Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Journal of Lipid Research

Volumn 53, Issue 9, 2012, Pages 1932-1943

  Wang, Yan ^a,b   Huang, Yongcheng ^a,b   Hobbs, Helen H ^a,b   Cohen, Jonathan C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autophagy; Cholesterol; Endosomes; Low density lipoprotein receptor; Lysosomes

Indexed keywords

CLATHRIN HEAVY CHAIN; ESCRT PROTEIN; HEPATOCYTE GROWTH FACTOR REGULATED TYROSINE KINASE SUBSTRATE; KEXIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; PROTEASOME; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SMALL INTERFERING RNA; SUBTILISIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; FETUS; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LYMPHOCYTE; LYSOSOME; MACROAUTOPHAGY; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

CELL LINE; CLATHRIN; ENDOCYTOSIS; FIBROBLASTS; HUMANS; LYSOSOMES; PROPROTEIN CONVERTASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RECEPTORS, LDL; SERINE ENDOPEPTIDASES;

EID: 84864851760     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M028563     Document Type: Article

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