메뉴 건너뛰기




Volumn 80, Issue 7, 2012, Pages 2500-2508

Caenorhabditis elegans immune conditioning with the probiotic bacterium Lactobacillus acidophilus strain ncfm enhances gram-positive immune responses

Author keywords

[No Author keywords available]

Indexed keywords

BAR 1 PROTEIN; BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PMK 1 PROTEIN; PROBIOTIC AGENT; TIR 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84864827343     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.06350-11     Document Type: Article
Times cited : (127)

References (48)
  • 1
    • 0034735919 scopus 로고    scopus 로고
    • Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans
    • Aballay A, Yorgey P, Ausubel FM. 2000. Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans. Curr. Biol. 10, 1539-1542.
    • (2000) Curr. Biol. , vol.10 , pp. 1539-1542
    • Aballay, A.1    Yorgey, P.2    Ausubel, F.M.3
  • 2
    • 17644389315 scopus 로고    scopus 로고
    • Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM
    • Altermann E, et al. 2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Natl. Acad. Sci. U. S. A. 102, 3906-3912.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 3906-3912
    • Altermann, E.1
  • 3
    • 65549102852 scopus 로고    scopus 로고
    • Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity
    • Anyanful A, Easley KA, Benian GM, Kalman D. 2009. Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5, 450-462.
    • (2009) Cell Host Microbe , vol.5 , pp. 450-462
    • Anyanful, A.1    Easley, K.A.2    Benian, G.M.3    Kalman, D.4
  • 4
    • 0037172403 scopus 로고    scopus 로고
    • Genome and virulence determinants of high virulence community-acquired MRSA
    • Baba T, et al. 2002. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359, 1819-1827.
    • (2002) Lancet , vol.359 , pp. 1819-1827
    • Baba, T.1
  • 5
    • 33847285403 scopus 로고    scopus 로고
    • Antifungal chemical compounds identified using a C. elegans pathogenicity assay
    • doi, 10.1371/ journal.ppat.0030018
    • Breger J, et al. 2007. Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog. 3, e18. doi, 10.1371/ journal.ppat.0030018.
    • (2007) PLoS Pathog , vol.3
    • Breger, J.1
  • 6
    • 2442664007 scopus 로고    scopus 로고
    • TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
    • Couillault C, et al. 2004. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat. Immunol. 5, 488-494.
    • (2004) Nat. Immunol. , vol.5 , pp. 488-494
    • Couillault, C.1
  • 7
    • 0025968675 scopus 로고
    • Evaluation of methods for sampling, recovery, and enumeration of bacteria applied to the phylloplane
    • Donegan K, Matyac C, Seidler R, Porteous A. 1991. Evaluation of methods for sampling, recovery, and enumeration of bacteria applied to the phylloplane. Appl. Environ. Microbiol. 57, 51-56.
    • (1991) Appl. Environ. Microbiol. , vol.57 , pp. 51-56
    • Donegan, K.1    Matyac, C.2    Seidler, R.3    Porteous, A.4
  • 8
    • 0035845577 scopus 로고    scopus 로고
    • A simple model host for identifying Grampositive virulence factors
    • Garsin DA, et al. 2001. A simple model host for identifying Grampositive virulence factors. Proc. Natl. Acad. Sci. U. S. A. 98, 10892-10897.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10892-10897
    • Garsin, D.A.1
  • 9
    • 0035179295 scopus 로고    scopus 로고
    • Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
    • Gill HS, Rutherfurd KJ, Cross ML, Gopal PK. 2001. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am. J. Clin. Nutr. 74, 833-839.
    • (2001) Am. J. Clin. Nutr. , vol.74 , pp. 833-839
    • Gill, H.S.1    Rutherfurd, K.J.2    Cross, M.L.3    Gopal, P.K.4
  • 10
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and agerelated disease by DAF-16 and heat-shock factor
    • Hsu A-L, Murphy CT, Kenyon C. 2003. Regulation of aging and agerelated disease by DAF-16 and heat-shock factor. Science 300, 1142-1145.
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.-L.1    Murphy, C.T.2    Kenyon, C.3
  • 11
    • 35448970986 scopus 로고    scopus 로고
    • Influence of lactic acid bacteria on longevity of Caenorhabditis elegans and host defense against Salmonella enterica serovar Enteritidis
