The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress

European Neuropsychopharmacology

Volumn 22, Issue 9, 2012, Pages 651-656

  Christensen, Jane H ^a   Elfving, Betina ^b   Müller, Heidi K ^b   Fryland, Tue ^a   Nyegaard, Mette ^a   Corydon, Thomas J ^a   Nielsen, Anders Lade ^a   Mors, Ole ^b   Wegener, Gregers ^b,c   Børglum, Anders D ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Bipolar Disorder; BRD1 protein; Rats, Sprague Dawley; Schizophrenia; Stress, physiological

Indexed keywords

BROMODOMAIN CONTAINING PROTEIN 1; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H3K14; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION REGULATION; GENOTYPE ENVIRONMENT INTERACTION; HIPPOCAMPUS; HISTONE ACETYLATION; IMMOBILIZATION STRESS; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SCHIZOPHRENIA; UPREGULATION;

ANIMALS; BIPOLAR DISORDER; HIPPOCAMPUS; MALE; NERVE TISSUE PROTEINS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; SCHIZOPHRENIA; TIME FACTORS; UP-REGULATION;

EID: 84865044028     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.01.005     Document Type: Article

References (25)

1. Alfarez D.N., Joels M., Krugers H.J. Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro. Eur. J. Neurosci. 2003, 17:1928-1934.
2. Andersen C.L., Jensen J.L., Orntoft T.F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004, 64:5245-5250.
3. Bjarkam C.R., Corydon T.J., Olsen I.M., Pallesen J., Nyegaard M., Fryland T., Mors O., Borglum A.D. Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder. Brain Struct. Funct. 2009, 214:37-47.
4. Cerqueira J.J., Mailliet F., Almeida O.F., Jay T.M., Sousa N. The prefrontal cortex as a key target of the maladaptive response to stress. J. Neurosci. 2007, 27:2781-2787.
5. Conrad C.D., Galea L.A., Kuroda Y., McEwen B.S. Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behav. Neurosci. 1996, 110:1321-1334.
6. Covington H.E., Vialou V.F., Laplant Q., Ohnishi Y.N., Nestler E.J. Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. Neurosci. Lett. 2011, 493:122-126.
7. Datson N.A., Speksnijder N., Mayer J.L., Steenbergen P.J., Korobko O., Goeman J., de Kloet E.R., Joels M., Lucassen P.J. The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus 2012, 22:359-371.
8. Doyon Y., Cayrou C., Ullah M., Landry A.J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.J., Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol. Cell 2006, 21:51-64.
9. Ejchel-Cohen T.F., Wood G.E., Wang J.F., Barlow K., Nobrega J.N., McEwen S., Trevor Y.L. Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus. Brain Res. 2006, 1090:156-162.
10. Elfving B., Bonefeld B.E., Rosenberg R., Wegener G. Differential expression of synaptic vesicle proteins after repeated electroconvulsive seizures in rat frontal cortex and hippocampus. Synapse 2008, 62:662-670.
11. Hollis F., Duclot F., Gunjan A., Kabbaj M. Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus. Horm. Behav. 2011, 59:331-337.
12. Johnsson A., Durand-Dubief M., Xue-Franzen Y., Ronnerblad M., Ekwall K., Wright A. HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress. EMBO Rep. 2009, 10:1009-1014.
13. Kleen J.K., Sitomer M.T., Killeen P.R., Conrad C.D. Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav. Neurosci. 2006, 120:842-851.
14. Magarinos A.M., McEwen B.S. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors. Neuroscience 1995, 69:89-98.
15. McEwen B.S. Stress and hippocampal plasticity. Annu. Rev. Neurosci. 1999, 22:105-122.
16. McLaughlin K.J., Gomez J.L., Baran S.E., Conrad C.D. The effects of chronic stress on hippocampal morphology and function: an evaluation of chronic restraint paradigms. Brain Res. 2007, 1161:56-64.
17. McManus K.J., Hendzel M.J. CBP, a transcriptional coactivator and acetyltransferase. Biochem. Cell Biol. 2001, 79:253-266.
18. Mishima Y., Miyagi S., Saraya A., Negishi M., Endoh M., Endo T.A., Toyoda T., Shinga J., Katsumoto T., Chiba T., Yamaguchi N., Kitabayashi I., Koseki H., Iwama A. The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood 2011, 118:2443-2453.
19. Muller H.K., Wegener G., Elfving B. Chronic restraint stress affects serotonin transporter uptake kinetics but not binding sites in the rat hippocampus. Synapse 2012, 66:270-272.
20. Nyegaard M., Severinsen J.E., Als T.D., Hedemand A., Straarup S., Nordentoft M., McQuillin A., Bass N., Lawrence J., Thirumalai S., Pereira A.C., Kandaswamy R., Lydall G.J., Sklar P., Scolnick E., Purcell S., Curtis D., Gurling H.M., Mortensen P.B., Mors O., Borglum A.D. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 153B:582-591.
21. Orlowski, D., Elfving, B., Muller, H.K., Wegener, G., Bjarkam, C.R., in press. Wistar rats submitted to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins. Stress Early Online, 1-10. doi:. doi:10.3109/10253890.2011.643516.
22. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., Sklar P. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
23. Severinsen J.E., Bjarkam C.R., Kiaer-Larsen S., Olsen I.M., Nielsen M.M., Blechingberg J., Nielsen A.L., Holm I.E., Foldager L., Young B.D., Muir W.J., Blackwood D.H., Corydon T.J., Mors O., Borglum A.D. Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder. Mol. Psychiatry 2006, 11:1126-1138.
24. Vestergaard-Poulsen P., Wegener G., Hansen B., Bjarkam C.R., Blackband S.J., Nielsen N.C., Jespersen S.N. Diffusion-weighted MRI and quantitative biophysical modeling of hippocampal neurite loss in chronic stress. PLoS One 2011, 6:e20653.
25. Yun J., Koike H., Ibi D., Toth E., Mizoguchi H., Nitta A., Yoneyama M., Ogita K., Yoneda Y., Nabeshima T., Nagai T., Yamada K. Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4. J. Neurochem. 2010, 114:1840-1851.