-
1
-
-
77957366667
-
Biomarkers as predictors of response to treatment with motesanib in patients with progressive advanced thyroid cancer
-
Bass MB, Sherman SI, Schlumberger MJ, Davis MT, Kivman L, Khoo HM, Notari KH, Peach M, Hei YJ, Patterson SD (2010) Biomarkers as predictors of response to treatment with motesanib in patients with progressive advanced thyroid cancer. J Clin Endocrinol Metab 95: 5018-5027
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 5018-5027
-
-
Bass, M.B.1
Sherman, S.I.2
Schlumberger, M.J.3
Davis, M.T.4
Kivman, L.5
Khoo, H.M.6
Notari, K.H.7
Peach, M.8
Hei, Y.J.9
Patterson, S.D.10
-
2
-
-
70249101414
-
Efficacy and safety of trabectidin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
-
Demetri GD, Chawla SP, von Mehren M, Ritch P, Baker LH, Blay JY, Hande KR, Keohan ML, Samuels BL, Schuetze S, Lebedinsky C, Elsayed YA, Izquierdo MA, Gomez J, Park YC, Le Cesne A (2009) Efficacy and safety of trabectidin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. J Clin Oncol 27: 4188-4196
-
(2009)
J Clin Oncol
, vol.27
, pp. 4188-4196
-
-
Demetri, G.D.1
Chawla, S.P.2
Von Mehren, M.3
Ritch, P.4
Baker, L.H.5
Blay, J.Y.6
Hande, K.R.7
Keohan, M.L.8
Samuels, B.L.9
Schuetze, S.10
Lebedinsky, C.11
Elsayed, Y.A.12
Izquierdo, M.A.13
Gomez, J.14
Park, Y.C.15
Le Cesne, A.16
-
3
-
-
20944441692
-
Soluble markers for the assessment of biological activity with PTK787/ZK222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase i trials
-
Drevs J, Zirrgiebel U, Schmidt-Gersbach CI, Mross K, Medinger M, Lee L, Pinheiro J, Wood J, Thomas AL, Unger C, Henry A, Steward WP, Laurent D, Lebwohl D, Dugan M, Marme D (2005) Soluble markers for the assessment of biological activity with PTK787/ZK222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol 16: 558-565
-
(2005)
Ann Oncol
, vol.16
, pp. 558-565
-
-
Drevs, J.1
Zirrgiebel, U.2
Schmidt-Gersbach, C.I.3
Mross, K.4
Medinger, M.5
Lee, L.6
Pinheiro, J.7
Wood, J.8
Thomas, A.L.9
Unger, C.10
Henry, A.11
Steward, W.P.12
Laurent, D.13
Lebwohl, D.14
Dugan, M.15
Marme, D.16
-
4
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumorindependent and correlate with antitumor efficacy
-
Ebos JM, Lee CR, Christensen JG, Mutsaerts AJ, Kerbel RS (2007) Multiple circulating proangiogenic factors induced by sunitinib malate are tumorindependent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 104: 17069-17074
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaerts, A.J.4
Kerbel, R.S.5
-
5
-
-
0033571557
-
Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face
-
Fata F, O'Reilly E, Ilson D, Pfister D, Leffel D, Kelsen DP, Schwartz GK, Casper ES (1999) Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face. Cancer 86: 2034-2037
-
(1999)
Cancer
, vol.86
, pp. 2034-2037
-
-
Fata, F.1
O'Reilly, E.2
Ilson, D.3
Pfister, D.4
Leffel, D.5
Kelsen, D.P.6
Schwartz, G.K.7
Casper, E.S.8
-
6
-
-
56749174211
-
FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy?