    • Ikeda T, Yasui C, Hoshino K, Arikawa K, Nishikawa Y. 2007. Influence of lactic acid bacteria on longevity of Caenorhabditis elegans and host defense against Salmonella enterica serovar Enteritidis. Appl. Environ. Microbiol. 73, 6404-6409.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 6404-6409
    • Ikeda, T.1    Yasui, C.2    Hoshino, K.3    Arikawa, K.4    Nishikawa, Y.5
  • 12
    • 56249116997 scopus 로고    scopus 로고
    • Role for _-catenin and HOXtranscription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions
    • Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. 2008. Role for _-catenin and HOXtranscription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc. Natl. Acad. Sci. U. S. A. 105, 17469-17474.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 17469-17474
    • Irazoqui, J.E.1    Ng, A.2    Xavier, R.J.3    Ausubel, F.M.4
  • 13
    • 77957663969 scopus 로고    scopus 로고
    • Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus
    • doi, 10.1371/journal.ppat.1000982
    • Irazoqui JE, et al. 2010. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 6, e1000982. doi, 10.1371/journal.ppat.1000982.
    • (2010) PLoS Pathog , vol.6
    • Irazoqui, J.E.1
  • 14
    • 72949096858 scopus 로고    scopus 로고
    • Evolution of host innate defence, insights from Caenorhabditis elegans and primitive invertebrates
    • Irazoqui JE, Urbach JM, Ausubel FM. 2010. Evolution of host innate defence, insights from Caenorhabditis elegans and primitive invertebrates. Nat. Rev. Immunol. 10, 47-58.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 47-58
    • Irazoqui, J.E.1    Urbach, J.M.2    Ausubel, F.M.3
  • 15
    • 0037178731 scopus 로고    scopus 로고
    • A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    • Kim DH, et al. 2002. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297, 623-626.
    • (2002) Science , vol.297 , pp. 623-626
    • Kim, D.H.1
  • 16
    • 58249139318 scopus 로고    scopus 로고
    • Released exopolysaccharide (r-EPS) produced from probiotic bacteria reduce biofilm formation of enterohemorrhagic Escherichia coli O157
    • Kim Y, Oh S, Kim SH. 2009. Released exopolysaccharide (r-EPS) produced from probiotic bacteria reduce biofilm formation of enterohemorrhagic Escherichia coli O157, H7. Biochem. Biophys. Res. Commun. 379, 324-329.
    • (2009) H7. Biochem. Biophys. Res. Commun. , vol.379 , pp. 324-329
    • Kim, Y.1    Oh, S.2    Kim, S.H.3
  • 17
    • 77954474565 scopus 로고    scopus 로고
    • Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells
    • Kim Y, Oh S, Yun HS, Kim SH. 2010. Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Lett. Appl. Microbiol. 51, 123-130.
    • (2010) Lett. Appl. Microbiol. , vol.51 , pp. 123-130
    • Kim, Y.1    Oh, S.2    Yun, H.S.3    Kim, S.H.4
  • 18
    • 58049194098 scopus 로고    scopus 로고
    • S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions
    • Konstantinov SR, et al. 2008. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. Proc. Natl. Acad. Sci. U. S. A. 105, 19474-19479.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 19474-19479
    • Konstantinov, S.R.1
  • 19
    • 76949107790 scopus 로고    scopus 로고
    • Host interactions of probiotic bacterial surface molecules, comparison with commensals and pathogens
    • Lebeer S, Vanderleyden J, De Keersmaecker SCJ. 2010. Host interactions of probiotic bacterial surface molecules, comparison with commensals and pathogens. Nat. Rev. Micro. 8, 171-184.
    • (2010) Nat. Rev. Micro. , vol.8 , pp. 171-184
    • Lebeer, S.1    Vanderleyden, J.2    De Keersmaecker, S.C.J.3
  • 20
    • 34347237865 scopus 로고    scopus 로고
    • Indole is an inter-species biofilm signal mediated by SdiA
    • Lee J, Jayaraman A, Wood T. 2007. Indole is an inter-species biofilm signal mediated by SdiA. BMC Microbiol. 7, 42.
    • (2007) BMC Microbiol , vol.7 , pp. 42
    • Lee, J.1    Jayaraman, A.2    Wood, T.3
  • 21
    • 77955718770 scopus 로고    scopus 로고
    • The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis
    • Lee KZ, Kniazeva M, Han M, Pujol N, Ewbank JJ. 2010. The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Virulence 1, 113-122.
    • (2010) Virulence , vol.1 , pp. 113-122
    • Lee, K.Z.1    Kniazeva, M.2    Han, M.3    Pujol, N.4    Ewbank, J.J.5
  • 22
    • 2342475724 scopus 로고    scopus 로고
    • Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
    • Liberati NT, et al. 2004. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc. Natl. Acad. Sci. U. S. A. 101, 6593-6598.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 6593-6598
    • Liberati, N.T.1
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2___CT method
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2___CT method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 0033951452 scopus 로고    scopus 로고
    • Modulating immune responses with probiotic bacteria
    • Matsuzaki T, Chin J. 2000. Modulating immune responses with probiotic bacteria. Immunol. Cell Biol. 78, 67-73.
    • (2000) Immunol. Cell Biol. , vol.78 , pp. 67-73
    • Matsuzaki, T.1    Chin, J.2
  • 25
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449, 819-826.
    • (2007) Nature , vol.449 , pp. 819-826
    • Medzhitov, R.1
  • 27
    • 33745912507 scopus 로고    scopus 로고
    • Identification of novel antimicrobials using a liveanimal infection model
    • Moy TI, et al. 2006. Identification of novel antimicrobials using a liveanimal infection model. Proc. Natl. Acad. Sci. U. S. A. 103, 10414-10419.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 10414-10419
    • Moy, T.I.1
  • 28
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, et al. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1
  • 29
    • 0037470983 scopus 로고    scopus 로고
    • Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    • Paulsen IT, et al. 2003. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science 299, 2071-2074.
    • (2003) Science , vol.299 , pp. 2071-2074
    • Paulsen, I.T.1
  • 30
    • 79954562343 scopus 로고    scopus 로고
    • Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics
    • Plantinga TS, et al. 2011. Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics. Clin. Vaccine Immunol. 18, 621-628.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 621-628
    • Plantinga, T.S.1
  • 31
    • 62449145675 scopus 로고    scopus 로고
    • The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
    • Powell JR, Kim DH, Ausubel FM. 2009. The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response. Proc. Natl. Acad. Sci. U. S. A. 106, 2782-2787.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 2782-2787
    • Powell, J.R.1    Kim, D.H.2    Ausubel, F.M.3
  • 32
    • 0035811018 scopus 로고    scopus 로고
    • A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans
    • Pujol N, et al. 2001. A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Curr. Biol. 11, 809-821.
    • (2001) Curr. Biol. , vol.11 , pp. 809-821
    • Pujol, N.1
  • 33
    • 79959814514 scopus 로고    scopus 로고
    • C. albicans infection of Caenorhabditis elegans induces antifungal immune defenses
    • doi, 10.1371/journal.ppat.1002074
    • Pukkila-Worley R, Ausubel FM, Mylonakis E. 2011. C. albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog. 7, e1002074. doi, 10.1371/journal.ppat.1002074.
    • (2011) PLoS Pathog , vol.7
    • Pukkila-Worley, R.1    Ausubel, F.M.2    Mylonakis, E.3
  • 34
    • 78650291202 scopus 로고    scopus 로고
    • Microbiota restoration, natural and supplemented recovery of human microbial communities
    • Reid G, et al. 2011. Microbiota restoration, natural and supplemented recovery of human microbial communities. Nat. Rev. Microbiol. 9, 27-38.
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 27-38
    • Reid, G.1
  • 35
    • 77952376722 scopus 로고    scopus 로고
    • Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    • doi, 10.1371/journal. pgen.1000892
    • Shivers RP, et al. 2010. Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 6, e1000892. doi, 10.1371/journal. pgen.1000892.
    • (2010) PLoS Genet , vol.6
    • Shivers, R.P.1
  • 36
    • 11844251384 scopus 로고    scopus 로고
    • The worm has turned-microbial virulence modeled in Caenorhabditis elegans
    • Sifri CD, Begun J, Ausubel FM. 2005. The worm has turned-microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol. 13, 119-127.
    • (2005) Trends Microbiol , vol.13 , pp. 119-127
    • Sifri, C.D.1    Begun, J.2    Ausubel, F.M.3
  • 37
    • 79955754401 scopus 로고    scopus 로고
    • Control of lifespan by food bacteria, nutrient limitation and pathogenicity of food in C. elegans
