Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study

Vaccine

Volumn 30, Issue 39, 2012, Pages 5714-5720

  Puig Barbera J ^a,b   Diez Domingo J ^a   Arnedo Pena, A ^b   Ruiz Garcia M ^b   Perez Vilar S ^a   Mico Esparza J L ^c   Belenguer Varea, A ^d   Carratala Munuera C ^e   Gil Guillen V ^e   Schwarz Chavarri, H ^f  

^a Centro Superior de Investigacion en Salud Publica CSISP   (Spain)

^b Centro de Salud Publica de Castellon   (Spain)

^c HOSPITAL ARNAU DE VILANOVA   (Spain)

^d HOSPITAL DE LA RIBERA   (Spain)

^e MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^f Centro de Salud San Blas   (Spain)

Author keywords

Case control studies; Hospitalizations; Humans; Influenza vaccines; Influenza, Human epidemiology; Respiratory syncytial virus infections epidemiology; Reverse transcriptase polymerase chain reaction; Risk factors; Vaccines, Inactivated

Indexed keywords

INFLUENZA VACCINE;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEASONAL INFLUENZA; SPAIN;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; HOSPITALIZATION; HUMANS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SPAIN; VACCINATION; YOUNG ADULT;

EID: 84864947602     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.07.006     Document Type: Article

References (51)

