Methods for identification of CA125 from ovarian cancer ascites by high resolution mass spectrometry

International Journal of Molecular Sciences

Volumn 13, Issue 8, 2012, Pages 9942-9958

  Weiland, Florian ^a   Fritz, Katarina ^a   Oehler, Martin K ^b   Hoffmann, Peter ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Antibody; CA125; False positives; Mass spectrometry; Mucin 16; Ovarian cancer

Indexed keywords

ANTIBODY; CA 125 ANTIGEN; FIBRONECTIN; ISOPROTEIN; OC125 LIKE ANTIBODY; UNCLASSIFIED DRUG; TUMOR MARKER;

ANALYTICAL EQUIPMENT; ANTIGEN ANTIBODY REACTION; ARTICLE; ASCITES; CONTROLLED STUDY; CROSS REACTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC KIT; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE RESULT; FEMALE; HUMAN; INTERMETHOD COMPARISON; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULAR WEIGHT; OVARY CANCER; PROTEIN STRUCTURE; RELIABILITY; SENSITIVITY ANALYSIS; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; BLOOD; OVARIAN NEOPLASMS; PROCEDURES;

BLOTTING, WESTERN; CA-125 ANTIGEN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; OVARIAN NEOPLASMS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR MARKERS, BIOLOGICAL;

EID: 84864990348     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13089942     Document Type: Article

References (30)

