Prospective assessment of fetalmaternal cell transfer in miscarriage and pregnancy termination

Human Reproduction

Volumn 27, Issue 9, 2012, Pages 2607-2612

  Peterson, S E ^a,b   Nelson, J L ^a,c   Guthrie, K A ^c   Gadi, V K ^c,d   Aydelotte, T M ^c   Oyer, D J ^a,e   Prager, S W ^a   Gammill, H S ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SWEDISH MEDICAL CENTER   (United States)

^c USA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e Aurora Medical Services   (United States)

Author keywords

cellular fetal microchimerism; fetal cell transfer; miscarriage; pregnancy; pregnancy termination

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CELL ISOLATION; CELL TRANSFER; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FETUS; FETUS CELL; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROCHIMERISM; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PREGNANCY TERMINATION; PREGNANT WOMAN; PROSPECTIVE STUDY; QUANTITATIVE ASSAY; SPONTANEOUS ABORTION; Y CHROMOSOME; CHIMERA; CYTOLOGY; FETOMATERNAL TRANSFUSION; GENETICS; INDUCED ABORTION; METHODOLOGY; MONONUCLEAR CELL; PATHOLOGY; PREGNANCY; ULTRASTRUCTURE;

ABORTION, INDUCED; ABORTION, SPONTANEOUS; ADOLESCENT; ADULT; CHIMERISM; CHROMOSOMES, HUMAN, Y; COHORT STUDIES; FEMALE; FETUS; GESTATIONAL AGE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MATERNAL-FETAL EXCHANGE; POLYMERASE CHAIN REACTION; PREGNANCY; PROSPECTIVE STUDIES;

EID: 84864953023     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des244     Document Type: Article

References (33)

