Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: The HERITAGE Family Study

European Journal of Applied Physiology

Volumn 112, Issue 8, 2012, Pages 2969-2978

  Rice, Treva K ^a   Sarzynski, Mark A ^b   Sung, Yun Ju ^a   Argyropoulos, George ^b   Stütz, Adrian M ^b   Teran Garcia, Margarita ^b   Rao, D C ^a   Bouchard, Claude ^b   Rankinen, Tuomo ^b  

^a WASHINGTON UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Fitness; Genetics; MIPEP; SGCG; SNP

Indexed keywords

ARTICLE; CAUCASIAN; CHROMOSOME 13; CLINICAL TRIAL; EXERCISE TEST; EXERCISE TOLERANCE; GENETIC ASSOCIATION; GENETICS; HAPLOTYPE; HEART OUTPUT; HEREDITY; HUMAN; MULTICENTER STUDY; OXYGEN CONSUMPTION; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TIME; UNITED STATES;

CARDIAC OUTPUT; CHROMOSOMES, HUMAN, PAIR 13; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXERCISE TEST; EXERCISE TOLERANCE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HEREDITY; HUMANS; OXYGEN CONSUMPTION; PEDIGREE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; REGRESSION ANALYSIS; TIME FACTORS; UNITED STATES;

EID: 84864876766     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2274-8     Document Type: Article

References (34)