-
Fischer C, Mazzone M, Jonckx B, Carmeliet P (2008) FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nat Rev Cancer 8: 942-956
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 942-956
-
-
Fischer, C.1
Mazzone, M.2
Jonckx, B.3
Carmeliet, P.4
-
7
-
-
77954987954
-
(Pre) clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor
-
Hamberg P, Verweij J, Sleijfer S (2010) (Pre)clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor. Oncologist 15: 539-547
-
(2010)
Oncologist
, vol.15
, pp. 539-547
-
-
Hamberg, P.1
Verweij, J.2
Sleijfer, S.3
-
8
-
-
74949090109
-
Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small cell lung cancer
-
Hanrahan EO, Lin HY, Kim ES, Yan S, Du DZ, McKee KS, Tran HT, Lee JJ, Ryan AJ, Langmuir P, Johnson BE, Heymach JV (2009a) Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small cell lung cancer. J Clin Oncol 28: 193-201
-
(2009)
J Clin Oncol
, vol.28
, pp. 193-201
-
-
Hanrahan, E.O.1
Lin, H.Y.2
Kim, E.S.3
Yan, S.4
Du, D.Z.5
McKee, K.S.6
Tran, H.T.7
Lee, J.J.8
Ryan, A.J.9
Langmuir, P.10
Johnson, B.E.11
Heymach, J.V.12
-
9
-
-
66149188254
-
Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small lung cancer
-
Hanrahan EO, Ryan AJ, Mann H, Kennedy SJ, Langmuir P, Natale RB, Herbst RS, Johnson BE, Heymach JV (2009b) Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small lung cancer. Clin Cancer Res 15: 3600-3609
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3600-3609
-
-
Hanrahan, E.O.1
Ryan, A.J.2
Mann, H.3
Kennedy, S.J.4
Langmuir, P.5
Natale, R.B.6
Herbst, R.S.7
Johnson, B.E.8
Heymach, J.V.9
-
10
-
-
41749097667
-
A randomized, double-blind, phase IIa dose-finding study of vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
-
Kiura K, Nakagawa K, Shinkai T, Eguchi K, Ohe Y, Yamamoto N, Tsuboi M, Yokota S, Seto T, Jiang H, Nishio K, Saijo N, Fukuoka M (2008) A randomized, double-blind, phase IIa dose-finding study of vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. J Thorac Oncol 3: 386-393
-
(2008)
J Thorac Oncol
, vol.3
, pp. 386-393
-
-
Kiura, K.1
Nakagawa, K.2
Shinkai, T.3
Eguchi, K.4
Ohe, Y.5
Yamamoto, N.6
Tsuboi, M.7
Yokota, S.8
Seto, T.9
Jiang, H.10
Nishio, K.11
Saijo, N.12
Fukuoka, M.13
-
11
-
-
74249092481
-
Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
-
Murukesh N, Dive C, Jayson GC (2010) Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer 102: 8-18
-
(2010)
Br J Cancer
, vol.102
, pp. 8-18
-
-
Murukesh, N.1
Dive, C.2
Jayson, G.C.3
-
12
-
-
77950243445
-
Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib
-
Nikolanikos PG, Altorki N, Yankelevitz D, Tran HT, Yan S, Rajagopalan D, Bordogna W, Ottesen LH, Heymach JV (2010) Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib. Cancer Res 70: 2171-2179
-
(2010)
Cancer Res
, vol.70
, pp. 2171-2179
-
-
Nikolanikos, P.G.1
Altorki, N.2
Yankelevitz, D.3
Tran, H.T.4
Yan, S.5
Rajagopalan, D.6
Bordogna, W.7
Ottesen, L.H.8
Heymach, J.V.9
-
13
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ (2008) Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 26: 3743-3748
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
Hutson, T.E.7
Margolin, K.8
Harmon, C.S.9
Deprimo, S.E.10
Kim, S.T.11
Chen, I.12
George, D.J.13
-
14
-
-
34347235531
-
Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
-
Rosen LS, Kurzrock R, Mulay M, Van Vugt A, Purdom M, Ng C, Silverman J, Koutsoukos A, Sun YN, Bass MB, Xu RY, Polverino A, Wiezorek JS, Chang DD, Benjamin R, Herbst RS (2007) Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 25: 2369-2376
-
(2007)
J Clin Oncol
, vol.25
, pp. 2369-2376
-
-
Rosen, L.S.1
Kurzrock, R.2
Mulay, M.3
Van Vugt, A.4
Purdom, M.5
Ng, C.6
Silverman, J.7
Koutsoukos, A.8
Sun, Y.N.9
Bass, M.B.10
Xu, R.Y.11
Polverino, A.12
Wiezorek, J.S.13
Chang, D.D.14
