Ceria nanoparticles reduce disease severity in a mouse model of multiple sclerosis

Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012

Volumn , Issue , 2012, Pages 265-268

  Decoteau, W E ^a   Heckman, K ^a   Reed, K ^b   Erlichman, J S ^a  

^a ST LAWRENCE UNIVERSITY   (United States)

^b Cerion Enterprises   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BALANCE BEAM; BLOOD-BRAIN BARRIER; BRAIN SLICES; BRAIN TISSUE; CEREBRAL ISCHEMIA; CERIA NANOPARTICLES; CERIUM OXIDE NANOPARTICLE; CLINICAL MEASURE; CLINICAL SYMPTOMS; DISEASE SEVERITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FREE RADICAL SCAVENGING PROPERTIES; IMMUNE CELLS; INFLAMMATORY DISORDERS; MICROGLIA; MOTOR DEFICITS; MOTOR PERFORMANCE; MOUSE MODELS; MULTIPLE SCLEROSIS; NANO-CERIA; NEUROLOGICAL DISEASE; NEUROPROTECTIVE EFFECTS; OXIDATIVE INJURY; PEROXYNITRITES; THERAPEUTIC AGENTS; THERAPEUTIC TREATMENTS; TREATMENT GROUP;

BRAIN; CELL DEATH; DISEASES; EXHIBITIONS; FREE RADICALS; INDUSTRIAL APPLICATIONS; MAMMALS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; NANOTECHNOLOGY; OXIDES; SENSORS; SPEED CONTROL; SYNTHESIS (CHEMICAL); WIRE;

CERIUM COMPOUNDS;

EID: 84865045526     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (9)

1. Carlson, N.G. and Rose, J.W. Antioxidants in Multiple Sclerosis Do They Have a Role in Therapy?. CNS Drugs 2006; 20 (6): 433-441
2. Gonsette RE. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J Neurol Sci 2008;274:48-53.
3. Cross AH, Manning PT, Keeling RM, Schmidt RE, Misko TP. Peroxynitrite formation within the central nervous system in active multiple sclerosis. J Neuroimmunol 1998;88:45-56.
4. Liu JS, Zhao ML, Brosnan CF, Lee SC. Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol 2001;158:2057-66.
5. Rejdak K, Eikelenboom MJ, Petzold A, Thompson EJ, Stelmasiak Z, Lazeron RH, et al. CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis. Neurology 2004;63:1439-45.
6. Hill KE, Zollinger LV, Watt HE, Carlson NG, Rose JW. Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage. J Neuroimmunol 2004;151:171-9.
7. Patil, S. Sandberg, A., Heckert, E., Self, W., and Sudipta Seal S. Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential. Biomaterials. 2007; 28(31): 4600-4607.
8. Estevez, A.Y., Pritchard, S., Harper, K., Aston, J.W., Lynch, A., Lucky, J.J., Ludington, J.S., Chartani, P.,Mosenthal, W.P., Leiter, J.C., and Erlichman, J.S. Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia Journal of Free Radical Biology and Medicine, 2011 Sep 15;51(6):1155-63.
9. Estevez, A. and Erlichman, J.S. Cerium Oxide Nanoparticles for the Treatment of Neurological Oxidative Stress Diseases. Oxidative Stress: Diagnostics, Prevention, and Therapy Chapter 9, pp 255-288 ACS Symposium Series, Vol. 1083. 2011.