A novel genetically modified oncolytic vaccinia virus in experimental models is effective against a wide range of human cancers

Annals of Surgical Oncology

Volumn 19, Issue SUPPL. 3, 2012, Pages

  Haddad, Dana ^a,b   Chen, Nanhai ^c   Zhang, Qian ^c   Chen, Chun Hao ^a   Yu, Yong A ^c   Gonzalez, Lorena ^a   Aguilar, Jason ^c   Li, Pingdong ^a   Wong, Joyce ^a   Szalay, Aladar A ^b,c,d   Fong, Yuman ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c GENELUX CORPORATION   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GREEN FLUORESCENT PROTEIN; ONCOLYTIC VIRUS; ONCOLYTIC VIRUS GLV 1H151; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLUMINESCENCE; BREAST CANCER; CANCER CELL CULTURE; CELL SURVIVAL; CELL TYPE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DNA MODIFICATION; DOSE RESPONSE; DRUG SAFETY; IMMUNOHISTOCHEMISTRY; INDEL MUTATION; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; STOMACH CANCER; THYROID CANCER; TUMOR GROWTH; TUMOR XENOGRAFT; VACCINIA VIRUS; VIRUS DETECTION; VIRUS RECOMBINANT; VIRUS REPLICATION;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; FLOW CYTOMETRY; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; HUMANS; INJECTIONS, INTRALESIONAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, NUDE; NEOPLASMS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; PANCREATIC NEOPLASMS; VACCINIA VIRUS; VIRUS REPLICATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864998141     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-011-2198-x     Document Type: Article

References (18)

1. Leaf C. Why we're losing the war on cancer (and how to win it). Fortune. 2004;149:76-82, 84-76, 88ff.
2. S Garattini V Bertele 2002 Efficacy, safety, and cost of new anticancer drugs BMJ. 325 269 271 12153927 10.1136/bmj.325.7358.269
3. MJ Vaha-Koskela JE Heikkila AE Hinkkanen 2007 Oncolytic viruses in cancer therapy Cancer Lett. 254 178 216 17383089 10.1016/j.canlet.2007.02.002
4. A Brouquet B Nordlinger 2010 Neoadjuvant therapy of colorectal liver metastases: lessons learned from clinical trials J Surg Oncol. 102 932 936 21165995 10.1002/jso.21657
5. JM Davies RM Goldberg 2010 Optimum chemotherapy regimens for neoadjuvant therapy of hepatic colorectal metastases J Surg Oncol. 102 946 954 21165997 10.1002/jso.21653
6. R Adam E Hoti LC Bredt 2010 Evolution of neoadjuvant therapy for extended hepatic metastases-have we reached our (non-resectable) limit? J Surg Oncol. 102 922 931 21165994 10.1002/jso.21727
7. AP Venook 1997 Update on hepatic intra-arterial chemotherapy Oncology (Williston Park). 11 947 957 1:STN:280:DyaK2szpsVyjsA%3D%3D
8. Y Woo PS Adusumilli Y Fong 2006 Advances in oncolytic viral therapy Curr Opin Investig Drugs. 7 549 559 16784026 1:CAS:528:DC%2BD28XmsFyqtbc%3D
9. K Garber 2006 China approves world's first oncolytic virus therapy for cancer treatment J Natl Cancer Inst. 98 298 300 16507823 10.1093/jnci/djj111
10. Q Zhang YA Yu E Wang N Chen RL Danner PJ Munson, et al. 2007 Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus Cancer Res. 67 10038 10046 17942938 10.1158/0008-5472.CAN-07-0146 1:CAS:528:DC%2BD2sXhtFOnsLvJ
11. FG Falkner B Moss 1990 Transient dominant selection of recombinant vaccinia viruses J Virol. 64 3108 3111 2159565 1:CAS:528:DyaK3cXktVWmsbw%3D
12. ZS Guo SH Thorne DL Bartlett 2008 Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses Biochim Biophys Acta. 1785 217 231 18328829 1:CAS:528:DC%2BD1cXkvFWlurs%3D
13. R Vile D Ando D Kirn 2002 The oncolytic virotherapy treatment platform for cancer: unique biological and biosafety points to consider Cancer Gene Ther. 9 1062 1067 12522445 10.1038/sj.cgt.7700548 1:CAS:528:DC%2BD3sXhs1Ohsg%3D%3D
14. Esposito J, Fenner F. Poxviruses. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2001.
15. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva: WHO, 1988.
16. Q Zhang YA Yu E Wang N Chen RL Danner PJ Munson, et al. 2009 The highly attenuated oncolytic recombinant vaccinia virus GLV-1h68: comparative genomic features and the contribution of F14.5L inactivation Mol Genet Genomics. 282 417 435 19701652 10.1007/s00438-009-0475-1 1:CAS:528:DC%2BD1MXhtlymsLfJ
17. YA Yu C Galanis Y Woo N Chen Q Zhang Y Fong, et al. 2009 Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68 Mol Cancer Ther. 8 141 151 19139123 10.1158/1535-7163.MCT-08-0533 1:CAS:528:DC%2BD1MXjvFSmsQ%3D%3D
18. TC Liu T Hwang BH Park J Bell DH Kirn 2008 The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma Mol Ther. 16 1637 1642 18628758 10.1038/mt.2008.143 1:CAS:528:DC%2BD1cXhtVamt7nP