Time is of the essence: MicroRNAs and age-associated neurodegeneration

Cell Research

Volumn 22, Issue 8, 2012, Pages 1218-1220

  Aw, Sherry ^a   Cohen, Stephen M ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; EIP74EF PROTEIN, DROSOPHILA; MICRORNA; MIRN34 MICRORNA, DROSOPHILA; TRANSCRIPTION FACTOR;

AGING; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN; CELL AGING; DEGENERATIVE DISEASE; DROSOPHILA; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; RISK FACTOR; TIME;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CELL AGING; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICRORNAS; NEURODEGENERATIVE DISEASES; RISK FACTORS; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84865043921     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.59     Document Type: Article

References (15)

1. Kenyon CJ. The genetics of ageing. Nature 2010; 464:504-512.
2. Slagboom PE, Beekman M, Passtoors WM, et al. Genomics of human lon-gevity. Philos Trans R Soc Lond B Biol Sci 2011; 366:35-42.
3. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010; 464:529-535.
4. Hébert SS, Horré K, Nicolaï L, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease cor-relates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA 2008; 105:6415-6420. (Pubitemid 351758360)
5. Kim J, Inoue K, Ishii J, et al. A Mi-croRNA feedback circuit in midbrain dopamine neurons. Science 2007; 317:1220-1224.
6. Gao J, Wang WY, Mao YW, et al. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Na-ture 2010; 466:1105-1109.
7. Edbauer D, Neilson JR, Foster KA, et al. Regulation of synaptic structure and function by FMRP-associated microR-NAs miR-125b and miR-132. Neuron 2010; 65:373-384.
8. Bilen J, Liu N, Burnett BG, Pittman RN, Bonini NM. MicroRNA pathways modulate polyglutamine-induced neu-rodegeneration. Mol Cell 2006; 24:157-163. (Pubitemid 44466675)
9. Karres JS, Hilgers V, Carrera I, Treis-man J, Cohen SM. The conserved mi-croRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Droso-phila. Cell 2007; 131:136-145. (Pubitemid 47498538)
10. Wang G, van der Walt JM, Mayhew G, et al. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet 2008; 82:283-289
11. Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat Neurosci 2008; 11:1137-1139.
12. Liu N, Landreh M, Cao K, et al. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature 2012; 482:519-523.
13. Jucker M, Walker LC. Pathogenic pro-tein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 2011; 70:532-540.
14. Stark A, Brennecke J, Bushati N, Rus-sell RB, Cohen SM. Animal MicroR-NAs confer robustness to gene expres-sion and have a signifcant impact on 3'UTR evolution. Cell 2005; 123:1133-1146. (Pubitemid 41785426)
15. Bushati N, Stark A, Brennecke J, Co-hen SM. Temporal reciprocity of miR-NAs and their targets during the mater-nal-to-zygotic transition in Drosophila. Curr Biol 2008; 18:501-506.