Neuronal Correlates of Metacognition in Primate Frontal Cortex

Neuron

Volumn 75, Issue 3, 2012, Pages 517-530

  Middlebrooks, Paul G ^a,b,c   Sommer, Marc A ^a,b,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; BRAIN NERVE CELL; COGNITION; DECISION MAKING; FRONTAL CORTEX; FRONTAL EYE FIELD; MACACA MULATTA; MALE; MENTAL TASK; METACOGNITION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SUPPLEMENTARY EYE FIELD;

ANIMALS; COGNITION; ELECTROPHYSIOLOGY; FRONTAL LOBE; MACACA MULATTA; MALE; NEURONS; PSYCHOMOTOR PERFORMANCE;

EID: 84864934073     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.05.028     Document Type: Article

References (66)

1. Anderson E.B., Mitchell J.F., Reynolds J.H. Attentional modulation of firing rate varies with burstiness across putative pyramidal neurons in macaque visual area V4. J. Neurosci. 2011, 31:10983-10992.
2. Barraclough D.J., Conroy M.L., Lee D. Prefrontal cortex and decision making in a mixed-strategy game. Nat. Neurosci. 2004, 7:404-410.
3. Boch R.A., Goldberg M.E. Participation of prefrontal neurons in the preparation of visually guided eye movements in the rhesus monkey. J. Neurophysiol. 1989, 61:1064-1084.
4. Bruce C.J., Goldberg M.E. Primate frontal eye fields. I. Single neurons discharging before saccades. J. Neurophysiol. 1985, 53:603-635.
5. Call J. Do apes know that they could be wrong?. Anim. Cogn. 2010, 13:689-700.
6. Chua E.F., Schacter D.L., Rand-Giovannetti E., Sperling R.A. Understanding metamemory: neural correlates of the cognitive process and subjective level of confidence in recognition memory. Neuroimage 2006, 29:1150-1160.
7. Connors B.W., Gutnick M.J. Intrinsic firing patterns of diverse neocortical neurons. Trends Neurosci. 1990, 13:99-104.
8. Constantinidis C., Goldman-Rakic P.S. Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex. J. Neurophysiol. 2002, 88:3487-3497.
9. Crapse T.B., Sommer M.A. Corollary discharge across the animal kingdom. Nat. Rev. Neurosci. 2008, 9:587-600.
10. Ding L., Hikosaka O. Comparison of reward modulation in the frontal eye field and caudate of the macaque. J. Neurosci. 2006, 26:6695-6703.
11. Flavell J.H. Metacognitive aspects of problem solving. The Nature of Intelligence 1976, 231-236. Erlbaum, Hillsdale, NJ. L.B. Resnick (Ed.).
12. Foote A.L., Crystal J.D. Metacognition in the rat. Curr. Biol. 2007, 17:551-555.
13. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J. Neurophysiol. 1989, 61:331-349.
14. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms. J. Neurophysiol. 1990, 63:814-831.
15. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex. J. Neurophysiol. 1991, 65:1464-1483.
16. Hampton R.R. Rhesus monkeys know when they remember. Proc. Natl. Acad. Sci. USA 2001, 98:5359-5362.
17. Hampton R.R., Zivin A., Murray E.A. Rhesus monkeys (Macaca mulatta) discriminate between knowing and not knowing and collect information as needed before acting. Anim. Cogn. 2004, 7:239-246.
18. Hays, A.V., Richmond, B.J., and Optican, L. (1982). A UNIX-based multiple process system for real-time data acquisition and control. WESCON Conference Proceedings, 2, 1-10.
19. Iba M., Sawaguchi T. Involvement of the dorsolateral prefrontal cortex of monkeys in visuospatial target selection. J. Neurophysiol. 2003, 89:587-599.
20. Johnston K., Everling S. Neural activity in monkey prefrontal cortex is modulated by task context and behavioral instruction during delayed-match-to-sample and conditional prosaccade-antisaccade tasks. J. Cogn. Neurosci. 2006, 18:749-765.
21. Kepecs A., Uchida N., Zariwala H.A., Mainen Z.F. Neural correlates, computation and behavioural impact of decision confidence. Nature 2008, 455:227-231.
22. Kiani R., Shadlen M.N. Representation of confidence associated with a decision by neurons in the parietal cortex. Science 2009, 324:759-764.
23. Kikyo H., Ohki K., Miyashita Y. Neural correlates for feeling-of-knowing: an fMRI parametric analysis. Neuron 2002, 36:177-186.
24. Kim J.N., Shadlen M.N. Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque. Nat. Neurosci. 1999, 2:176-185.
25. Kim S., Hwang J., Lee D. Prefrontal coding of temporally discounted values during intertemporal choice. Neuron 2008, 59:161-172.
26. Kornell N., Son L.K., Terrace H.S. Transfer of metacognitive skills and hint seeking in monkeys. Psychol. Sci. 2007, 18:64-71.
27. Mays L.E., Sparks D.L. Saccades are spatially, not retinocentrically, coded. Science 1980, 208:1163-1165.
28. McCoy A.N., Platt M.L. Expectations and outcomes: decision-making in the primate brain. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 2005, 191:201-211.
29. Middlebrooks P.G., Sommer M.A. Metacognition in monkeys during an oculomotor task. J. Exp. Psychol. Learn. Mem. Cogn. 2011, 37:325-337.
30. Miller E.K., Cohen J.D. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 2001, 24:167-202.
31. Mitchell J.F., Sundberg K.A., Reynolds J.H. Differential attention-dependent response modulation across cell classes in macaque visual area V4. Neuron 2007, 55:131-141.
