott ^a   Sharma, Sat ^a   Kirkpatrick, Iain D ^a   Jassal, Davinder S ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cardiac biomarkers; Cardiac computed tomography; Cardiovascular magnetic resonance; Echocardiography; Marathon running

Indexed keywords

CREATINE KINASE; MYOGLOBIN; TROPONIN T;

ADULT; AGING; ARTICLE; ATHLETE; BODY MASS; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR MAGNETIC RESONANCE; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY OBSTRUCTION; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE SEVERITY; DOPPLER ECHOCARDIOGRAPHY; ENDOCARDIUM; FEMALE; FOLLOW UP; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE FIBROSIS; HEART RATE; HEART RIGHT ATRIUM; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE VOLUME; HUMAN; HUMAN EXPERIMENT; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MARATHON RUNNER; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; TISSUE DOPPLER IMAGING; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;

AGING; CARDIOMYOPATHIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; MYOCARDIUM; PHYSICAL ENDURANCE; PROSPECTIVE STUDIES; RUNNING; SEVERITY OF ILLNESS INDEX; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 84865048239     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-14-58     Document Type: Article

References (26)

1. Myocardial function in older male amateur marathon runners: assessment by tissue Doppler echocardiography, speckle tracking, and cardiac biomarkers. Knebel F, Schimke I, Schroeckh S, Peters H, Eddicks S, Schattke S, Brechtel L, Lock J, Wernecke KD, Dreger H, Grubitz S, Schmidt J, Baumann G, Borges AC, J Am Soc Echocardiogr 2009 Jul 22 7 803 809 10.1016/j.echo.2009.04.009
2. Marathon Study Investigators; Heinz Nixdorf Recall Study Investigators. Running: the risk of coronary events: Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Möhlenkamp S, Lehmann N, Breuckmann F, Bröcker-Preuss M, Nassenstein K, Halle M, Budde T, Mann K, Barkhausen J, Heusch G, Jöckel KH, Erbel R, Eur Heart J 2008 Aug 29 15 1903 1910 10.1093/eurheartj/ehn163
3. Altered left ventricular diastolic filling following a marathon is a reproducible phenomenon. Middleton N, Shave R, George K, Whyte G, Hart E, Oxborough D, Forster J, Gaze D, Int J Cardiol 2007 122 1 87 89 10.1016/j.ijcard.2006.11.042 17222472
4. The impact of marathon running upon ventricular function as assessed by 2D, Doppler, and tissue-Doppler echocardiography. Oxborough D, Shave R, Middleton N, Whyte G, Forster J, George K, Echocardiography 2006 23 8 635 641 10.1111/j.1540-8175.2006.00282.x 16970714
5. Preservation of ventricular function in amateur athletes after completion of a marathon. Kean AJ, McCloskey VR, Seghatol FF, Ewert GD, Mehlman DJ, McPherson DD, Rigolin VH, J Am Soc Echocardiogr 2006 Feb 19 2 202 205 10.1016/j.echo.2005.08.013
6. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu TT, Yoerger DM, Jassal DS, Lewandrowski KB, Siegel AJ, Marshall JE, Douglas PS, Lawlor D, Picard MH, Wood MJ, Circulation 2006 114 22 2325 2333 10.1161/CIRCULATIONAHA.106.647461 17101848
7. Cardiac injury markers in non-elite marathon runners. Jassal DS, Moffat D, Krahn J, Ahmadie R, Fang T, Eschun G, Sharma S, Int J Sports Med 2009 30 2 75 79 10.1055/s-0028-1104572 19177312
8. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Scharhag J, Herrmann M, Urhausen A, Haschke M, Herrmann W, Kindermann W, Am Heart J 2005 150 6 1128 1134 10.1016/j.ahj.2005.01.051 16338248
9. Exercise-induced cardiac troponin T release: a meta-analysis. Shave R, George KP, Atkinson G, Hart E, Middleton N, Whyte G, Gaze D, Collinson PO, Med Sci Sports Exerc 2007 39 12 2099 2106 10.1249/mss.0b013e318153ff78 18046180
10. Different effects of prolonged exercise on the right and left ventricles. Douglas PS, OToole ML, Hiller WD, Reichek N, J Am Coll Cardiol 1990 15 1 64 69 10.1016/0735-1097(90)90176-P 2295743
11. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Mousavi N, Czarnecki A, Kumar K, Fallah-Rad N, Lytwyn M, Han SY, Francis A, Walker JR, Kirkpatrick ID, Neilan TG, Sharma S, Jassal DS, Am J Cardiol 2009 103 10 1467 1472 10.1016/j.amjcard.2009.01.294 19427448
12. Acute cardiac effects of marathon running. Trivax JE, Franklin BA, Goldstein JA, Chinnaiyan KM, Gallagher MJ, deJong AT, Colar JM, Haines DE, McCullough PA, J Appl Physiol 2010 108 5 1148 1153 10.1152/japplphysiol.01151. 2009 20150567
13. Exercise-induced right ventricular dysfunction and structural remodeling in endurance athletes. La Gerche A, Burns AT, Mooney DJ, Inder WJ, Taylor A, Bogaert J, MacIsaac AI, Heidbuchel H, Prior DL, Eur Heart J 2012 33 998 1006 10.1093/eurheartj/ehr397 22160404
14. Myocardial late gadolinium enhancement: prevalence, pattern, and prognostic relevance in marathon runners. Breuckmann F, Möhlenkamp S, Nassenstein K, Lehmann N, Ladd S, Schmermund A, Sievers B, Schlosser T, Jöckel KH, Heusch G, Erbel R, Barkhausen J, Radiology 2009 251 1 50 57 10.1148/radiol.2511081118 19332846
15. Magnetic resonance imaging of myocardial injury and ventricular torsion after marathon running. Hanssen H, Keithahn A, Hertel G, Drexel V, Stern H, Schuster T, Lorang D, Beer AJ, Schmidt-Trucksass A, Nickel T, Weis M, Botnar R, Schwaiger M, Halle M, Clin Sci (Lond) 2011 120 4 143 152 10.1042/CS20100206
16. Troponin release following endurance exercise: Is inflammation the cause? a cardiovascular magnetic resonance study. OHanlon R, Wilson M, Wage R, Smith G, Alpendurada FD, Wong J, Dahl A, Oxborough D, Godfrey R, Sharma S, Roughton M, George K, Pennell DJ, Whyte G, Prasad SK, J Cardiovasc Magn Reson 2010 12 38 10.1186/1532-429X-12-38 20598139
17. Recommendations for chamber quantification. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St. John Sutton M, Stewart W, Eur J Echocardiogr 2006 7 2 79 108 10.1016/j.euje.2005.12.014 16458610
18. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB, J Am Soc Echocardiogr 2010 23 7 685 713 10.1016/j.echo.2010. 05.010 20620859
19. Dilatation and dysfunction of the right ventricle immediately after ultraendurance exercise: exploratory insights from conventional two-dimensional and speckle tracking echocardiography. Oxborough D, Shave R, Warburton D, Wiliams K, Oxborough A, Charlesworth S, Foulds H, Hoffman MD, Birch K, George K, Circ Cardiovasc Res 2011 4 253 256
20. Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists. Neumayr G, Pfister R, Mitterbauer G, Eibl G, Hoertnagl H, Am J Cardiol 2005 Sep 96 5 732 735 10.1016/j.amjcard.2005.04.054
21. Clinical significance of increased cardiac troponins T and I in participants of ultra-endurance events. Urhausen A, Scharhag J, Herrmann M, Kindermann W, Am J Cardiol 2004 Sep 94 5 696 698 10.1016/j.amjcard.2004.05.050
22. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Katus HA, Remppis A, Scheffold T, Diederich KW, Kuebler W, Am J Cardiol 1991 Jun 67 16 1360 1367 10.1016/0002-9149(91)90466-X
23. Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. Chen Y, Serfass RC, Mackey-Bojack SM, Kelly KL, Titus JL, Apple FS, J Appl Physiol 2000 May 88 5 1749 1755
24. Detection of myocardial scar by contrast-enhanced cardiac magnetic resonance imaging in patients with troponin-positive chest pain and minimal angiographic coronary artery disease. Christiansen JP, Edwards C, Sinclair T, Armstrong G, Scott A, Patel H, Hart H, Am J Cardiol 2006 97 6 768 771 10.1016/j.amjcard.2005.10.016 16516572
25. Troponin elevation after percutaneous coronary intervention directly represents the extent of irreversible myocardial injury: insights from cardiovascular magnetic resonance imaging. Selvanayagam JB, Porto I, Channon K, Petersen SE, Francis JM, Neubauer S, Banning AP, Circulation 2005 Mar 111 8 1027 1032 10.1161/01.CIR.0000156328.28485.AD
26. Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. Wilson M, OHanlon R, Prasad S, Deighan A, Macmillan P, Oxborough D, Godfrey R, Smith G, Maceira A, Sharma S, George K, Whyte G, J Appl Physiol 2011 110 6 1622 1626 10.1152/japplphysiol.01280.2010 21330616