    • So S, Tokumaru T, Miyahara K, Ohshima Y. 2011. Control of lifespan by food bacteria, nutrient limitation and pathogenicity of food in C. elegans. Mech. Ageing Dev. 132, 210-212.
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 210-212
    • So, S.1    Tokumaru, T.2    Miyahara, K.3    Ohshima, Y.4
  • 38
    • 0033582314 scopus 로고    scopus 로고
    • Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis
    • Tan M-W, Mahajan-Miklos S, Ausubel FM. 1999. Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc. Natl. Acad. Sci. U. S. A. 96, 715-720.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 715-720
    • Tan, M.-W.1    Mahajan-Miklos, S.2    Ausubel, F.M.3
  • 39
    • 37849004968 scopus 로고    scopus 로고
    • A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity
    • Tenor JL, Aballay A. 2008. A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep. 9, 103-109.
    • (2008) EMBO Rep , vol.9 , pp. 103-109
    • Tenor, J.L.1    Aballay, A.2
  • 40
    • 77954832198 scopus 로고    scopus 로고
    • Probiotics-host communication, modulation of signaling pathways in the intestine
    • Thomas CM, Versalovic J. 2010. Probiotics-host communication, modulation of signaling pathways in the intestine. Gut Microbes 1, 148-163.
    • (2010) Gut Microbes , vol.1 , pp. 148-163
    • Thomas, C.M.1    Versalovic, J.2
  • 41
    • 33751382748 scopus 로고    scopus 로고
    • p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    • doi, 10.1371/journal.pgen.0020183
    • Troemel ER, et al. 2006. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2, e183. doi, 10.1371/journal.pgen.0020183.
    • (2006) PLoS Genet , vol.2
    • Troemel, E.R.1
  • 42
    • 67651091732 scopus 로고    scopus 로고
    • Patterns of pathogenesis, discrimination of pathogenic and nonpathogenic microbes by the innate immune system
    • Vance RE, Isberg RR, Portnoy DA. 2009. Patterns of pathogenesis, discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 6, 10-21.
    • (2009) Cell Host Microbe , vol.6 , pp. 10-21
    • Vance, R.E.1    Isberg, R.R.2    Portnoy, D.A.3
  • 43
    • 78651301867 scopus 로고    scopus 로고
    • Use of Caenorhabditis elegans for preselecting Lactobacillus isolates to control Salmonella Typhimurium
    • Wang C, et al. 2011. Use of Caenorhabditis elegans for preselecting Lactobacillus isolates to control Salmonella Typhimurium. J. Food Prot. 74, 86-93.
    • (2011) J. Food Prot. , vol.74 , pp. 86-93
    • Wang, C.1
  • 44
    • 77957258287 scopus 로고    scopus 로고
    • Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16
    • Wang X, Wang X, Li L, Wang D. 2010. Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem. Biophys. Res. Commun. 400, 613-618.
    • (2010) Biochem. Biophys. Res. Commun. , vol.400 , pp. 613-618
    • Wang, X.1    Wang, X.2    Li, L.3    Wang, D.4
  • 45
    • 42349105761 scopus 로고    scopus 로고
    • Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
    • Wells JM, Mercenier A. 2008. Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nat. Rev. Microbiol. 6, 349-362.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 349-362
    • Wells, J.M.1    Mercenier, A.2
  • 46
    • 41549093748 scopus 로고    scopus 로고
    • Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection
    • Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank J. 2007. Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol. 8, R194.
    • (2007) Genome Biol , vol.8
    • Wong, D.1    Bazopoulou, D.2    Pujol, N.3    Tavernarakis, N.4    Ewbank, J.5
  • 47
    • 27744466522 scopus 로고    scopus 로고
    • Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans
    • Zhang Y, Lu H, Bargmann CI. 2005. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438, 179-184.
    • (2005) Nature , vol.438 , pp. 179-184
    • Zhang, Y.1    Lu, H.2    Bargmann, C.I.3
  • 48
    • 60749100012 scopus 로고    scopus 로고
    • Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-(β signaling pathway in Caenorhabditis elegans epidermis
    • Zugasti O, Ewbank JJ. 2009. Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-_ signaling pathway in Caenorhabditis elegans epidermis. Nat. Immunol. 10, 249-256.
    • (2009) Nat. Immunol. , vol.10 , pp. 249-256
    • Zugasti, O.1    Ewbank, J.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.