Combined mechanism fouling model and method for optimization of series microfiltration performance

Journal of Membrane Science

Volumn 417-418, Issue , 2012, Pages 144-153

  Giglia, Sal ^a   Straeffer, Greg ^a  

^a EMD Millipore   (United States)

Author keywords

Membrane fouling; Membrane modeling; Microfiltration

Indexed keywords

ADSORPTION MECHANISM; AREA RATIOS; BIOPROCESSES; COMBINED MECHANISMS; CONSTANT FLOW; CONSTANT PRESSURES; FLUID FILTRATION; FOULING MODEL; FOULING RATE; INLET PRESSURES; MEMBRANE FILTERS; MICRO-FILTRATION MEMBRANES; NORMAL FLOW; PREFILTERS; STERILIZING FILTRATION;

ADSORPTION; FLOW RATE; INLET FLOW; MEMBRANE FOULING; OPTIMIZATION;

MICROFILTRATION;

ACCURACY; ARTICLE; BIOFOULING; BIOPROCESS; FLOW RATE; MEMBRANE FILTER; MICROFILTRATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROCESS OPTIMIZATION;

EID: 84864802744     PISSN: 03767388     EISSN: 18733123     Source Type: Journal    
DOI: 10.1016/j.memsci.2012.06.026     Document Type: Article

References (21)

1. Food and Drug Administration (FDA), Guidance for Industry: Sterile Drug products Produced by Aseptic Processing, Current Good Manufacturing Practice, FDA, September 2004.
2. European Commission - Enterprise and Industry Directorate General - Consumer goods - Pharmaceuticals, The Rules Governing Medicinal Products in the European Union, Volume 4, EU Guidelines to Good Manufacturing Practice Medicinal Products for Human and Veterinary Use, Annex 1, Manufacture of Sterile Medicinal Products, 14 February (2008).
3. E. Greb, Can Redundant Filtration Make Sterility Assurance Double Sure?, PharmTech.com, http://pharmtech.findpharma.com/pharmtech/article/articleDetail.jsp?id=740074.
4. Honig E.S., Schwartz P.D. Impact of design and selection of prefilters on operating cost. Filtr. Sep. 1997, 73-78. Jan/Feb.
5. Dixit M., Braeutigam U. The importance of prefiltration. Filtr. Sep. 2007, 24-26. Jul/Aug.
6. max analysis. Desalination 2002, 146:75-81.
7. Velayudhan A., Menon M.K. Modeling of purification operations in biotechnology: enabling process development, optimization, and scale-up. Biotechnol. Prog. 2007, 23:68-73.
8. Rajniak P., Tsinontides S.C., Pham D., Hunke W.A., Reynolds S.D., Chern R.T. Sterilizing filtration-principles and practice for successful scale-up to manufacturing. J. Memb. Sci. 2008, 325:223-237.
9. Hermia J. Constant pressure blocking filtration laws-application to power-law non-Newtonian fluids. Trans. IChemE 1982, 60:183.
10. Grenier A., Meireles M., Aimar P., Carvin P. Analysing flux decline in dead-end filtration. Chem. Eng. Res. Des. 2008, 86(11A):1281-1293.
11. max testing for practical microfiltration train scale-up in biopharmaceutical processing. Pharm. Technol. 1995, 19:64-76.
12. Ho C.C., Zydney A.L. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J. Colloid Interface Sci. 2000, 232:389-399.
13. Duclos-Orsello C., Li W., Ho C.C. A three mechanism model to describe fouling of microfiltration membranes. J. Membr. Sci. 2006, 280:856.
14. Bolton G., LaCasse D., Kuriyel R. Combined models of membrane fouling: development and application to microfiltration and ultrafiltration of biological fluids. J. Membr. Sci. 2006, 277:75-84.
15. Bowen W.R., Calvo J.I., Hernandez A. Steps of membrane blocking in flux decline during protein microfiltration. J. Membr. Sci. 1995, 101:153.
16. Laska M.E., Brooks R.P., Gayton M., Pujar N.S. Robust scale-up of dead-end filtration: impact of filter fouling mechanisms and flow distribution. Biotechnol. Bioeng. 2005, 92:308-320.
17. Bolton G., Boesch A.W., Lazzara M.J. The effects of flow rate on membrane capacity: development and application of adsorptive membrane fouling models. J. Membr. Sci. 2006, 279:625-634.
18. B. Vickroy, D. Quick, A General form of the Gradual Pore Plugging Model and its Application for the Analysis of Membrane Microfiltration, 224th ACS National Meeting, Boston, MA (2002).
19. Ireland T., Bolton G., Noguchi M. Optimizing virus filter performance with prefiltration. BioProcess int. 2005, 3(10):44-47. November.
20. Jornitz M.W., Meltzer T.H. Filtration and Purification in the Biopharmaceutical Industry 2008, Informa Healthcare USA, Inc, New York, 163-192.
21. M. Felo, R. Patil, G. Oulundsen and W. Kools, Implications of capacity dependence on feed pressure for the proper development and scaling of multi-stage filtration processes, 241st ACS National Meeting & Exposition, Anaheim, CA, March, 27-31, 2011.