32. Mohler C.W., Goldberg M.E., Wurtz R.H. Visual receptive fields of frontal eye field neurons. Brain Res. 1973, 61:385-389.
33. Nakamura K., Roesch M.R., Olson C.R. Neuronal activity in macaque SEF and ACC during performance of tasks involving conflict. J. Neurophysiol. 2005, 93:884-908.
34. Nelson T.O. Consciousness and metacognition. Am. Psychol. 1996, 51:102-116.
35. Nelson T.O., Narens L. Metamemory: a theoretical framework and new findings. Psychol. Learn. Motiv. 1990, 26:125-173.
36. Pannu J.K., Kaszniak A.W., Rapcsak S.Z. Metamemory for faces following frontal lobe damage. J. Int. Neuropsychol. Soc. 2005, 11:668-676.
37. Pouget P., Emeric E.E., Stuphorn V., Reis K., Schall J.D. Chronometry of visual responses in frontal eye field, supplementary eye field, and anterior cingulate cortex. J. Neurophysiol. 2005, 94:2086-2092.
38. Reder L.M., Schunn C.D. Metacognition does not imply awareness: strategy choice is governed by implicit learning and memory. Implicit Memory and Metacognition 1996, 45-77. Lawrence Erlbaum Associates, Mahwah, NJ. L.M. Reder (Ed.).
39. Roesch M.R., Olson C.R. Impact of expected reward on neuronal activity in prefrontal cortex, frontal and supplementary eye fields and premotor cortex. J. Neurophysiol. 2003, 90:1766-1789.
40. Romanski L.M. Domain specificity in the primate prefrontal cortex. Cogn. Affect. Behav. Neurosci. 2004, 4:421-429.
41. Rounis E., Maniscalco B., Rothwell J.C., Passingham R.E., Lau H. Theta-burst transcranial magnetic stimulation to the prefrontal cortex impairs metacognitive visual awareness. Cogn. Neurosci. 2010, 1:165-175.
42. Russo G.S., Bruce C.J. Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system. J. Neurophysiol. 1996, 76:825-848.
43. Sato T.R., Schall J.D. Effects of stimulus-response compatibility on neural selection in frontal eye field. Neuron 2003, 38:637-648.
44. Schall J.D. Neural basis of deciding, choosing and acting. Nat. Rev. Neurosci. 2001, 2:33-42.
45. Schall J.D., Thompson K.G. Neural selection and control of visually guided eye movements. Annu. Rev. Neurosci. 1999, 22:241-259.
46. Schall J.D., Hanes D.P., Thompson K.G., King D.J. Saccade target selection in frontal eye field of macaque. I. Visual and premovement activation. J. Neurosci. 1995, 15:6905-6918.
47. Schlag J., Schlag-Rey M. Evidence for a supplementary eye field. J. Neurophysiol. 1987, 57:179-200.
48. Schnyer D.M., Verfaellie M., Alexander M.P., LaFleche G., Nicholls L., Kaszniak A.W. A role for right medial prefontal cortex in accurate feeling-of-knowing judgements: evidence from patients with lesions to frontal cortex. Neuropsychologia 2004, 42:957-966.
49. Seo H., Lee D. Behavioral and neural changes after gains and losses of conditioned reinforcers. J. Neurosci. 2009, 29:3627-3641.
50. Shields W.E., Smith J.D., Guttmannova K., Washburn D.A. Confidence judgments by humans and rhesus monkeys. J. Gen. Psychol. 2005, 132:165-186.
51. Smith J.D., Schull J., Strote J., McGee K., Egnor R., Erb L. The uncertain response in the bottlenosed dolphin (Tursiops truncatus). J. Exp. Psychol. Gen. 1995, 124:391-408.
52. Smith J.D., Shields W.E., Allendoerfer K.R., Washburn D.A. Memory monitoring by animals and humans. J. Exp. Psychol. Gen. 1998, 127:227-250.
53. So N.Y., Stuphorn V. Supplementary eye field encodes option and action value for saccades with variable reward. J. Neurophysiol. 2010, 104:2634-2653.
54. So N.Y., Stuphorn V. Supplementary eye field encodes reward prediction error. J. Neurosci. 2012, 32:2950-2963.
55. Sommer M.A., Wurtz R.H. Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. J. Neurophysiol. 2000, 83:1979-2001.
56. Sommer M.A., Wurtz R.H. Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus. J. Neurophysiol. 2001, 85:1673-1685.
57. Sommer M.A., Wurtz R.H. What the brain stem tells the frontal cortex. I. Oculomotor signals sent from superior colliculus to frontal eye field via mediodorsal thalamus. J. Neurophysiol. 2004, 91:1381-1402.
58. Stuphorn V., Taylor T.L., Schall J.D. Performance monitoring by the supplementary eye field. Nature 2000, 408:857-860.
59. Suda-King C. Do orangutans (Pongo pygmaeus) know when they do not remember?. Anim. Cogn. 2008, 11:21-42.
60. Sutton R.S., Barto A.G. Reinforcement Learning 1998, Volume 9. MIT Press, Cambridge, MA.
61. Tanji J., Hoshi E. Role of the lateral prefrontal cortex in executive behavioral control. Physiol. Rev. 2008, 88:37-57.
62. Thompson K.G., Schall J.D. The detection of visual signals by macaque frontal eye field during masking. Nat. Neurosci. 1999, 2:283-288.
63. Thompson K.G., Bichot N.P. A visual salience map in the primate frontal eye field. Prog. Brain Res. 2005, 147:251-262.
64. Wallis J.D., Miller E.K. From rule to response: neuronal processes in the premotor and prefrontal cortex. J. Neurophysiol. 2003, 90:1790-1806.
65. Watanabe M. Reward expectancy in primate prefrontal neurons. Nature 1996, 382:629-632.
66. Zar J.H. Biostatistical Analysis 1999, Prentice Hall, New Jersey.