Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema: Correlation with variation in apparent diffusion coefficient

Neural Regeneration Research

Volumn 7, Issue 21, 2012, Pages 1659-1666

  Hu, Hui ^a   Lu, Hong ^a   He, Zhanping ^a   Han, Xiangjun ^a   Chen, Jing ^a   Tu, Rong ^b  

^a HAIKOU PEOPLE S HOSPITAL   (China)

^b Medical College of Hainan Province   (China)

Author keywords

Aquaporin 4; Cerebral ischemic edema; Diffusion; Gene silencing; Magnetic resonance imaging; mRNA interference; Neural regeneration

Indexed keywords

AQUAPORIN 4; MESSENGER RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANGIONEUROTIC EDEMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN EDEMA; BRAIN ISCHEMIA; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FEMALE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

EID: 84864818490     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.21.009     Document Type: Article

References (31)

1. Fisher M, Schaebitz W. An overview of acute stroke therapy: past, present, and future. Arch Intern Med. 2000;160(21):3196-3206.
2. Kanekar SG, Zacharia T, Roller R. Imaging of stroke: Part 2, Pathophysiology at the molecular and cellular levels and corresponding imaging changes. AJR Am J Roentgenol. 2012;198(1):63-74.
3. Hofmeijer J, van Putten MJ. Ischemic cerebral damage: an appraisal of synaptic failure. Stroke. 2012;43(2): 607-615.
4. Taniguchi M, Yamashita T, Kumura E, et al. Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat. Brain Res Mol Brain Res. 2000;78(1-2): 131-137.
5. Lu H, Hu H, He ZP. Reperfusion of the rat brain tissues following acute ischemia: the correlation among diffusion-weighted imaging, histopathology, and aquaporin-4 expression. Chin Med J. 2011;124(19): 3148-3153.
6. Gonen KA, Simsek MM. Diffusion weighted imaging and estimation of prognosis using apparent diffusion coefficient measurements in ischemic stroke. Eur J Radiol. 2010;76 (2):157-161.
7. Lu H, Zhang SZ, Hu H, et al. The relationship between MR diffusion imaging and AQP4 expression in ischemia reperfusion rat model. Zhonghua Fangshexue Zazhi. 2009;43(12):1319-1321.
8. Rao KV, Reddy PV, Curtis KM, et al. Aquaporin-4 expression in cultured astrocytes after fluid percussion injury. J Neurotrauma. 2011;28(3):371-381.
9. Gosselin N, Bottari C, Chen JK, et al. Electrophysiology and functional MRI in post-acute mild traumatic brain injury. J Neurotrauma. 2011;28(3):329-341.
10. van Pul C, Buijs J, Janssen MJ, et al. Selecting the best index for following the temporal evolution of apparent diffusion coefficient and diffusion anisotropy after hypoxic-ischemic white matter injury in neonates. AJNR Am J Neuroradiol. 2005;26(3):469-481.
11. Ward P, Counsell S, Allsop J, et al. Reduced fractional anisotropy on diffusion tensor magnetic regoilance imaging after hypoxic-ischemic encephalopathy. Pediatrics. 2008;117(4):el-12.
12. Nakada T. Diffusion tensor analysis: principles and applications. No To Shinkei. 2002;54(4):290-297.
13. Schellinger PD, Bryan RN, Caplan LR, et al. Therapeutics, and of the American Academy of Neurology TAS. Evidence-based guideline: The role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke: report of the therapeutics and technology assessment subcommittee of the American Academy of Neurology. Neurology. 2010;75 (2):177-185.
14. Burdette JH, Ricci PE, Petitti N, et al. Cerebral infarction: time course of signal intensity changes on diffusion-weighted MR images. AJR. 1998;171(3):791-795.
15. Pan J, Konstas AA, Bateman B, et al. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007;49(1): 93-102.
16. Huisman TA, Hawighorst H, Benoit CH, et al. Diffusion weighted MRI: ischemic and traumatic injuries of the central nervous system. Radiology. 2001;41(12): 1038-1047.
17. Badaut J, Lasbennes F, Magistretti PJ, et al. Aquaporins in brain: distribution, physiology, and pathophysiology. J Cereb Blood Flow Metab. 2002;22(4):367-378.
18. Lu H, Zhang SZ, Hu H, et al. The relationship between aquaporin-4 expression and apparent diffusion coefficient on diffusion-weighted imaging ischemia reperfusion brain tissues in rats. Int J Cerebrovasc Dis. 2009;17(3): 166-170.
19. Tourdias T, Dragonu I, Fushimi Y, et al. Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological study. Neuroimage. 2009;47(2):659-666.
20. Chu K, Kang DW, Kim HJ, et al. Diffusion-weighted imaging abnormalities in wernicke encephalopathy: reversible cytotoxic edema? Arch Neurol. 2002;59(1): 123-127.
21. Butcher K, Emery D. Acute stroke imaging. Part II: The ischemic penumbra. Can J Neurol Sci. 2010;37(1):17-27.
22. Sobue K, Asai K, Katsuya H. Aquaporin water channels in the brain and molecular mechanisms of brain edema. Nihon Rinsho. 2006;64(6):1181-1189.
23. Fazzina G, Amorini AM, Marmarou CR, et al. The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat. J Neurotrauma. 2010; 27(2):453-461.
24. Badaut J, Ashwal S, Adami A, et al. Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference. J Cereb Blood Flow Metab. 2011;31(3): 819-831.
25. Yao X, Hrabetová S, Nicholson C, et al. Aquaporin-4-deficient mice have increased extracellular space without tortuosity change. J Neurosci 2008;28:5460-5464.
26. Nicchia GP, Frigeri A, Liuzzi GM, et al. Inhibition of AQP4 expression in astrocytes by RNAi determines alterations in cell morphology, growth, and water transport and induces changes in ischemia related genes. FASEB J. 2003;17:1508-1510.
27. Li YH, Sun SQ. Changes of astrocytes AQP4 protein expression during hypotonic medium in vitro. Zhongguo Jijiu Yixue. 2004;24(2):87-90.
28. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
29. Hu H, Lu H, He ZP. AQP4 expression in hypoxia cultured astrocytes can be inhibited by AQP4 mRNA silence in vitro. Jiepouxue Zazhi. 2011;34(1):73-77.
30. Bao XM, Shu SY, Li SX, et al. The expression of c-fos proto-oncogene albumin in the brain striatum and the limbic system following injection of kainic acid into Meynert basal nucleus in rats. Diyi Junyi Daxue Xuebao. 1999;19(3):193-196.
31. Bitzer M, Klose U, Geist Barth B, et al. Alterations in diffusion and perfusion in the pathogenesis of peritumoral brain edema in meningiomas. Eur Radiol. 2002;12(8): 2062-2076.