1. Simonsen L., Fukuda K., Schonberger L.B., Cox N.J. The impact of influenza epidemics on hospitalizations. J Infect Dis 2000, 181(3):831-837.
2. Influenza vaccines. WHO position paper. Wkly Epidemiol Rec 2005; 80(33):279-87.
3. Gerdil C. The annual production cycle for influenza vaccine. Vaccine 2003, 21(16):1776-1779.
4. Osterholm M.T., Kelley N.S., Sommer A., Belongia E.A. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis 2011, 12(1):36-44.
5. Carrat F., Flahault A. Influenza vaccine: the challenge of antigenic drift. Vaccine 2007, 25(39-40):6852-6862.
6. Jefferson T. Influenza vaccination: policy versus evidence. BMJ 2006, 333(7574):912-915.
7. Michiels B., Govaerts F., Remmen R., Vermeire E., Coenen S. A systematic review of the evidence on the effectiveness and risks of inactivated influenza vaccines in different target groups. Vaccine 2011, 29(49):9159-9170.
8. Kelly H., Valenciano M. Estimating the effect of influenza vaccines. Lancet Infect Dis 2012, 12(1):5-6.
9. Petrie J.G., Ohmit S.E., Johnson E., Cross R.T., Monto A.S. Efficacy studies of influenza vaccines: effect of end points used and characteristics of vaccine failures. J Infect Dis 2011, 203(9):1309-1315.
10. Puig-Barbera J. 2010-2011 influenza seasonal vaccine, preliminary mid-season effectiveness estimates: reason for concern, confounding or are we following the right track? Euro Surveill 2011;16(11):pii=19821.
11. Belongia E.A., Kieke B.A., Donahue J.G., Greenlee R.T., Balish A., Foust A., et al. Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 season. J Infect Dis 2009, 199(2):159-167.
12. Skowronski D.M., De Serres G., Crowcroft N.S., Janjua N.Z., Boulianne N., Hottes T.S., et al. Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med 2010, 7(4):e1000258.
13. Savulescu C., Valenciano M., de Mateo S., Larrauri A. Estimating the influenza vaccine effectiveness in elderly on a yearly basis using the Spanish influenza surveillance network - pilot case-control studies using different control groups, 2008-2009 season, Spain. Vaccine 2010, 28(16):2903-2907. cycEVA Study Team.
14. Puig-Barberà J., Arnedo-Pena A., Pardo-Serrano F., Tirado-Balaguer M.D., Pérez-Vilar S., Silvestre-Silvestre E., et al. Effectiveness of seasonal 2008-2009, 2009-2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case-control study. Vaccine 2010, 28(47):7460-7467.
15. Kelly H., Jacoby P., Dixon G.A., Carcione D., Williams S., Moore H.C., et al. Vaccine effectiveness against laboratory-confirmed influenza in healthy young children: a case-control study. Pediatr Infect Dis J 2010, 30(2):107-111.
16. Talbot H.K., Griffin M.R., Chen Q., Zhu Y., Williams J.V., Edwards K.M. Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. J Infect Dis 2011, 203(4):500-508.
17. Cheng A.C., Kotsimbos T., Kelly H.A., Irving L.B., Bowler S.D., Brown S.G., et al. Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study. Vaccine 2011, 29(43):7320-7325.
18. Castilla J., Martínez-Artola V., Salcedo E., Martínez-Baz I., Cenoz M.G., Guevara M., et al. Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: cohort and case-control study. Vaccine 2012, 30(2):195-200.
19. McCarthy N., Giesecke J. Case-case comparisons to study causation of common infectious diseases. Int J Epidemiol 1999, 28(4):764-768.
20. Recommended viruses for influenza vaccines for use in the 2010-2011 northern hemisphere influenza season. Wkly Epidemiol Rec 2010; 85(10):81-92.
21. Influenza Surveillance Influenza case definition. ECDC. Available: [accessed 28.09.11]. http://ecdc.europa.eu/en/activities/surveillance/EISN/surveillance/Pages/influenza_case_definitions.aspx.
22. He J., Bose M.E., Beck E.T., Fan J., Tiwari S., Metallo J., et al. Rapid multiplex reverse transcription-PCR typing of influenza A and B virus, and subtyping of influenza A virus into H1, 2, 3, 5, 7, 9, N1 (human), N1 (animal), N2, and N7, including typing of novel swine origin influenza A (H1N1) virus, during the 2009 outbreak in Milwaukee, Wisconsin. J Clin Microbiol 2009, 47(9):2772-2778.
23. Suwannakarn K., Payungporn S., Chieochansin T., Samransamruajkit R., Amonsin A., Songserm T., et al. Typing (A/B) and subtyping (H1/H3/H5) of influenza A viruses by multiplex real-time RT-PCR assays. J Virol Methods 2008, 152(1-2):25-31.
24. Kuypers J., Martin E.T., Heugel J., Wright N., Morrow R., Englund J.A. Clinical disease in children associated with newly described coronavirus subtypes. Pediatrics 2007, 119(1):e70-e76.
25. Matsuzaki Y., Takashita E., Okamoto M., Mizuta K., Itagaki T., Katsushima F., et al. Evaluation of a new rapid antigen test using immunochromatography for detection of human metapneumovirus in comparison with real-time PCR assay. J Clin Microbiol 2009, 47(9):2981-2984.
26. Neske F., Blessing K., Tollmann F., Schubert J., Rethwilm A., Kreth H.W., et al. Real-time PCR for diagnosis of human bocavirus infections and phylogenetic analysis. J Clin Microbiol 2007, 45(7):2116-2122.
