Cholesterol enhances amyloid β deposition in mouse retina by modulating the activities of Aβ-regulating enzymes in retinal pigment epithelial cells

Biochemical and Biophysical Research Communications

Volumn 424, Issue 4, 2012, Pages 704-709

  Wang, Jiying ^a   Ohno Matsui, Kyoko ^a   Morita, Ikuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Secretase; Age related macular degeneration; Amyloid ; Cholesterol; Neprilysin; Retinal pigment epithelium

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; CHOLESTEROL; GAMMA SECRETASE; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA MACULA AGE RELATED DEGENERATION; TRANSMISSION ELECTRON MICROSCOPY;

ADAM PROTEINS; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHOLESTEROL; GENE EXPRESSION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NEPRILYSIN; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER;

MUS; RODENTIA;

EID: 84864823300     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.014     Document Type: Article

References (50)

1. Ferreira S.T., Vieira M.N., De Felice F.G. Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. IUBMB Life 2007, 59:332-345.
2. Saido T.C. Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. Neurobiol. Aging 1998, 19:S69-S75.
3. Iwata N., Tsubuki S., Takaki Y., et al. Metabolic regulation of brain Abeta by neprilysin. Science 2001, 292:1550-1552.
4. Bettegazzi B., Mihailovich M., Di Cesare A., et al. Beta-secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression. Eur. J. Neurosci. 2011, 33:236-243.
5. Vassar R., Bennett B.D., Babu-Khan S., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.
6. Chow V.W., Mattson M.P., Wong P.C., et al. An overview of APP processing enzymes and products. Neuromol. Med. 2010, 12:1-12.
7. Kojro E., Gimpl G., Lammich S., et al. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc. Natl. Acad. Sci. USA 2001, 98:5815-5820.
8. Kurochkin I.V., Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 1994, 345:33-37.
9. Mueller-Steiner S., Zhou Y., Arai H., et al. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 2006, 51:703-714.
10. West S.K. Looking forward to 20/20: a focus on the epidemiology of eye diseases. Epidemiol. Rev. 2000, 22:64-70.
11. Bird A.C., Bressler N.M., Bressler S.B., et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv. Ophthalmol. 1995, 39:367-374.
12. Johnson L.V., Leitner W.P., Rivest A.J., et al. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc. Natl. Acad. Sci. USA 2002, 99:11830-11835.
13. Dentchev T., Milam A.H., Lee V.M., et al. Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol. Vis. 2003, 9:184-190.
14. Yoshida T., Ohno-Matsui K., Ichinose S., et al. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J. Clin. Invest. 2005, 115:2793-2800.
15. Li C.M., Clark M.E., Rudolf M., et al. Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. Exp. Eye Res. 2007, 85:192-201.
16. Rudolf M., Curcio C.A. Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid. J. Histochem. Cytochem. 2009, 57:731-739.
17. Wang L., Clark M.E., Crossman D.K., et al. Abundant lipid and protein components of drusen. PLoS One 2010, 5:e10329.
18. Mares-Perlman J.A., Brady W.E., Klein R., et al. Dietary fat and age-related maculopathy. Arch. Ophthalmol. 1995, 113:743-748.
19. Klein R., Cruickshanks K.J., Nash S.D., et al. The prevalence of age-related macular degeneration and associated risk factors. Arch. Ophthalmol. 2010, 128:750-758.
20. Fitz N.F., Cronican A., Pham T., et al. Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. J. Neurosci. 2010, 30:6862-6872.
21. Levin-Allerhand J.A., Lominska C.E., Smith J.D. Increased amyloid-levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J. Nutr. Health Aging 2002, 6:315-319.
22. Refolo L.M., Malester B., LaFrancois J., et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 2000, 7:321-331.
23. Refolo L.M., Pappolla M.A., LaFrancois J., et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 2001, 8:890-899.