1. Adams Waldorf K, Gammill H, Lucas J, Aydelotte T, Leisenring W, Lambert N, Nelson J. Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy. Placenta 2010;31:589-594.
2. Ariga H, Ohto H, Busch MP, Imamura S, Watson R, Reed W, Lee T. Kinetics of fetal cellular and cell-free DNA in the maternal circulation during and after pregnancy: implications for noninvasive prenatal diagnosis. Transfusion 2001;41:1524-1530. (Pubitemid 34072677)
3. Bianchi D, Zickwolf G, Weil G, Sylvester S, DeMaria M. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA 1996;93:705-708. (Pubitemid 26041153)
4. Bianchi D, Williams J, Sullivan L, Hanson F, Klinger K, Shuber A. PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies. Am J Hum Genet 1997;61:822-829. (Pubitemid 27418456)
5. Bianchi D, Farina A, Weber W, Delli-Bovi L, DeRiso M, Williams J, Klinger K. Significant fetal-maternal hemorrhage after termination of pregnancy: implications for development of fetal cell microchimerism. Am J Obstet Gynecol 2001;184:703-706. (Pubitemid 32234987)
6. Boklage C. Survival probability of human conceptions from fertilization to term. Int J Fertil 1990;35:75-94. (Pubitemid 20126959)
7. Cutler N, Heston L, Davies P, Haxby J, Schapiro M. Alzheimer's disease and down's syndrome: new insights. Ann Intern Med 1985;103:566-578.
8. Gadi V. Fetal microchimerism in breast from women with and without breast cancer. Breast Cancer Res Treat 2010;121:241-244.
9. Gadi V, Nelson J. Fetal microchimerism in women with breast cancer. Cancer Res 2007;67:9035-9038. (Pubitemid 47535887)
10. Gammill H, Nelson J. Naturally acquired microchimerism. Int J Dev Biol 2010;54:531-543.
11. Guthrie K, Dugowson C, Voigt L, Koepsell T, Nelson J. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum 2010;62:1842-1848.
12. Guttmacher Institute. Facts on induced abortion in the United States. 2011: http://www.guttmacher.org/pubs/fb-induced-abortion.html#5 (17 May 2011, date last accessed).
13. Johnson K, Samura O, Nelson J, McDonnell W, Bianchi D. Significant fetal cell microchimerism in a nontransfused woman with hepatitis C: evidence of long-term survival and expansion. Hepatology 2002; 36:1295-1297. (Pubitemid 35253450)
14. Jones R, Kooistra K. Abortion incidence and access to services in the United States, 2008. Perspect Sex Reprod Health 2011;43:41-50.
15. Khosrotehrani K, Johnson K, Lau J, Dupuy A, Cha D, Bianchi D. The influence of fetal loss on the presence of fetal cell microchimerism: a systematic review. Arthritis Rheum 2003;48:3237-3241. (Pubitemid 37409338)
16. Khosrotehrani K, Johnson K, Cha D, Salomon R, Bianchi D. Transfer of fetal cells with multilineage potential to maternal tissue. J Am Med Assoc 2004;292:75-80. (Pubitemid 38923796)
17. Lambert N, Lo Y, Erickson T, Tylee T, Guthrie K, Furst D, Nelson J. Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer. Blood 2002;100: 2845-2851.
18. Lo Y, Tein M, Lau T, Haines C, Leung T, Poon P, Wainscoat J, Johnson P, Chang A, Hjelm N. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 1998;62:768-775. (Pubitemid 28194317)
19. Lo Y, Lau T, Zhang J, Leung T, Chang A, Hjelm N, Elmes R, Bianchi D. Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with Trisomy 21. Clin Chem 1999a; 45:1747-1751. (Pubitemid 29477331)
20. Lo Y, Zhang J, Leung T, Lau T, Chang A, Hjelm N. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 1999b;64:218-224. (Pubitemid 30428975)
21. Lo Y, Lau T, Chan L, Leung T, Chang A. Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA. Clin Chem 2000;46:1301-1309.
22. McGrath H. Elective pregnancy termination and microchimerism: comment on the article by Khosrotehrani et al. Arthritis Rheum 2004; 50:3058-3059.
23. Nelson J, Furst D, Maloney S, Gooley T, Evans P, Smith A, Bean M, Ober C, Bianchi D. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 1998;351:559-562. (Pubitemid 28077562)
24. Pahal G, Jauniaux E, Kinnon C, Thrasher A, Rodeck C. Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation. Am J Obstet Gynecol 2000;183:1029-1034.
25. Sato T, Fujimori K, Sato A, Ohto H. Microchimerism after induced or spontaneous abortion. Obstet Gynecol 2008;112:593-597.
26. Schupf N, Kapell D, Lee J, Ottman R, Mayeux R. Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome. Lancet 1994;344:353-356. (Pubitemid 24248205)
27. Schupf N, Kapell D, Nightingale B, Lee J, Mohlenhoff J, Bewley S, Ottman R, Mayeux R. Specificity of the fivefold increase in AD in mothers of adults with Down syndrome. Neurology 2001;57:979-984. (Pubitemid 32880189)
28. Shields L, Andrews R. Gestational age changes in circulating CD34+ hematopoietic stem/progenitor cells in fetal cord blood. Am J Obstet Gynecol 1998;178:931-937. (Pubitemid 28247165)
29. Tan X, Liao H, Sun L, Okabe M, Xiao Z, Dawe G. Fetal microchimerism in the maternal mouse brain: a novel population of fetal progenitor or stem cells able to cross the blood-brain barrier? Stem Cells 2005; 23:1443-1452. (Pubitemid 41740992)
30. Thomas M, Williamson R, Craft I, Yazdani N, Rodeck C. Y chromosome sequence DNA amplified from peripheral blood of women in early pregnancy. Lancet 1994;343:413-414. (Pubitemid 24049564)
31. Wataganara T, Chen A, LeShane E, Sullivan L, Borgatta L, Bianchi D, Johnson K. Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy. Fertil Steril 2004; 81:638-644. (Pubitemid 38376122)
32. Wilcox A, Weinberg C, O'Connor J, Baird D, Schlatterer J, Canfield R, Armstrong E, Nisula B. Incidence of early loss of pregnancy. N Engl J Med 1988;319:189-194.
33. Yan Z, Lambert N, Guthrie K, Porter A, Loubiere L, Madeleine M, Stevens A, Hermes H, Nelson L. Male microchimerism in women without sons: Quantitative assessment and correlation with pregnancy history. Am J Med 2005;118:899-906. (Pubitemid 41097469)