1. Bast, R.C., Jr. Status of tumor markers in ovarian cancer screening. J. Clin. Oncol. 2003, 21, 200S-205S.
2. Bast, R.C., Jr.; Feeney, M.; Lazarus, H.; Nadler, L.M.; Colvin, R.B.; Knapp, R.C. Reactivity of a monoclonal antibody with human ovarian carcinoma. J. Clin. Invest. 1981, 68, 1331-1337.
3. Davelaar, E.M.; van Kamp, G.J.; Verstraeten, R.A.; Kenemans, P. Comparison of seven immunoassays for the quantification of CA 125 antigen in serum. Clin. Chem. 1998, 44, 1417-1422.
4. Bast, R.C., Jr.; Klug, T.L.; St John, E.; Jenison, E.; Niloff, J.M.; Lazarus, H.; Berkowitz, R.S.; Leavitt, T.; Griffiths, C.T.; Parker, L., et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med. 1983, 309, 883-887.
5. Bast, R.C., Jr.; Xu, F.J.; Yu, Y.H.; Barnhill, S.; Zhang, Z.; Mills, G.B. CA 125: The past and the future. Int. J. Biol. Markers 1998, 13, 179-187.
6. Seki, K.; Kikuchi, Y.; Uesato, T.; Kato, K. Increased serum CA 125 levels during the first trimester of pregnancy. Acta Obstet. Gynecol. Scand. 1986, 65, 583-585.
7. Miralles, C.; Orea, M.; Espana, P.; Provencio, M.; Sanchez, A.; Cantos, B.; Cubedo, R.; Carcereny, E.; Bonilla, F.; Gea, T. Cancer antigen 125 associated with multiple benign and malignant pathologies. Ann. Surg. Oncol. 2003, 10, 150-154.
8. Davis, H.M.; Zurawski, V.R., Jr.; Bast, R.C., Jr.; Klug, T.L. Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas. Cancer Res. 1986, 46, 6143-6148.
9. De los Frailes, M.T.; Stark, S.; Jaeger, W.; Hoerauf, A.; Wildt, L. Purification and characterization of the CA 125 tumor-associated antigen from human ascites. Tumour. Biol. 1993, 14, 18-29.
10. Kobayashi, H.; Ida, W.; Terao, T.; Kawashima, Y. Molecular characteristics of the CA 125 antigen produced by human endometrial epithelial cells: Comparison between eutopic and heterotopic epithelial cells. Am. J. Obstet. Gynecol. 1993, 169, 725-730.
11. Matsuoka, Y.; Nakashima, T.; Endo, K.; Yoshida, T.; Kunimatsu, M.; Sakahara, H.; Koizumi, M.; Nakagawa, T.; Yamaguchi, N.; Torizuka, K. Recognition of ovarian cancer antigen CA125 by murine monoclonal antibody produced by immunization of lung cancer cells. Cancer Res. 1987, 47, 6335-6340.
12. O'Brien, T.J.; Tanimoto, H.; Konishi, I.; Gee, M. More than 15 years of CA 125: What is known about the antigen, its structure and its function. Int. J. Biol. Markers 1998, 13, 188-195.
13. Yin, B.W.; Lloyd, K.O. Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J. Biol. Chem. 2001, 276, 27371-27375.
14. Nustad, K.; Lebedin, Y.; Lloyd, K.O.; Shigemasa, K.; de Bruijn, H.W.; Jansson, B.; Nilsson, O.; Olsen, K.H.; O'Brien, T.J. Epitopes on CA 125 from cervical mucus and ascites fluid and characterization of six new antibodies. Third report from the ISOBM TD-1 workshop. Tumour Biol. 2002, 23, 303-314.
15. Shojaeian, S.; Allameh, A.; Zarnani, A.H.; Chamankhah, M.; Ghods, R.; Bayat, A.A.; Jeddi-Tehrani, M. Production and characterization of monoclonal antibodies against the extracellular domain of CA 125. Immunol. Invest. 2010, 39, 114-131.
16. Kui Wong, N.; Easton, R.L.; Panico, M.; Sutton-Smith, M.; Morrison, J.C.; Lattanzio, F.A.; Morris, H.R.; Clark, G.F.; Dell, A.; Patankar, M.S. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. J. Biol. Chem. 2003, 278, 28619-28634.
17. Elschenbroich, S.; Ignatchenko, V.; Clarke, B.; Kalloger, S.E.; Boutros, P.C.; Gramolini, A.O.; Shaw, P.; Jurisica, I.; Kislinger, T. In-depth proteomics of ovarian cancer ascites: Combining shotgun proteomics and selected reaction monitoring mass spectrometry. J. Proteome Res. 2011, 10, 2286-2299.
18. Milutinovic, B.; Jankovic, M. Analysis of the protein and glycan partsof CA125 Antigen from human amniotic fluid. Arch. Biol. Sci. Belgrade 2007, 59, 97-103.
19. Andersch-Bjorkman, Y.; Thomsson, K.A.; Holmen Larsson, J.M.; Ekerhovd, E.; Hansson, G.C. Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle. Mol. Cell. Proteomics 2007, 6, 708-716.
20. Bouanene, H.; Miled, A. Conflicting views on the molecular structure of the cancer antigen CA125/MUC16. Dis. Markers 2010, 28, 385-394.
21. Klar, E.; Heene, D.L. Fibronectin. Klin. Wochenschr. 1984, 62, 963-974.
22. Kumar, V.; Hagler H.K. Interactive Case Study Companion to Robbins Pathologic Basis of Disease, 6th ed.; Saunders/Elsevier: Philadelphia, PA, USA, 1999.
23. Makarov, A.; Denisov, E.; Lange, O.; Horning, S. Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer. J. Am. Soc. Mass. Spectrom. 2006, 17, 977-982.
24. Milutinovic, B.; Mitic, N.; Jankovic, M. Identification of pregnancy-associated CA125-reactive protein as a carbohydrate-binding immunoglobulin G. Arch. Biochem. Biophys. 2010, 499, 69-76.
25. Hanisch, F.G.; Uhlenbruck, G.; Dienst, C.; Stottrop, M.; Hippauf, E. Ca 125 and Ca 19-9: Two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk. Eur. J. Biochem. 1985, 149, 323-330.
26. Gorg, A.; Drews, O.; Luck, C.; Weiland, F.; Weiss, W. 2-DE with IPGs. Electrophoresis 2009, 30, S122-S132.
27. Wisniewski, J.R.; Zougman, A.; Nagaraj, N.; Mann, M. Universal sample preparation method for proteome analysis. Nat. Methods 2009, 6, 359-362.
28. Penno, M.A.; Bacic, A.; Colegate, S.M.; Hoffmann, P.; Michalski, W.P. Identifying candidate serum biomarkers of exposure to tunicamycins in rats using two-dimensional electrophoresis. J. Proteome Res. 2009, 8, 2812-2826.
29. Avery, L. Mann-Whitney U Test. 2007. Available online: http://elegans.som.vcu.edu/~leon/stats/utest.html (accessed on 3 May 2012).
30. Hoofnagle, A.N.; Becker, J.O.; Wener, M.H.; Heinecke, J.W. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clin. Chem. 2008, 54, 1796-1804.