1. Abecasis GR, Cardon LR, Cookson WO (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292 (Pubitemid 30481489)
2. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlinrapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101
3. Anney RJ, Lasky-Su J, O'Dushlaine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vasquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (2008) Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Am J Med Genet B Neuropsychiatr Genet 147B:1369-1378
4. Barresi R, Moore SA, Stolle CA, Mendell JR, Campbell KP (2000) Expression of gamma-sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex. J Biol Chem 275:38554-38560 (Pubitemid 32009183)
5. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265 (Pubitemid 40202029)
6. Blair SN, Kampert JB, Kohl HW, Barlow CE, Macera CA, Paffenbar-ger RS, Gibbons LW (1996) InXuences of cardiorespiratory Wt-ness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 276:205-210 (Pubitemid 26235064)
7. Bouchard C, Dionne FT, Simoneau JA, Boulay MR (1992) Genetics of aerobic and anaerobic performances. Exerc Sport Sci Rev 20: 27-58
8. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J (1995) The HERITAGE family study. Aims, design, and measurement protocol. Med Sci Sports Exerc 27:721-729
9. Chagnon YC, Borecki IB, Perusse L, Roy S, Lacaille M, Chagnon M, Ho-Kim MA, Rice T, Province MA, Rao DC, Bouchard C (2000) Genome-wide search for genes related to the fat-free body mass in the Quebec family study. Metabolism 49:203-207 (Pubitemid 30090884)
10. Chew A, Buck EA, Peretz S, Sirugo G, Rinaldo P, Isaya G (1997) Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP). Genomics 40:493-496 (Pubitemid 27137004)
11. Chew A, Sirugo G, Alsobrook JP II, Isaya G (2000) Functional and genomic analysis of the human mitochondrial intermediate peptidase, a putative protein partner of frataxin. Genomics 65:104-112 (Pubitemid 30314417)
12. Collier CR (1956) Determination of mixed venous CO2 tensions by rebreathing. J Appl Physiol 9:25-29
13. Cornelissen VA, Arnout J, Holvoet P, Fagard RH (2009) Influence of exercise at lower and higher intensity on blood pressure and cardiovascular risk factors at older age. J Hypertens 27:753-762
14. Crosbie RH, Lim LE, Moore SA, Hirano M, Hays AP, Maybaum SW, Collin H, Dovico SA, Stolle CA, Fardeau M, Tome FM, Campbell KP (2000) Molecular and genetic characterization of sarco-span: Insights into sarcoglycan-sarcospan interactions. Hum Mol Genet 9:2019-2027
15. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D (2005) Efficiency and power in genetic association studies. Nat Genet 37(11):1217-1223 (Pubitemid 41568704)
16. Durbeej M, Campbell KP (1999) Biochemical characterization of the epithelial dystroglycan complex. J Biol Chem 274:26609-26616
17. Fulker DW, Cherny SS, Sham PC, Hewitt JK (1999) Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64:259-267 (Pubitemid 30428979)
18. Hagberg JM, Rankinen T, Loos RJ, Perusse L, Roth SM, Wolfarth B, Bouchard C (2011) Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exerc 43:743-752
19. Lander ES, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199
20. Larson EB, Bruce RA (1987) Health beneWts of exercise in an aging society. Arch Intern Med 147:353-356 (Pubitemid 17040261)
21. Mendoza SG, Carrasco H, Zerpa A, Briceno Y, Rodriguez F, Speirs J, Glueck CJ (1991) Effect of physical training on lipids, lipoproteins, apolipoproteins, lipases, and endogenous sex hormones in men with premature myocardial infarction. Metabolism 40: 368-377
22. Noguchi S, McNally EM, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida M, Yamamoto H, Bonnemann CG, Gussoni E, Denton PH, Kyriakides T, Middleton L, Hentati F, Ben Hamida M, Nonaka I, Vance JM, Kunkel LM, Ozawa E (1995) Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science 270:819-822
23. Perusse L, Gagnon J, Province MA, Rao DC, Wilmore JH, Leon AS, Bouchard C, Skinner JS (2001) Familial aggregation of submaximal aerobic performance in the HERITAGE Family study. Med Sci Sports Exerc 33:597-604 (Pubitemid 32274152)
24. Physical Activity Guidelines Advisory Committee (2008) Physical activity guidelines advisory committee report. Department of Health and Human Services, Washington, DC
25. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575 (Pubitemid 47330214)
26. Sham PC, Purcell S, Cherny SS, Abecasis GR (2002) Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet 71:238-253 (Pubitemid 34800241)
27. Skinner JS, Wilmore KM, Krasnoff JB, Jaskolski A, Jaskolska A, Gagnon J, Province MA, Leon AS, Rao DC, Wilmore JH, Bouchard C (2000) Adaptation to a standardized training program and changes in Wtness in a large, heterogeneous population: The HERITAGE Family Study. Med Sci Sports Exerc 32:157-161 (Pubitemid 30056972)
28. Todorova A, Tournev I, Ninova N, Georgieva V, Kremensky I (2002) Screening for C283Y gamma-sarcoglycan mutation in a high-risk group of Bulgarian Gypsies: Evidence for a geographical localization and a non-random distribution among Gypsy subgroups. Community Genet 5:217-221 (Pubitemid 35404307)
29. Trabelsi M, Kavian N, Daoud F, Commere V, Deburgrave N, Beugnet C, Llense S, Barbot JC, Vasson A, Kaplan JC, Leturcq F, Chelly J (2008) Revised spectrum of mutations in sarcoglycanopathies. Eur J Hum Genet 16:793-803 (Pubitemid 351865677)
30. US Department of Health and Human Services (1996) Physical activity and health: A report of the Surgeon General. US Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA
31. Wilmore JH, Farrell PA, Norton AC, RWd Cote, Coyle EF, Ewy GA, Temkin LP, Billing JE (1982) An automated, indirect assessment of cardiac output during rest and exercise. J Appl Physiol 52:1493-1497 (Pubitemid 12044337)
32. Wilmore JH, Stanforth PR, Turley KR, Gagnon J, Daw EW, Leon AS, Rao DC, Skinner JS, Bouchard C (1998) Reproducibility of cardiovascular, respiratory, and metabolic responses to submaximal exercise: The HERITAGE Family Study. Med Sci Sports Exerc 30:259-265 (Pubitemid 28095942)
33. Wilmore JH, Stanforth PR, Gagnon J, Rice T, Mandel S, Leon AS, Rao DC, Skinner JS, Bouchard C (2001a) Cardiac output and stroke volume changes with endurance training: The HERITAGE Family Study. Med Sci Sports Exerc 33:99-106 (Pubitemid 32064405)
34. Wilmore JH, Stanforth PR, Gagnon J, Rice T, Mandel S, Leon AS, Rao DC, Skinner JS, Bouchard C (2001b) Heart rate and blood pressure changes with endurance training: The HERITAGE Family Study. Med Sci Sports Exerc 33:107-116 (Pubitemid 32064406)