Benjamin, R.15
Herbst, R.S.16
-
15
-
-
67650337802
-
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European Organisation for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma group (EORTC 62043)
-
Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schöffski P, Collin F, Pandite L, Marreaud S, De Brauwer A, van Glabbeke M, Verweij J, Blay JY (2009) Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma group (EORTC 62043). J Clin Oncol 27: 3126-3132
-
(2009)
J Clin Oncol
, vol.27
, pp. 3126-3132
-
-
Sleijfer, S.1
Ray-Coquard, I.2
Papai, Z.3
Le Cesne, A.4
Scurr, M.5
Schöffski, P.6
Collin, F.7
Pandite, L.8
Marreaud, S.9
De Brauwer, A.10
Van Glabbeke, M.11
Verweij, J.12
Blay, J.Y.13
-
16
-
-
31444432831
-
Using single-agent therapy in adult patients with advanced soft tissue sarcoma can still be considered standard care
-
Sleijfer S, Seynaeve C, Verweij J (2005) Using single-agent therapy in adult patients with advanced soft tissue sarcoma can still be considered standard care. Oncologist 10: 833-841
-
(2005)
Oncologist
, vol.10
, pp. 833-841
-
-
Sleijfer, S.1
Seynaeve, C.2
Verweij, J.3
-
17
-
-
36849015252
-
The pharmacologic basis of ifosfamide use in adult patients with advanced soft tissue sarcomas
-
Tascilar M, Loos WJ, Seynaeve C, Verweij J, Sleijfer S (2007) The pharmacologic basis of ifosfamide use in adult patients with advanced soft tissue sarcomas. Oncologist 12: 1351-1360
-
(2007)
Oncologist
, vol.12
, pp. 1351-1360
-
-
Tascilar, M.1
Loos, W.J.2
Seynaeve, C.3
Verweij, J.4
Sleijfer, S.5
-
18
-
-
79960364265
-
Use of multiplatform analysis of plasma cytokines and angiogenic factors (CAFs) to identify baseline CAFs associated with pazopanib response and tumor burden in renal cell carcinoma (RCC) patients
-
abstr 4522
-
Tran HT, Liu Y, Lin Y, Martin A-M, Baker KL, Fritsche HA, Zurita A, Pandite LN, Heymach JV (2010) Use of multiplatform analysis of plasma cytokines and angiogenic factors (CAFs) to identify baseline CAFs associated with pazopanib response and tumor burden in renal cell carcinoma (RCC) patients. J Clin Oncol 28 (suppl 15s): abstr 4522
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 15S
-
-
Tran, H.T.1
Liu, Y.2
Lin, Y.3
Martin, A.-M.4
Baker, K.L.5
Fritsche, H.A.6
Zurita, A.7
Pandite, L.N.8
Heymach, J.V.9
-
19
-
-
80355141438
-
PALETTE: A randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy-an EORTC STBSG Global Network Study (EORTC 62072
-
abstr LBA10002
-
Van der Graaf WT, Blay JY, Chawla SP, Kim D, Bui Nguyen B, Casali PG, Schöffski P, Aglietta M, Staddon AP, Beppu Y, Le Cesne A, Gelderblom H, Judson IR, Araki N, Ouali M, Marreaud S, Hodge R, Dewji M, Dei Tos AP, Hohenberger P (2011) PALETTE: a randomized, double-blind, phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy-an EORTC STBSG Global Network Study (EORTC 62072). J Clin Oncol 29 (suppl): abstr LBA10002
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Van Der Graaf, W.T.1
Blay, J.Y.2
Chawla, S.P.3
Kim, D.4
Bui Nguyen, B.5
Casali, P.G.6
Schöffski, P.7
Aglietta, M.8
Staddon, A.P.9
Beppu, Y.10
Le Cesne, A.11
Gelderblom, H.12
Judson, I.R.13
Araki, N.14
Ouali, M.15
Marreaud, S.16
Hodge, R.17
Dewji, M.18
Dei Tos, A.P.19
Hohenberger, P.20
more..
-
20
-
-
20844433223
-
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: A randomised trial
-
Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY, Issels R, van Oosterom A, Hogendoorn PC, Van Glabbeke M, Bertulli R, Judson I (2004) Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: a randomised trial. Lancet 364: 1127-1134
-
(2004)
Lancet
, vol.364
, pp. 1127-1134
-
-
Verweij, J.1
Casali, P.G.2
Zalcberg, J.3
Lecesne, A.4
Reichardt, P.5
Blay, J.Y.6
Issels, R.7
Van Oosterom, A.8
Hogendoorn, P.C.9
Van Glabbeke, M.10
Bertulli, R.11
Judson, I.12
|