24. Petanceska S.S., DeRosa S., Olm V., et al. Statin therapy for Alzheimer's disease: will it work?. J. Mol. Neurosci. 2002, 19:155-161.
25. Xiong H., Callaghan D., Jones A., et al. Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol. Dis. 2008, 29:422-437.
26. Bodovitz S., Klein W.L. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 1996, 271:4436-4440.
27. Wahrle S., Das P., Nyborg A.C., et al. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis. 2002, 9:11-23.
28. Kugiyama K., Sugiyama S., Matsumura T., et al. Suppression of atherosclerotic changes in cholesterol-fed rabbits treated with an oral inhibitor of neutral endopeptidase 24.11 (EC 3.4.24.11). Arterioscler. Thromb. Vasc. Biol. 1996, 16:1080-1087.
29. Ghribi O., Larsen B., Schrag M., et al. High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp. Neurol. 2006, 200:460-467.
30. Castellano J.M., Kim J., Stewart F.R., et al. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci. Transl. Med. 2011, 3:89ra57.
31. Bales K.R., Liu F., Wu S., et al. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. J. Neurosci. 2009, 29:6771-6779.
32. Miners J.S., Kehoe P., Love S. Neprilysin protects against cerebral amyloid angiopathy and Abeta-induced degeneration of cerebrovascular smooth muscle cells. Brain Pathol. 2011, 21:594-605.
33. Malek G., Johnson L.V., Mace B.E., et al. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. USA 2005, 102:11900-11905.
34. Fahnoe D.C., Knapp J., Johnson G.D., et al. Inhibitor potencies and substrate preference for endothelin-converting enzyme-1 are dramatically affected by pH. J. Cardiovasc. Pharmacol. 2000, 36:S22-S25.
35. Pike L.J. Lipid rafts: bringing order to chaos. J. Lipid Res. 2003, 44:655-667.
36. Williamson R., Usardi A., Hanger D.P., et al. Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J. 2008, 22:1552-1559.
37. Cordy J.M., Hussain I., Dingwall C., et al. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 2003, 100:11735-11740.
38. Wada S., Morishima-Kawashima M., Qi Y., et al. Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry 2003, 42:13977-13986.
39. Angelisova P., Drbal K., Horejsi V., et al. Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase. Blood 1999, 93:1437-1439.
40. Kawarabayashi T., Shoji M., Younkin L.H., et al. Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 2004, 24:3801-3809.
41. Sato K., Tanabe C., Yonemura Y., et al. Localization of mature neprilysin in lipid rafts. J. Neurosci. Res. 2011, 90:870-877.
42. von Tresckow B., Kallen K.J., von Strandmann E.P., et al. Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. J. Immunol. 2004, 172:4324-4331.
43. Frears E.R., Stephens D.J., Walters C.E., et al. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 1999, 10:1699-1705.
44. Shi C., Liu J., Wu F., et al. Beta-sitosterol inhibits high cholesterol-induced platelet beta-amyloid release. J. Bioenerg. Biomembr. 2011, 43:691-697.
45. Simons M., Keller P., De Strooper B., et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA 1998, 95:6460-6464.
46. Dasari B., Prasanthi J.R., Marwarha G., et al. Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. BMC Ophthalmol. 2011, 11:22.
47. Dasari B., Prasanthi J.R., Marwarha G., et al. The oxysterol 27-hydroxycholesterol increases beta-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmol. 2010, 10:22.
48. Dithmar S., Sharara N.A., Curcio C.A., et al. Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane. Arch. Ophthalmol. 2001, 119:1643-1649.
49. Xiu J., Nordberg A., Qi X., et al. Influence of cholesterol and lovastatin on alpha-form of secreted amyloid precursor protein and expression of alpha7 nicotinic receptor on astrocytes. Neurochem. Int. 2006, 49:459-465.
50. Wang J., Ohno-Matsui K., Morita I. Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration. Biochem. Biophys. Res. Commun. 2012, 423:73-78.