Metformin as a treatment for antipsychotic drug side effects: Special focus on women with schizophrenia

American Journal of Psychiatry

Volumn 169, Issue 8, 2012, Pages 774-776

  Smith, Robert C ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; METFORMIN; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; PROLACTIN; RISPERIDONE; SULPIRIDE;

ADJUVANT THERAPY; ADVERSE DRUG REACTION; AMENORRHEA; DRUG MECHANISM; EDITORIAL; ENDOCRINE DISEASE; GASTROINTESTINAL SYMPTOM; GLUCOSE METABOLISM; GONADOTROPIN HORMONE ABNORMALITY; HUMAN; LONG TERM CARE; MENSTRUAL IRREGULARITY; MENSTRUATION DISORDER; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; SCHIZOPHRENIA; SIDE EFFECT; TREATMENT DURATION; WEIGHT GAIN; WEIGHT REDUCTION; WOMEN'S HEALTH;

EID: 84864807644     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2012.12050591     Document Type: Editorial

References (15)

1. Bushe CJ, Bradley AJ, Doshi S, Karagianis J: Changes in weight and metabolic parameters during treatment with antipsychotics and metformin: do the data inform as to potential guideline development? A systematic review of clinical studies. Int J Clin Pract 2009; 63:1743-1761
2. Maayan L, Vakhrusheva J, Correll CU: Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology 2010; 35:1520-1530
3. Newall H, Myles N, Ward PB, Samaras K, Shiers D, Curtis J: Efficacy of metformin for prevention of weight gain in psychiatric populations: a review. Int Clin Psychopharmacol 2012; 27:69-75
4. Wu R-R, Zhao JP, Jin H, Shao P, Fang M-S, Guo X-F, He YQ, Liu YJ, Chen JD, Li LH: Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. JAMA 2008; 299:185-193
5. Carrizo E, Fernández V, Connell L, Sandia I, Prieto D, Mogollón J, Valbuena D, Fernández I, de Baptista EA, Baptista T: Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study. Schizophr Res 2009; 113:19-26
6. Chen C-H, Chiu C-C, Huang M-C, Wu T-H, Liu H-C, Lu M-L: Metformin for metabolic dysregulation in schizophrenic patients treated with olanzapine. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:925-931 (Pubitemid 351609224)
7. Wu RR, Zhao JP, Guo XF, He YQ, Fang MS, Guo WB, Chen JD, Li LH: Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study. Am J Psychiatry 2008; 165:352-358
8. Wu R-R, Jin H, Gao K, Twamley EW, Ou J-J, Shao P, Wang J, Guo X-F, Davis JM, Chan PK, Zhao JP: Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 2012; 169:813-821
9. Malik P, Kemmler G, Hummer M, Riecher-Roessler A, Kahn RS, Fleischhacker WW; EUFEST Study Group: Sexual dysfunction in first-episode schizophrenia patients: results from European First Episode Schizophrenia Trial. J Clin Psychopharmacol 2011; 31:274-280
10. Canuso CM, Goldstein JM, Wojcik J, Dawson R, Brandman D, Klibanski A, Schildkraut JJ, Green AI: Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. Psychiatry Res 2002; 111:11-20 (Pubitemid 34879071)
11. Palomba S, Falbo A, Zullo F, Orio F Jr: Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 2009; 30:1-50
12. Wang D, Chen J, Yu L: Clinical study of metformin in young obese women with amenorrhea. Journal of Jingsu University 2007; 17:498-502
13. Ortega-González C, Cardoza L, Coutiño B, Hidalgo R, Arteaga-Troncoso G, Parra A: Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. J Endocrinol 2005; 184:233-239
14. Manu P, Correll C, van Winkel R, Wampers M, De Hert M: Prediabetes in patients treated with antipsychotic drugs. J Clin Psychiatry 2011; 73:460-466
15. Diabetes Prevention Program Research Group: Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care 2012; 35:731-737