Common immunogenetic profile in children with multiple autoimmune diseases: The signature of HLA-DQ pleiotropic genes

Autoimmunity

Volumn 45, Issue 6, 2012, Pages 470-475

  Larizza, Daniela ^a   Calcaterra, Valeria ^a   Klersy, Catherine ^b   Badulli, Carla ^b   Caramagna, Claudia ^a   Ricci, Antonio ^a   Brambilla, Paola ^a   Salvaneschi, Laura ^b   Martinetti, Miryam ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

autoimmune disease; children; HLA DQ; multiple

Indexed keywords

HETERODIMER; HLA DQ ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN;

ADOLESCENT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE THYROIDITIS; CELIAC DISEASE; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOGENETICS; INSULIN DEPENDENT DIABETES MELLITUS; ITALY; MAJOR CLINICAL STUDY; MALE; PLEIOTROPY; SCHOOL CHILD;

ADULT; AUTOIMMUNE DISEASES; CELIAC DISEASE; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PLEIOTROPY; GENOTYPE; HLA-DQ ALPHA-CHAINS; HLA-DQ ANTIGENS; HLA-DQ BETA-CHAINS; HUMANS; IMMUNOGENETIC PHENOMENA; MALE; MIDDLE AGED; THYROIDITIS, AUTOIMMUNE; YOUNG ADULT;

EID: 84864976879     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.697594     Document Type: Article

References (26)

1. Sattar N, Lazare F, Kacer M, et al. Celiac disease in children, adolescents, and young adults with autoimmune thyroid disease. J Pediatr 2011;158:272-275.
2. Kakleas K, Karayianni C, Critselis E, et al. The prevalence and risk factors for coeliac disease among children and adolescents with type 1 diabetes mellitus. Diabetes Res Clin Pract 2010;90: 202-208.
3. Karavanaki K, Kakleas K, Paschali E, et al. Screening for associated autoimmunity in children and adolescents with type 1 diabetes mellitus (T1DM). Horm Res 2009;71:201-206.
4. Sumnik Z, Cinek O, Bratanic N, et al. Thyroid autoimmunity in children with coexisting type 1 diabetes mellitus and celiac disease: A multicenter study. J Pediatr Endocrinol Metab 2006; 19:517-522.
5. Jaeger C, Hatziagelaki E, Petzoldt R, et al. Comparative analysis of organ-specific autoantibodies and celiac disease- associated antibodies in type 1 diabetic patients, their firstdegree relatives, and healthy control subjects. Diabetes Care.2001;24:27-32.
6. Vandiedonck C, Beaurain G, Giraud M, et al. Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia. Proc Natl Acad Sci USA 2004 26;101:15464-15469.
7. Mazzilli MC, Ferrante P, Mariani P, et al. A study of Italian pediatric celiac disease patients confirms that the primary HLA association is to the DQ(alpha 1*0501, beta 1. *0201) heterodimer. Hum Immunol 1992;33:133-139.
8. De Block CE, De Leeuw H, Vertommen JJ, et al. Beta-cell, thyroid, gastric, adrenal and celiac autoimmunity and HLA-DQ types in type 1 diabetes. Belgian Diabetes Registry. Clin Exp Immunol 2001;126:236-241.
9. Wang H, He R. HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus. Chin Med Sci J 1993;8:231-234.
10. Margaritte-Jeannin P, Babron MC, Bourgey M, et al. HLA-DQ relative risks for celiac disease in European populations: A study of the European Genetics Cluster on Celiac Disease. Tissue Antigens 2004;63:562-567.
11. Reichstetter S, KwokWW, Nepom GT. Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1.0501/ DQB1.0302 trans class II heterodimer. Tissue Antigens 1999; 53:101-105.
12. Bratanic N, Smigoc Schweiger D, Mendez A, et al. An influence of HLA-A, B, DR, DQ, and MICA on the occurrence of Celiac disease in patients with type 1 diabetes. Tissue Antigens 2010;76:208-215.
13. Simell S, Hoppu S, Simell T, et al. Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth. iabetes Care 2010;33:774-779.
14. Catino M, Tumini S, Mezzetti A, et al. Celiac disease and diabetes mellitus in children: A non casual association. Diab Nutr Metab 1998;11:296-302.
15. Mackay IR. Clustering and commonalities among autoimmune diseases. J Autoimmun 2009;33:170-177.
16. Smyth DJ, Plagnol V, Walker NM, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008;359:2767-2777.
17. Acerini CL, Ahmed ML, Ross KM, et al. Celiac disease in children and adolescents with IDDM: Clinical characteristics and response to gluten-free diet. Diabet Med 1998;15:38-44.
18. Ventura A, Magazzù G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune disorders in celiac disease. Gastroenterology 1999;117:297-303.
19. Jankosky C, Deussing E, Gibson RL, et al. Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. Virus Res 2012;163:424-430.
20. Costenbader KH, Gay S, Riquelme ME, et al. Genes, epigenetic regulation and environmental factors: Which is the most relevant in developing autoimmune diseases?, Autoimmun Rev 2011 Oct 25. [Epub ahead of print]
21. Rewers M, Eisenbarth GS. Autoimmunity: Celiac disease in T1DM-the need to look long term. Nat Rev Endocrinol 2011; 8:5-8.
22. Ergür AT, Oç;al G, Berberoǧlu M, Adiyaman P, et al. Celiac disease and autoimmune thyroid disease in children with type 1 diabetes mellitus: Clinical and HLA-genotyping results. J Clin Res Pediatr Endocrinol 2010;2:151-154.
23. Picarelli A, Di Tola M, D'Amico T, et al. Type 1 diabetes mellitus and celiac disease: Endothelial dysfunction, Acta Diabetol. 2011 Sep 16. [Epub ahead of print]
24. Kim EY, Shin CH, Yang SW. Polymorphisms of HLA class II predispose children and adolescents with type 1 diabetes mellitus to autoimmune thyroid disease. Autoimmunity 2003; 36:177-181.
25. Spadaccino AC, Basso D, Chiarelli S, Albergoni MP, D'Odorico A, Plebani M, Pedini B, Lazzarotto F, Betterle C.Celiac disease in North Italian patients with autoimmune thyroid diseases. Autoimmunity 2008;41:116-121.
26. Eyre S, Hinks A, Bowes J, et al. Yorkshire Early Arthritis Consortium; Biologics in RA Control Consortium, Thomson W, Worthington J, Barton A. Overlapping genetic susceptibility variants between three autoimmune disorders: Rheumatoid arthritis, type 1 diabetes and celiac disease. Arthritis Res Ther 2010;12(5):R175.