27. van de Pol A.C., van Loon A.M., Wolfs T.F., Jansen N.J., Nijhuis M., Breteler E.K., et al. Increased detection of respiratory syncytial virus, influenza viruses, parainfluenza viruses, and adenoviruses with real-time PCR in samples from patients with respiratory symptoms. J Clin Microbiol 2007, 45(7):2260-2262.
28. Tapparel C., Cordey S., Van Belle S., Turin L., Lee W.M., Regamey N., et al. New molecular detection tools adapted to emerging rhinoviruses and enteroviruses. J Clin Microbiol 2009, 47(6):1742-1749.
29. Puig-Barberà J., Diez-Domingo J., Pérez Hoyos S., Belenguer Varea A., González Vidal D. Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. Vaccine 2004, 23(3):283-289.
30. Domingo-Salvany A., Regidor E., Alonso J., Alvarez-Dardet C. Proposal for a social class measure, Working Group of the Spanish Society of Epidemiology and the Spanish Society of Family and Community Medicine. Aten Primaria 2000, 25(5):350-363.
31. Miettinen O.S. Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol 1974, 99(5):325-332.
32. Pearce N. What does the odds ratio estimate in a case-control study?. Int J Epidemiol 1993, 22(6):1189-1192.
33. Jefferson T., Di Pietrantonj C., Al-Ansary L.A., Ferroni E., Thorning S., Thomas R.E. Vaccines for preventing influenza in the elderly. Cochrane Database Syst Rev 2010, 2(2):CD004876.
34. Govaert T.M., Thijs C.T., Masurel N., Sprenger M.J., Dinant G.J., Knottnerus J.A. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA 1994, 272(21):1661-1665.
35. Kissling E., Valenciano M., Falcao J., Larrauri A., Widgren K., Pitigoi D., et al. I-MOVE towards monitoring seasonal and pandemic influenza vaccine effectiveness: lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9. Euro Surveill 2009, 14(44).
36. Community Network of Reference Laboratories (CNRL) for Human Influenza in Europe. Influenza virus characterisation, summary Europe, March 2011. ECDC and Community Network of Reference Laboratories (CNRL) for Human Influenza in Europe; 13 April 2011. Available: [accessed 26.02.12]. http://ecdc.europa.eu/en/publications/Publications/1304_Influenza_virus_characterisation_2011_April.pdf.
37. Irving S.A., Donahue J.G., Shay D.K., Ellis-Coyle T.L., Belongia E.A. Evaluation of self-reported and registry-based influenza vaccination status in a Wisconsin cohort. Vaccine 2009, 27(47):6546-6549.
38. Puig-Barberà J, Pérez-Vilar S, Pérez-Breva L, Alemán-Sánchez S, Morant-Talamante N, Martínez-úbeda S, et al. Validez del registro de vacunas nominal para conocer el estado de vacunación frente a la gripe en adultos ingresados en hospitales de la comunidad valenciana. 6° Congreso de la Asociación Española de Vacunología (AEV). Santiago de Compostela, España, 23-26 November 2011. (P 34).
39. Hook E.B., Regal R.R. Capture-recapture methods in epidemiology: methods and limitations. Epidemiol Rev 1995, 17(2):243-264.
40. Lee N., Chan P.K., Hui D.S., Rainer T.H., Wong E., Choi K.W., et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. J Infect Dis 2009, 200(4):492-500.
41. Zambon M. Laboratory diagnosis of influenza. Textbook of influenza 1998, 291-313. Blackwell Science, Oxford. K.J. Nicholson, R.G. Webster, J. Hay (Eds.).
42. Abu-Diab A., Azzeh M., Ghneim R., Ghneim R., Zoughbi M., Turkuman S., et al. Comparison between pernasal flocked swabs and nasopharyngeal aspirates for detection of common respiratory viruses in samples from children. J Clin Microbiol 2008, 46(7):2414-2417.
43. Falsey A.R., Hennessey P.A., Formica M.A., Cox C., Walsh E.E. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005, 352(17):1749-1759.
44. Walsh E.E., Peterson D.R., Falsey A.R. Human metapneumovirus infections in adults: another piece of the puzzle. Arch Intern Med 2008, 168(22):2489-2496.
45. Talbot H.K., Falsey A.R. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis 2010, 50(5):747-751.
46. Valenciano M., Kissling E., Cohen J.M., Oroszi B., Barret A.S., Rizzo C., et al. Estimates of pandemic influenza vaccine effectiveness in Europe, 2009-2010: results of influenza monitoring vaccine effectiveness in Europe (I-MOVE) multicentre case-control study. PLoS Med 2011, 8(1):2424-2435.
47. Delgado C., Jiménez-Jorge S., Ledesma J., Pozo F., León I., de Mateo S., Larrauri A Vigilancia de la gripe en España, Temporada 2010-11. (Desde la semana 40/2010 hasta la semana 20/2011). Boletín Epidemiológico Semanal (BES) 2011, 19(Semanas 28-29):117-130.
48. Miller E., Hoschler K., Hardelid P., Stanford E., Andrews N., Zambon M. Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet 2010, 375(9720):1100-1108.
49. Chen H., Wang Y., Liu W., Zhang J., Dong B., Fan X., et al. Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerg Infect Dis 2009, 15(11):1849-1850.
50. Ikonen N., Strengell M., Kinnunen L., Osterlund P., Pirhonen J., Broman M., et al. High frequency of cross-reacting antibodies against 2009 pandemic influenza A (H1N1) virus among the elderly in Finland. Euro Surveill 2010, 15(5). pii: 19478.
51. Greenbaum J.A., Kotturi M.F., Kim Y., Oseroff C., Vaughan K., Salimi N., et al. Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population. Proc Natl Acad Sci U S A 2009, 106(48):20365-20370.